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U.S.A."],"published-print":{"date-parts":[[2016,8,30]]},"abstract":"<jats:title>Significance<\/jats:title>\n          <jats:p>\n            The human ether-\u00e0-go-go\u2013related gene (hERG) potassium channel has an important role in controlling heartbeat. Genetic alterations or drug side effects can reduce the amount of current passing through hERG, prolonging action potential duration and causing irregular heartbeat and sudden death. We uncovered a family of hERG modulators, antibody fragments that bind to a cytoplasmic region [Per-Arnt-Sim (PAS) domain], increasing the magnitude of the repolarizing current I\n            <jats:sub>Kr<\/jats:sub>\n            and reducing duration of the ventricular action potential. 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