{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:16:55Z","timestamp":1777389415997,"version":"3.51.4"},"reference-count":46,"publisher":"Proceedings of the National Academy of Sciences","issue":"48","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":182,"URL":"https:\/\/www.pnas.org\/site\/aboutpnas\/licenses.xhtml"}],"funder":[{"name":"Fundacao para a Ciencia e a Tecnologia","award":["PTDC\/BIA-EVF\/1624\/2014"],"award-info":[{"award-number":["PTDC\/BIA-EVF\/1624\/2014"]}]},{"name":"Fundacao para a Ciencia e a Tecnologia","award":["IF\/00033\/2014\/CP1256\/CT0005"],"award-info":[{"award-number":["IF\/00033\/2014\/CP1256\/CT0005"]}]},{"name":"Synthesys","award":["SE-TAF-4695"],"award-info":[{"award-number":["SE-TAF-4695"]}]},{"name":"Fundacao para a Ciencia e a Tecnologia","award":["SFRH\/BD\/87126\/2012"],"award-info":[{"award-number":["SFRH\/BD\/87126\/2012"]}]},{"name":"Fundacao para a Ciencia e a Tecnologia","award":["SFRH\/BD\/115089\/2016"],"award-info":[{"award-number":["SFRH\/BD\/115089\/2016"]}]},{"name":"Fundacao para a Ciencia e a Tecnologia","award":["PD\/BD\/108131\/2015"],"award-info":[{"award-number":["PD\/BD\/108131\/2015"]}]},{"name":"Fundacao para a Ciencia e a Tecnologia","award":["PTDC\/BIA-EVL\/28124\/2017"],"award-info":[{"award-number":["PTDC\/BIA-EVL\/28124\/2017"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,11,26]]},"abstract":"<jats:p>\n            Changing from summer-brown to winter-white pelage or plumage is a crucial adaptation to seasonal snow in more than 20 mammal and bird species. Many of these species maintain nonwhite winter morphs, locally adapted to less snowy conditions, which may have evolved independently. Mountain hares (\n            <jats:italic>Lepus timidus<\/jats:italic>\n            ) from Fennoscandia were introduced into the Faroe Islands in 1855. While they were initially winter-white, within \u223c65 y all Faroese hares became winter-gray, a morph that occurs in the source population at low frequency. The documented population history makes this a valuable model for understanding the genetic basis and evolution of the seasonal trait polymorphism. Through whole-genome scans of differentiation and single-nucleotide polymorphism (SNP) genotyping, we associated winter coat color polymorphism to the genomic region of the pigmentation gene\n            <jats:italic>Agouti<\/jats:italic>\n            , previously linked to introgression-driven winter coat color variation in the snowshoe hare (\n            <jats:italic>Lepus americanus<\/jats:italic>\n            ). Lower\n            <jats:italic>Agouti<\/jats:italic>\n            expression in the skin of winter-gray individuals during the autumn molt suggests that regulatory changes may underlie the color polymorphism. Variation in the associated genomic region shows signatures of a selective sweep in the Faroese population, suggesting that positive selection drove the fixation of the variant after the introduction. Whole-genome analyses of several hare species revealed that the winter-gray variant originated through introgression from a noncolor changing species, in keeping with the history of ancient hybridization between the species. Our findings show the recurrent role of introgression in generating winter coat color variation by repeatedly recruiting the regulatory region of\n            <jats:italic>Agouti<\/jats:italic>\n            to modulate seasonal coat color change.\n          <\/jats:p>","DOI":"10.1073\/pnas.1910471116","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T01:25:20Z","timestamp":1573521920000},"page":"24150-24156","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":79,"title":["Introgression drives repeated evolution of winter coat color polymorphism in hares"],"prefix":"10.1073","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8787-1623","authenticated-orcid":false,"given":"Iwona","family":"Giska","sequence":"first","affiliation":[{"name":"CIBIO-InBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos (CIBIO), Rede de Investiga\u00e7\u00e3o em Biodiversidade e Biologia Evolutiva (InBIO), Universidade do Porto, 4485-661 Vair\u00e3o, Portugal;"}]},{"given":"Liliana","family":"Farelo","sequence":"additional","affiliation":[{"name":"CIBIO-InBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos (CIBIO), Rede de Investiga\u00e7\u00e3o em Biodiversidade e Biologia Evolutiva (InBIO), Universidade do Porto, 4485-661 Vair\u00e3o, Portugal;"}]},{"given":"Jo\u00e3o","family":"Pimenta","sequence":"additional","affiliation":[{"name":"CIBIO-InBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos (CIBIO), Rede de Investiga\u00e7\u00e3o em Biodiversidade e Biologia Evolutiva (InBIO), Universidade do Porto, 4485-661 Vair\u00e3o, Portugal;"}]},{"given":"Fernando A.","family":"Seixas","sequence":"additional","affiliation":[{"name":"CIBIO-InBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos (CIBIO), Rede de Investiga\u00e7\u00e3o em Biodiversidade e Biologia Evolutiva (InBIO), Universidade do Porto, 4485-661 Vair\u00e3o, Portugal;"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade of Porto, 4169-007 Porto, Portugal;"},{"name":"Institut des Sciences de l\u2019\u00c9volution, Universit\u00e9 de Montpellier, Centre National de la Recherche Scientifique, Institut de Recherche pour le D\u00e9veloppement, \u00c9cole Pratique des Hautes \u00c9tudes, 34095 Montpellier, France;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0238-3522","authenticated-orcid":false,"given":"Mafalda S.