{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T02:40:47Z","timestamp":1774060847811,"version":"3.50.1"},"reference-count":21,"publisher":"Proceedings of the National Academy of Sciences","issue":"9","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2008,3,4]]},"abstract":"<jats:p>In response to Toll-like receptor ligands, dendritic cells (DCs) dramatically enhance their antigen presentation capacity by stabilizing at the cell-surface MHC II molecules. We demonstrate here that, in human monocyte-derived DCs, the RING-CH ubiquitin E3 ligase, membrane-associated RING-CH I (MARCH I), promotes the ubiquitination of the HLA-DR \u03b2-chain. Thus, in nonactivated DCs, MARCH I induces the surface internalization of mature HLA-DR complexes, therefore reducing their stability and levels. We further demonstrate that the maturation-dependent down-regulation of MARCH I is a key event in MHC class II up-regulation at the surface of LPS-activated DCs. MARCH I is, therefore, a major regulator of HLA-DR traffic, and its loss contributes to the acquisition of the potent immunostimulatory properties of mature human DCs.<\/jats:p>","DOI":"10.1073\/pnas.0708874105","type":"journal-article","created":{"date-parts":[[2008,2,27]],"date-time":"2008-02-27T21:37:26Z","timestamp":1204148246000},"page":"3491-3496","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":212,"title":["MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation"],"prefix":"10.1073","volume":"105","author":[{"given":"Aude","family":"De Gassart","sequence":"first","affiliation":[{"name":"*Centre d'Immunologie de Marseille\u2013Luminy, Universit\u00e9 de la M\u00e9diterran\u00e9e, Case 906, 13288 Marseille Cedex 9, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 631, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6102, 13288 Marseille, France;"}]},{"given":"Voahirana","family":"Camosseto","sequence":"additional","affiliation":[{"name":"*Centre d'Immunologie de Marseille\u2013Luminy, Universit\u00e9 de la M\u00e9diterran\u00e9e, Case 906, 13288 Marseille Cedex 9, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 631, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6102, 13288 Marseille, France;"}]},{"given":"Jacques","family":"Thibodeau","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Microbiologie et Immunologie, Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada H3T 1J4; and"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 743, Montreal, QC, Canada H3T 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