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In these mice, synapse number is reduced in an age-dependent manner; reductions are observed at the postpubertal age of 6 wk, but normal at 2 wk of age. Efforts to uncover the biochemical underpinnings of this phenomenon reveal synapse-specific reductions in 14\u20133-3\u03b5 protein and in Disrupted in Schizophrenia-1 (DISC1), two schizophrenia susceptibility factors that have been implicated in the regulation of spine density. Subchronic administration of MK-801, an NMDA receptor antagonist, produces similar synaptic reductions in both spine density and DISC1, indicating that synaptic levels of DISC1 are regulated by NMDA receptor function. The synaptic reduction of DISC1 and 14\u20133-3\u03b5 is developmentally correlated with the age-dependent decrease in striatal spine density.<\/jats:p>","DOI":"10.1073\/pnas.1012621108","type":"journal-article","created":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T05:18:24Z","timestamp":1300771104000},"page":"5795-5800","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":60,"title":["Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner"],"prefix":"10.1073","volume":"108","author":[{"given":"Amy J.","family":"Ramsey","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Toronto, ON, Canada M5S 1A8;"},{"name":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710;"}]},{"given":"Marija","family":"Milenkovic","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Toronto, ON, Canada M5S 1A8;"}]},{"given":"Ana F.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Doctoral Program in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal;"},{"name":"Department of Neurobiology, Duke University Medical Center, Durham, NC 27710;"}]},{"given":"Yasmin","family":"Escobedo-Lozoya","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Duke University Medical Center, Durham, NC 27710;"}]},{"given":"Saurav","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287; and"}]},{"given":"Ali","family":"Salahpour","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Toronto, ON, Canada M5S 1A8;"},{"name":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710;"}]},{"given":"Akira","family":"Sawa","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287; and"}]},{"given":"Ryohei","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Duke University Medical Center, Durham, NC 27710;"},{"name":"Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710"}]},{"given":"Marc G.","family":"Caron","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710;"},{"name":"Department of Neurobiology, Duke University Medical Center, Durham, NC 27710;"}]}],"member":"341","published-online":{"date-parts":[[2011,3,21]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-02-00659.2003"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511244103"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.4.446"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2008.67"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.10.1038"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.05.001"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.27.070203.144336"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2153"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/30748"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0640-10.2010"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704031104"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.06.016"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/72945"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601758103"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.23.1.185"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.03.008"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.01.023"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.02.014"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81972-8"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(09)17906-2"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.01.008"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2009.00504.x"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.30.051606.094222"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2006.03.005"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001237"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn217"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300674"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3826-06.2006"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0136913100"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001880"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3355-09.2009"},{"key":"e_1_3_3_32_2","article-title":"The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function","author":"Wang Q","year":"2010","unstructured":"Q Wang, et al., The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. 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