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In agreement with increased GADD34 levels, an extensive dephosphorylation of the translation initiation factor eIF2\u03b1 was observed during DC activation. Unexpectedly, although DCs display an unusual resistance to protein synthesis inhibition induced in response to cytosolic dsRNA, GADD34 expression did not have a major impact on protein synthesis. GADD34, however, was shown to be required for normal cytokine production both in vitro and in vivo. These observations have important implications in linking further pathogen detection with the integrated stress response pathways.<\/jats:p>","DOI":"10.1073\/pnas.1104491109","type":"journal-article","created":{"date-parts":[[2012,2,7]],"date-time":"2012-02-07T08:14:58Z","timestamp":1328602498000},"page":"3006-3011","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":71,"title":["Protein phosphatase 1 subunit Ppp1r15a\/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells"],"prefix":"10.1073","volume":"109","author":[{"given":"Giovanna","family":"Clavarino","sequence":"first","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University, 13288 Marseille, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U631, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6102, 13288 Marseille, France;"}]},{"given":"Nuno","family":"Cl\u00e1udio","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University, 13288 Marseille, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U631, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6102, 13288 Marseille, France;"}]},{"given":"Alexandre","family":"Dalet","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University, 13288 Marseille, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U631, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6102, 13288 Marseille, France;"}]},{"given":"Seigo","family":"Terawaki","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University, 13288 Marseille, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U631, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6102, 13288 Marseille, France;"}]},{"given":"Th\u00e9r\u00e8se","family":"Couderc","sequence":"additional","affiliation":[{"name":"Microbes and Host Barriers Group, Institut Pasteur, 75015 Paris, France;"},{"name":"INSERM, Equipe avenir U604, 75015 Paris, France; and"}]},{"given":"Lionel","family":"Chasson","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University, 13288 Marseille, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U631, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6102, 13288 Marseille, France;"}]},{"given":"Maurizio","family":"Ceppi","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University, 13288 Marseille, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U631, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6102, 13288 Marseille, France;"}]},{"given":"Enrico K.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University, 13288 Marseille, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U631, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6102, 13288 Marseille, France;"}]},{"given":"Till","family":"Wenger","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University, 13288 Marseille, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U631, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6102, 13288 Marseille, France;"}]},{"given":"Marc","family":"Lecuit","sequence":"additional","affiliation":[{"name":"Microbes and Host Barriers Group, Institut Pasteur, 75015 Paris, France;"},{"name":"INSERM, Equipe avenir U604, 75015 Paris, France; and"},{"name":"Service des Maladies Infectieuses et Tropicales, Universit\u00e9 Paris Descartes, H\u00f4pital Necker-Enfants malades, Assistance Publique-H\u00f4pitaux de Paris, 75015 Paris, France"}]},{"given":"Evelina","family":"Gatti","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University, 13288 Marseille, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U631, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6102, 13288 Marseille, France;"}]},{"given":"Philippe","family":"Pierre","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille-Luminy, Aix-Marseille University, 13288 Marseille, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U631, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 6102, 13288 Marseille, France;"}]}],"member":"341","published-online":{"date-parts":[[2012,2,6]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau J","year":"1998","unstructured":"J Banchereau, RM Steinman, Dendritic cells and the control of immunity. 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