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In the case of predation, these circuits include \u201creactive fear\u201d circuits involved in fast escape decisions and \u201ccognitive fear\u201d circuits that are involved in more complex processing associated with slow strategic escape. Using neuroimaging combined with computational modeling, we support this differentiation of fear circuits by showing that fast escape decisions are elicited by the periaqueductal gray and midcingulate cortex, regions involved in reactive flight. Conversely, slower escape decisions rely on the hippocampus, posterior cingulate cortex, and prefrontal cortex, a circuit implicated in behavioral flexibility. 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