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Our study reveals that the evolutionary-conserved Toll\/NF-\u03baB signaling pathway, which provides the first line of defense against microbial infection, is crucial for wound repair in the embryonic epidermis (the skin) of the insect\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    . Toll\/NF-\u03baB signaling promotes remodeling of cellular junctions and assembly of a cytoskeletal ring around the wound. Contraction of this ring much like a \u201cpurse string\u201d fastens the epidermal gap. The findings set the stage for a similar investigation of the pathway in wound repair in vertebrates.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1408224111","type":"journal-article","created":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T02:01:00Z","timestamp":1417053660000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":66,"title":["The Toll\/NF-\u03baB signaling pathway is required for epidermal wound repair in\n                    <i>Drosophila<\/i>"],"prefix":"10.1073","volume":"111","author":[{"given":"Lara","family":"Carvalho","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular, Edif\u00edcio Egas Moniz, 1649-028 Lisbon, Portugal; and"},{"name":"Centro de Estudos de Doen\u00e7as Cr\u00f3nicas, NOVA Medical School\/Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa, 1169-056 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4193-6089","authenticated-orcid":false,"given":"Ant\u00f3nio","family":"Jacinto","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Edif\u00edcio Egas Moniz, 1649-028 Lisbon, Portugal; 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