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The current study demonstrates that absence of the cytoskeletal protein Tau blocks stress-evoked hippocampal synaptic signaling and morphofunctional damages related to both neuronal structure and connectivity as well as subsequent behavioral deficits. These findings suggest, for the first time to our knowledge, that Tau protein is a key regulator of neuronal malfunction found in stress-driven hippocampal pathology.<\/jats:p>","DOI":"10.1073\/pnas.1600953113","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T03:44:38Z","timestamp":1465271078000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":130,"title":["Tau protein is essential for stress-induced brain pathology"],"prefix":"10.1073","volume":"113","author":[{"given":"Sofia","family":"Lopes","sequence":"first","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal;"},{"name":"ICVS\/3B\u2019s-PT Government Associate Laboratory, 4710-057 Braga\/Guimar\u00e3es, Portugal;"}]},{"given":"Jo\u00e3o","family":"Vaz-Silva","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal;"},{"name":"ICVS\/3B\u2019s-PT Government Associate Laboratory, 4710-057 Braga\/Guimar\u00e3es, Portugal;"}]},{"given":"Vitor","family":"Pinto","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057 Braga, Portugal;"},{"name":"ICVS\/3B\u2019s-PT Government Associate Laboratory, 4710-057 Braga\/Guimar\u00e3es, Portugal;"}]},{"given":"Christina","family":"Dalla","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Medical School of Athens, 11527 Goudi, Greece;"}]},{"given":"Nikolaos","family":"Kokras","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Medical School of Athens, 11527 Goudi, Greece;"}]},{"given":"Benedikt","family":"Bedenk","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Psychiatry, 80804 Munich, Germany"}]},{"given":"Natalie","family":"Mack","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Psychiatry, 80804 Munich, Germany"}]},{"given":"Michael","family":"Czisch","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Psychiatry, 80804 Munich, Germany"}]},{"given":"Osborne F. 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