{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:52:14Z","timestamp":1777524734369,"version":"3.51.4"},"reference-count":30,"publisher":"Proceedings of the National Academy of Sciences","issue":"20","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2010,5,18]]},"abstract":"<jats:p>The double helix of DNA, when composed of dinucleotide purine-pyrimidine repeats, can adopt a left-handed helical structure called Z-DNA. For reasons not entirely understood, such dinucleotide repeats in genomic sequences have been associated with genomic instability leading to cancer. Adoption of the left-handed conformation results in the formation of conformational junctions: A B-to-Z junction is formed at the boundaries of the helix, whereas a Z-to-Z junction is commonly formed in sequences where the dinucleotide repeat is interrupted by single base insertions or deletions that bring neighboring helices out of phase. B-Z junctions are shown to result in exposed nucleotides vulnerable to chemical or enzymatic modification. Here we describe the three-dimensional structure of a Z-Z junction stabilized by Z\u03b1, the Z-DNA binding domain of the RNA editing enzyme ADAR1. We show that the junction structure consists of a single base pair and leads to partial or full disruption of the helical stacking. The junction region allows intercalating agents to insert themselves into the left-handed helix, which is otherwise resistant to intercalation. However, unlike a B-Z junction, in this structure the bases are not fully extruded, and the stacking between the two left-handed helices is not continuous.<\/jats:p>","DOI":"10.1073\/pnas.1003182107","type":"journal-article","created":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T02:02:58Z","timestamp":1272938578000},"page":"9088-9092","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":43,"title":["Crystal structure of a junction between two Z-DNA helices"],"prefix":"10.1073","volume":"107","author":[{"given":"Matteo","family":"de Rosa","sequence":"first","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande, 6 P-2780-156 Oeiras, Portugal;"},{"name":"Instituto de Tecnologia Qu\u00edmica e Biologica, Universidade Nova de Lisboa, Avenida da Rep\u00fablica Esta\u00e7\u00e3o Agron\u00f3mica Nacional, 2780-157 Oeiras, Portugal;"}]},{"given":"Daniele","family":"de Sanctis","sequence":"additional","affiliation":[{"name":"European Synchrotron Radiation Facility Grenoble, 6 Rue Jules Horowitz, B.P. 220, 38043 Grenoble Cedex 9, France"}]},{"given":"Ana Lucia","family":"Rosario","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biologica, Universidade Nova de Lisboa, Avenida da Rep\u00fablica Esta\u00e7\u00e3o Agron\u00f3mica Nacional, 2780-157 Oeiras, Portugal;"}]},{"given":"Margarida","family":"Archer","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biologica, Universidade Nova de Lisboa, Avenida da Rep\u00fablica Esta\u00e7\u00e3o Agron\u00f3mica Nacional, 2780-157 Oeiras, Portugal;"}]},{"given":"Alexander","family":"Rich","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307; and"}]},{"given":"Alekos","family":"Athanasiadis","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Rua da Quinta Grande, 6 P-2780-156 Oeiras, Portugal;"}]},{"given":"Maria Armenia","family":"Carrondo","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biologica, Universidade Nova de Lisboa, Avenida da Rep\u00fablica Esta\u00e7\u00e3o Agron\u00f3mica Nacional, 2780-157 Oeiras, Portugal;"}]}],"member":"341","published-online":{"date-parts":[[2010,5,3]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/282680a0"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.6.3546"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)33681-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.14.4344"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/294417a0"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.6.1560"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90463-4"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp124"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.16.7550"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0901-761"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408714102"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0431131100"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5421.1841"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1107\/S1744309109002504"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405586101"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810463106"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2007.03.001"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.06.028"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511084103"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04088"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00235a020"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0020391"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi962937b"},{"key":"e_1_3_3_24_2","doi-asserted-by":"crossref","unstructured":"D Kim et al. 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Joint CCP4 + ESF-EAMCB Newsletter on Protein Crystallography No 26 (Daresbury Laboratory Warrington 1992)."},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444994003112"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444902016657"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904019158"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg680"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1003182107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T22:29:19Z","timestamp":1649802559000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1003182107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,3]]},"references-count":30,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2010,5,18]]}},"alternative-id":["10.1073\/pnas.1003182107"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1003182107","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,3]]},"assertion":[{"value":"2010-05-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}