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We show that the Ala-to-Val exchange in the gate region of AAT alters its functional dynamics toward neutrophil elastase in the presence of complex lipid-containing plasma and also affects the overall structural flexibility of the protein.\n          <\/jats:p>","DOI":"10.1073\/pnas.1616301114","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T02:00:34Z","timestamp":1488852034000},"page":"3613-3618","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":50,"title":["Common coding variant in\n            <i>SERPINA1<\/i>\n            increases the risk for large artery stroke"],"prefix":"10.1073","volume":"114","author":[{"given":"Rainer","family":"Malik","sequence":"first","affiliation":[{"name":"Institute for Stroke and Dementia Research, Klinikum der Universit\u00e4t M\u00fcnchen, Munich 81377, 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