{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T14:58:02Z","timestamp":1774882682192,"version":"3.50.1"},"reference-count":32,"publisher":"Proceedings of the National Academy of Sciences","issue":"23","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2003,11,11]]},"abstract":"<jats:p>Cognitive studies show that both younger and older adults can increase their memory performance after training in using a visuospatial mnemonic, although age-related memory deficits tend to be magnified rather than reduced after training. Little is known about the changes in functional brain activity that accompany training-induced memory enhancement, and whether age-related activity changes are associated with the size of training-related gains. Here, we demonstrate that younger adults show increased activity during memory encoding in occipito-parietal and frontal brain regions after learning the mnemonic. Older adults did not show increased frontal activity, and only those elderly persons who benefited from the mnemonic showed increased occipito-parietal activity. These findings suggest that age-related differences in cognitive reserve capacity may reflect both a frontal processing deficiency and a posterior production deficiency.<\/jats:p>","DOI":"10.1073\/pnas.1735487100","type":"journal-article","created":{"date-parts":[[2003,11,16]],"date-time":"2003-11-16T20:42:47Z","timestamp":1069015367000},"page":"13728-13733","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":203,"title":["Neural correlates of training-related memory improvement in adulthood and aging"],"prefix":"10.1073","volume":"100","author":[{"given":"Lars","family":"Nyberg","sequence":"first","affiliation":[{"name":"Department of Psychology, Ume\u00e5 University, S-901 87 Ume\u00e5, Sweden; Cognitive Neurophysiology Research Group R2-01, Department of Clinical Neuroscience, Karolinska Institutet, S-17176 Stockholm, Sweden; Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, and Stockholm Gerontology Research Center, S-11382 Stockholm, Sweden; and Cognitive Neurology and Memory Research Group, F. C. Donders Centre for Cognitive Neuroimaging, NL-6500 HB Nijmegen, The Netherlands"}]},{"given":"Johan","family":"Sandblom","sequence":"additional","affiliation":[{"name":"Department of Psychology, Ume\u00e5 University, S-901 87 Ume\u00e5, Sweden; Cognitive Neurophysiology Research Group R2-01, Department of Clinical Neuroscience, Karolinska Institutet, S-17176 Stockholm, Sweden; Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, and Stockholm Gerontology Research Center, S-11382 Stockholm, Sweden; and Cognitive Neurology and Memory Research Group, F. C. Donders Centre for Cognitive Neuroimaging, NL-6500 HB Nijmegen, The Netherlands"}]},{"given":"Sari","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Psychology, Ume\u00e5 University, S-901 87 Ume\u00e5, Sweden; Cognitive Neurophysiology Research Group R2-01, Department of Clinical Neuroscience, Karolinska Institutet, S-17176 Stockholm, Sweden; Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, and Stockholm Gerontology Research Center, S-11382 Stockholm, Sweden; and Cognitive Neurology and Memory Research Group, F. C. Donders Centre for Cognitive Neuroimaging, NL-6500 HB Nijmegen, The Netherlands"}]},{"given":"Anna Stigsdotter","family":"Neely","sequence":"additional","affiliation":[{"name":"Department of Psychology, Ume\u00e5 University, S-901 87 Ume\u00e5, Sweden; Cognitive Neurophysiology Research Group R2-01, Department of Clinical Neuroscience, Karolinska Institutet, S-17176 Stockholm, Sweden; Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, and Stockholm Gerontology Research Center, S-11382 Stockholm, Sweden; and Cognitive Neurology and Memory Research Group, F. C. Donders Centre for Cognitive Neuroimaging, NL-6500 HB Nijmegen, The Netherlands"}]},{"given":"Karl Magnus","family":"Petersson","sequence":"additional","affiliation":[{"name":"Department of Psychology, Ume\u00e5 University, S-901 87 Ume\u00e5, Sweden; Cognitive Neurophysiology Research Group R2-01, Department of Clinical Neuroscience, Karolinska Institutet, S-17176 Stockholm, Sweden; Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, and Stockholm Gerontology Research Center, S-11382 Stockholm, Sweden; and Cognitive Neurology and Memory Research Group, F. C. 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