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Our results revealed that patients were markedly impaired relative to matched control subjects at imagining new experiences. Moreover, we identified a possible source for this deficit. The patients' imagined experiences lacked spatial coherence, consisting instead of fragmented images in the absence of a holistic representation of the environmental setting. The hippocampus, therefore, may make a critical contribution to the creation of new experiences by providing the spatial context into which the disparate elements of an experience can be bound. Given how closely imagined experiences match episodic memories, the absence of this function mediated by the hippocampus, may also fundamentally affect the ability to vividly re-experience the past.<\/jats:p>","DOI":"10.1073\/pnas.0610561104","type":"journal-article","created":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T20:50:34Z","timestamp":1169067034000},"page":"1726-1731","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1141,"title":["Patients with hippocampal amnesia cannot imagine new experiences"],"prefix":"10.1073","volume":"104","author":[{"given":"Demis","family":"Hassabis","sequence":"first","affiliation":[{"name":"*Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharshan","family":"Kumaran","sequence":"additional","affiliation":[{"name":"*Wellcome Trust 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