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"CIBIO-InBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos (CIBIO), Rede de Investiga\u00e7\u00e3o em Biodiversidade e Biologia Evolutiva (InBIO), Universidade do Porto, 4485-661 Vair\u00e3o, Portugal;"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade of Porto, 4169-007 Porto, Portugal;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9834-1361","authenticated-orcid":false,"given":"Jo\u00e3o P.","family":"Marques","sequence":"additional","affiliation":[{"name":"CIBIO-InBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos (CIBIO), Rede de Investiga\u00e7\u00e3o em Biodiversidade e Biologia Evolutiva (InBIO), Universidade do Porto, 4485-661 Vair\u00e3o, Portugal;"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade of Porto, 4169-007 Porto, Portugal;"},{"name":"Institut des Sciences de l\u2019\u00c9volution, Universit\u00e9 de Montpellier, Centre National de la Recherche Scientifique, Institut de Recherche pour le D\u00e9veloppement, \u00c9cole Pratique des Hautes \u00c9tudes, 34095 Montpellier, France;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4773-2877","authenticated-orcid":false,"given":"In\u00eas","family":"Miranda","sequence":"additional","affiliation":[{"name":"CIBIO-InBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos (CIBIO), Rede de Investiga\u00e7\u00e3o em Biodiversidade e Biologia Evolutiva (InBIO), Universidade do Porto, 4485-661 Vair\u00e3o, Portugal;"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade of Porto, 4169-007 Porto, Portugal;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4717-3876","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Letty","sequence":"additional","affiliation":[{"name":"Research Department, National Hunting and Wildlife Agency (ONCFS), 34990 Juvignac, France;"}]},{"given":"Hannes","family":"Jenny","sequence":"additional","affiliation":[{"name":"Department of Wildlife and Fishery Service Grison, CH-7001 Chur, Switzerland;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6774-435X","authenticated-orcid":false,"given":"Klaus","family":"Hackl\u00e4nder","sequence":"additional","affiliation":[{"name":"Institute of Wildlife Biology and Game Management, University of Natural Resources and Life Sciences, Vienna, 1180 Vienna, Austria;"}]},{"given":"Ey\u00f0finn","family":"Magnussen","sequence":"additional","affiliation":[{"name":"Faculty of Science and Technology, University of the Faroe Islands, 100 T\u00f3rshavn, Faroe Islands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4473-1908","authenticated-orcid":false,"given":"Jos\u00e9","family":"Melo-Ferreira","sequence":"additional","affiliation":[{"name":"CIBIO-InBIO, Centro de Investiga\u00e7\u00e3o em Biodiversidade e Recursos Gen\u00e9ticos (CIBIO), Rede de Investiga\u00e7\u00e3o em Biodiversidade e Biologia Evolutiva (InBIO), Universidade do Porto, 4485-661 Vair\u00e3o, Portugal;"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade of Porto, 4169-007 Porto, Portugal;"}]}],"member":"341","published-online":{"date-parts":[[2019,11,11]]},"reference":[{"key":"e_1_3_4_1_2","volume-title":"Wonderful Life: The Burgess Shale and the Nature of History","author":"Gould S. J.","year":"1989","unstructured":"S. J. Gould, Wonderful Life: The Burgess Shale and the Nature of History (W. W. Norton & Company, 1989)."},{"key":"e_1_3_4_2_2","volume-title":"Improbable Destinies: How Predictable is Evolution?","author":"Losos J.","year":"2017","unstructured":"J. Losos, Improbable Destinies: How Predictable is Evolution? (Penguin Books, 2017)."},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"eaam5979","DOI":"10.1126\/science.aam5979","article-title":"Contingency and determinism in evolution: Replaying life\u2019s tape","volume":"362","author":"Blount ZD","year":"2018","unstructured":"Blount ZD, Lenski RE, Losos JB (2018) Contingency and determinism in evolution: Replaying life\u2019s tape. Science 362, eaam5979.","journal-title":"Science"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1073\/pnas.1613870114","article-title":"Comparative genomics reveals convergent evolution between the bamboo-eating giant and red pandas","volume":"114","author":"Hu Y.","year":"2017","unstructured":"Y. Hu ., Comparative genomics reveals convergent evolution between the bamboo-eating giant and red pandas. Proc. Natl. Acad. Sci. U.S.A. 114, 1081\u20131086 (2017).