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Here, we show that in response to Lipopolysaccharides (LPS), several microRNAs (miRNAs) are regulated in human monocyte-derived dendritic cells. Among these miRNAs, miR-155 is highly up-regulated during maturation. Using LNA silencing combined to microarray technology, we have identified the Toll-like receptor\/interleukin-1 (TLR\/IL-1) inflammatory pathway as a general target of miR-155. We further demonstrate that miR-155 directly controls the level of TAB2, an important signal transduction molecule. Our observations suggest, therefore, that in mature human DCs, miR-155 is part of a negative feedback loop, which down-modulates inflammatory cytokine production in response to microbial stimuli.<\/jats:p>","DOI":"10.1073\/pnas.0811073106","type":"journal-article","created":{"date-parts":[[2009,2,5]],"date-time":"2009-02-05T02:39:22Z","timestamp":1233801562000},"page":"2735-2740","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":607,"title":["MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells"],"prefix":"10.1073","volume":"106","author":[{"given":"Maurizio","family":"Ceppi","sequence":"first","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Universit\u00e9 de la M\u00e9diterran\u00e9e, Case 906, 13288 Marseille cedex 9, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U631, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6102, 13288 Marseille, France;"}]},{"given":"Patricia M.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Biology and Centre for Environmental and Marine Studies, University of Aveiro, Aveiro, Portugal;"},{"name":"Centro de Investiga\u00e7\u00e3o em Meio Ambiente, Gen\u00e9tica e Oncobiologia, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; 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