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IL-17 is preferentially produced by a population of \u03b3\u03b4 T cells, displaying a distinctive CD27\n            <jats:sup>(\u2212)<\/jats:sup>\n            V\u03b36\n            <jats:sup>(+)<\/jats:sup>\n            phenotype, that strongly proliferate in response to tumor challenge. This associates with the mobilization of SPMs that express protumor and proangiogenic molecular mediators upregulated by IL-17. Critically, these SPMs can directly enhance ovarian cancer cell growth. Our work identifies an IL-17\u2013dependent \u03b3\u03b4 T cell\/SPM axis that promotes tumor development and thus counteracts cancer immunosurveillance.\n          <\/jats:p>","DOI":"10.1073\/pnas.1403424111","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T06:59:19Z","timestamp":1407826759000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":192,"title":["Murine CD27\n            <sup>(\u2212)<\/sup>\n            V\u03b36\n            <sup>(+)<\/sup>\n            \u03b3\u03b4 T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages"],"prefix":"10.1073","volume":"111","author":[{"given":"Margarida","family":"Rei","sequence":"first","affiliation":[{"name":"Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London E1 2AT, United Kingdom;"},{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal;"},{"name":"Graduate Program in Areas of Basic and Applied Biology, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal; and"}]},{"given":"Natacha","family":"Gon\u00e7alves-Sousa","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal;"}]},{"given":"Telma","family":"Lan\u00e7a","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal;"}]},{"given":"Richard G.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, United Kingdom"}]},{"given":"Sofia","family":"Mensurado","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de 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