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U.S.A."],"published-print":{"date-parts":[[2018,5,15]]},"abstract":"<jats:title>Significance<\/jats:title>\n          <jats:p>\n            Our findings demonstrate that metabolic supplementation of mucosal T cells, isolated from patients with active ulcerative colitis (UC), with\n            <jats:italic>N<\/jats:italic>\n            -acetylglucosamine (GlcNAc) leads to the enhancement of branched N-glycosylation on the T cell receptor, which was associated with the control of T cell activation and function. These results were validated in \u201cglycoengineered\u201d mouse models with severe colitis. Overall, our results open new avenues for a targeted-specific therapy in inflammatory bowel disease (IBD). The therapeutic use of GlcNAc (either alone or in combination with other antiinflammatory therapies) represents a simple immunomodulatory strategy in IBD, with absence of side effects, low costs, and the possibility of being used as a simple rescue therapy to avoid unnecessary toxic effects and step-up therapies in IBD.\n          <\/jats:p>","DOI":"10.1073\/pnas.1720409115","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T15:34:50Z","timestamp":1526052890000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":98,"title":["Metabolic control of T cell immune response through glycans in inflammatory bowel disease"],"prefix":"10.1073","volume":"115","author":[{"given":"Ana M.","family":"Dias","sequence":"first","affiliation":[{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal;"},{"name":"Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP), 4200-135 Porto, Portugal;"},{"name":"Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal;"}]},{"given":"Alexandra","family":"Correia","sequence":"additional","affiliation":[{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal;"},{"name":"Institute for Molecular and Cell Biology (IBMC), Immunobiology Group, University of Porto, 4200-135 Porto, Portugal;"}]},{"given":"M\u00e1rcia S.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal;"},{"name":"Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP), 4200-135 Porto, Portugal;"},{"name":"Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal;"}]},{"given":"Catarina R.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal;"},{"name":"Institute of Biomedical Engineering (INEB), 4200-135 Porto, Portugal;"},{"name":"Institute for Biomedicine, Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal;"}]},{"given":"In\u00eas","family":"Alves","sequence":"additional","affiliation":[{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal;"},{"name":"Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP), 4200-135 Porto, Portugal;"}]},{"given":"Vanda","family":"Pinto","sequence":"additional","affiliation":[{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal;"},{"name":"Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP), 4200-135 Porto, Portugal;"}]},{"given":"Telmo A.","family":"Catarino","sequence":"additional","affiliation":[{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal;"},{"name":"Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP), 4200-135 Porto, Portugal;"}]},{"given":"Nuno","family":"Mendes","sequence":"additional","affiliation":[{"name":"Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal;"},{"name":"Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP), 4200-135 Porto, Portugal;"}]},{"given":"Magdalena","family":"Leander","sequence":"additional","affiliation":[{"name":"Hematology Department, Centro Hospitalar do Porto, 4099-001 Porto, Portugal;"},{"name":"Multidisciplinary Unit for Biomedical Research, ICBAS, University of Porto, 4050-313 Porto, Portugal;"}]},{"given":"M. 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