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In contrast, saposin C facilitates CD1 lipid loading in a different way. It uses a stable, membrane-associated topology and was capable of loading lipid antigens without forming soluble saposin\u2013lipid antigen complexes. These findings reveal how saposins use different strategies to facilitate transfer of structurally diverse lipid antigens.<\/jats:p>","DOI":"10.1073\/pnas.1200764109","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T05:11:40Z","timestamp":1329196300000},"page":"4357-4364","update-policy":"http:\/\/dx.doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":43,"title":["Saposins utilize two strategies for lipid transfer and CD1 antigen presentation"],"prefix":"10.1073","volume":"109","author":[{"given":"Luis","family":"Le\u00f3n","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115;"}]},{"given":"Raju V. 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