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Here we show that, in\n            <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n            , caloric restriction or inactivation of catalases extends chronological lifespan by inducing elevated levels of the reactive oxygen species hydrogen peroxide, which activate superoxide dismutases that inhibit the accumulation of superoxide anions. Increased hydrogen peroxide in catalase-deficient cells extends chronological lifespan despite parallel increases in oxidative damage. These findings establish a role for hormesis effects of hydrogen peroxide in promoting longevity that have broad implications for understanding aging and age-related diseases.\n          <\/jats:p>","DOI":"10.1073\/pnas.1004432107","type":"journal-article","created":{"date-parts":[[2010,8,10]],"date-time":"2010-08-10T03:08:03Z","timestamp":1281409683000},"page":"15123-15128","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":229,"title":["Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H\n            <sub>2<\/sub>\n            O\n            <sub>2<\/sub>\n            and superoxide dismutase activity"],"prefix":"10.1073","volume":"107","author":[{"given":"Ana","family":"Mesquita","sequence":"first","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o em Ci\u00eancias da Vida e Sa\u00fade (ICVS), Escola de Ci\u00eancias da Sa\u00fade, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal;"}]},{"given":"Martin","family":"Weinberger","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263;"}]},{"given":"Alexandra","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o em Ci\u00eancias da Vida e Sa\u00fade (ICVS), Escola de Ci\u00eancias da Sa\u00fade, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal;"}]},{"given":"Bel\u00e9m","family":"Sampaio-Marques","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o em Ci\u00eancias da Vida e Sa\u00fade (ICVS), Escola de Ci\u00eancias da Sa\u00fade, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal;"}]},{"given":"Bruno","family":"Almeida","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o em Ci\u00eancias da Vida e Sa\u00fade (ICVS), Escola de Ci\u00eancias da Sa\u00fade, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal;"}]},{"given":"Cec\u00edlia","family":"Le\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o em Ci\u00eancias da Vida e Sa\u00fade (ICVS), Escola de Ci\u00eancias da Sa\u00fade, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal;"}]},{"given":"V\u00edtor","family":"Costa","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, 4150-180 Porto, Portugal; 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