{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T11:16:41Z","timestamp":1776856601944,"version":"3.51.2"},"reference-count":44,"publisher":"Proceedings of the National Academy of Sciences","issue":"26","license":[{"start":{"date-parts":[[2016,12,14]],"date-time":"2016-12-14T00:00:00Z","timestamp":1481673600000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/www.pnas.org\/preview_site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/63849\/2009"],"award-info":[{"award-number":["SFRH\/BD\/63849\/2009"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/BIA-BCM\/105610\/2008"],"award-info":[{"award-number":["PTDC\/BIA-BCM\/105610\/2008"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/SAU-MIC\/122082\/2010"],"award-info":[{"award-number":["PTDC\/SAU-MIC\/122082\/2010"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["FP7\/2007-2013"],"award-info":[{"award-number":["FP7\/2007-2013"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chica and Heinz Schaller Foundation","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}]},{"DOI":"10.13039\/501100000781","name":"EC | European Research Council","doi-asserted-by":"publisher","award":["ERC-SG 281719"],"award-info":[{"award-number":["ERC-SG 281719"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,6,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n          <jats:p>\n            The malaria parasite requires the formation of a stage-specific, enigmatic organelle\u2014the crystalloid\u2014for mosquito invasion. Perhaps acting as storage for proteins and lipids, the crystalloid is generated during ookinete formation and dissolved during sporogony in the oocyst. We show here that\n            <jats:italic>Plasmodium berghei<\/jats:italic>\n            expresses an S-acyl-transferase DHHC10 that localizes to the crystalloid. Parasites depleted of\n            <jats:italic>dhhc10<\/jats:italic>\n            produce ookinetes that successfully establish oocysts but fail to produce sporozoites; knockout parasites are characterized by the absence of the crystalloid and the mislocalization of a crystalloid-resident protein.\n          <\/jats:p>","DOI":"10.1073\/pnas.1522381113","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T13:21:07Z","timestamp":1465996867000},"page":"7183-7188","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":35,"title":["Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite"],"prefix":"10.1073","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4940-5207","authenticated-orcid":false,"given":"Jorge M.","family":"Santos","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649-028 Lisbon, Portugal;"}]},{"given":"Neuza","family":"Duarte","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649-028 Lisbon, Portugal;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5084-3485","authenticated-orcid":false,"given":"Jessica","family":"Kehrer","sequence":"additional","affiliation":[{"name":"Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, 69120 Heidelberg, Germany;"}]},{"given":"Jai","family":"Ramesar","sequence":"additional","affiliation":[{"name":"Leiden Malaria Research Group, Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands;"}]},{"given":"M. Cristina","family":"Avramut","sequence":"additional","affiliation":[{"name":"Section on Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands;"}]},{"given":"Abraham J.","family":"Koster","sequence":"additional","affiliation":[{"name":"Section on Electron Microscopy, Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands;"}]},{"given":"Johannes T.","family":"Dessens","sequence":"additional","affiliation":[{"name":"Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene &amp; Tropical Medicine, London WC1E 7HT, United Kingdom"}]},{"given":"Friedrich","family":"Frischknecht","sequence":"additional","affiliation":[{"name":"Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, 69120 Heidelberg, Germany;"}]},{"given":"S\u00e9verine","family":"Chevalley-Maurel","sequence":"additional","affiliation":[{"name":"Leiden Malaria Research Group, Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands;"}]},{"given":"Chris J.","family":"Janse","sequence":"additional","affiliation":[{"name":"Leiden Malaria Research Group, Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands;"}]},{"given":"Blandine","family":"Franke-Fayard","sequence":"additional","affiliation":[{"name":"Leiden Malaria Research Group, Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands;"}]},{"given":"Gunnar R.","family":"Mair","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649-028 Lisbon, Portugal;"},{"name":"Parasitology, Department of Infectious Diseases, University of Heidelberg Medical School, 69120 Heidelberg, Germany;"}]}],"member":"341","published-online":{"date-parts":[[2016,6,14]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12413"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/976827"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2008.08.006"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(69)90145-X"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182011002034"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2010.12.004"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1973.tb06005.x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06254.x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2015.03.002"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030030"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000195"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.06.011"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.15"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2012.08.009"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.06.005"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/483969"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12081"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep16034"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.598094"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0493-0"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1125129"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000767"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn814"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-014-0086-0"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.53"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2013.04.006"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2009.11.008"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000057334"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000853"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00199-4"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(62)90137-2"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2002.03118.x"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2008.09.002"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06407.x"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12187"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103717"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200800404"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200700727"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2084"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08-03-0252"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/gzn039"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.225"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6985745"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.03.027"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1522381113","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1522381113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T05:41:07Z","timestamp":1649828467000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1522381113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,14]]},"references-count":44,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2016,6,28]]}},"alternative-id":["10.1073\/pnas.1522381113"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1522381113","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,14]]},"assertion":[{"value":"2016-06-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}