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1126\/science.aau7285","article-title":"Parallel adaptation of rabbit populations to myxoma virus","volume":"363","author":"Alves J. M.","year":"2019","unstructured":"J. M. Alves ., Parallel adaptation of rabbit populations to myxoma virus. Science 363, 1319\u20131326 (2019).","journal-title":"Science"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1111\/brv.12405","article-title":"Function and underlying mechanisms of seasonal colour moulting in mammals and birds: What keeps them changing in a warming world?","volume":"93","author":"Zimova M.","year":"2018","unstructured":"M. Zimova ., Function and underlying mechanisms of seasonal colour moulting in mammals and birds: What keeps them changing in a warming world? Biol. Rev. Camb. Philos. Soc. 93, 1478\u20131498 (2018).","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"7360","DOI":"10.1073\/pnas.1222724110","article-title":"Camouflage mismatch in seasonal coat color due to decreased snow duration","volume":"110","author":"Mills L. S.","year":"2013","unstructured":"L. S. Mills ., Camouflage mismatch in seasonal coat color due to decreased snow duration. Proc. Natl. Acad. Sci. U.S.A. 110, 7360\u20137365 (2013).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/ele.12568","article-title":"High fitness costs of climate change-induced camouflage mismatch","volume":"19","author":"Zimova M.","year":"2016","unstructured":"M. Zimova, L. S. Mills, J. J. Nowak, High fitness costs of climate change-induced camouflage mismatch. Ecol. Lett. 19, 299\u2013307 (2016).","journal-title":"Ecol. Lett."},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"7648","DOI":"10.1038\/s41598-018-26057-5","article-title":"Climate change is affecting mortality of weasels due to camouflage mismatch","volume":"8","author":"Atmeh K.","year":"2018","unstructured":"K. Atmeh, A. Andruszkiewicz, K. Zub, Climate change is affecting mortality of weasels due to camouflage mismatch. Sci. Rep. 8, 7648 (2018).","journal-title":"Sci. Rep."},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1126\/science.aan8097","article-title":"Winter color polymorphisms identify global hot spots for evolutionary rescue from climate change","volume":"359","author":"Mills L. S.","year":"2018","unstructured":"L. S. Mills ., Winter color polymorphisms identify global hot spots for evolutionary rescue from climate change. Science 359, 1033\u20131036 (2018).","journal-title":"Science"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.aar5273","article-title":"Adaptive introgression underlies polymorphic seasonal camouflage in snowshoe hares","volume":"360","author":"Jones M. R.","year":"2018","unstructured":"M. R. Jones ., Adaptive introgression underlies polymorphic seasonal camouflage in snowshoe hares. Science 360, 1355\u20131358 (2018).","journal-title":"Science"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.peptides.2004.11.040","article-title":"Two cysteine substitutions in the MC1R generate the blue variant of the Arctic fox (Alopex lagopus) and prevent expression of the white winter coat","volume":"26","author":"V\u00e5ge D. I.","year":"2005","unstructured":"D. I. V\u00e5ge ., Two cysteine substitutions in the MC1R generate the blue variant of the Arctic fox (Alopex lagopus) and prevent expression of the white winter coat. Peptides 26, 1814\u20131817 (2005).","journal-title":"Peptides"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.tig.2010.02.002","article-title":"Vertebrate pigmentation: From underlying genes to adaptive function","volume":"26","author":"Hubbard J. K.","year":"2010","unstructured":"J. K. Hubbard, J. A. Uy, M. E. Hauber, H. E. Hoekstra, R. J. Safran, Vertebrate pigmentation: From underlying genes to adaptive function. Trends Genet. 26, 231\u2013239 (2010).","journal-title":"Trends Genet."},{"key":"e_1_3_4_14_2","first-page":"381","article-title":"On genetics, evolution and history of distribution of the heath-hare: A distinct population of the arctic hare, Lepus timidus Lin","volume":"6","author":"Bergengren A.","year":"1969","unstructured":"A. Bergengren, On genetics, evolution and history of distribution of the heath-hare: A distinct population of the arctic hare, Lepus timidus Lin. Viltrevy (Stockh.) 6, 381\u2013460 (1969).","journal-title":"Viltrevy (Stockh.)"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/3504302","article-title":"Lepus timidus","volume":"495","author":"Angerbj\u00f6rn A.","year":"1995","unstructured":"A. Angerbj\u00f6rn, J. Flux, Lepus timidus. Mamm. Species 495, 1\u201311 (1995).","journal-title":"Mamm. Species"},{"key":"e_1_3_4_16_2","unstructured":"A. Winiger \u201cThe apparent population crash in heath-hares Lepus timidus sylvaticus of southern Sweden\u2013Do complex ecological processes leave detectable fingerprints in long-term hunting bag records?\u201d MSc thesis Swedish University of Agricultural Sciences Ume\u00e5 Sweden (2014)."},{"key":"e_1_3_4_17_2","first-page":"LXV:1","volume-title":"The Zoology of the Faroes","author":"Degerb\u00f8l M.","year":"1940","unstructured":"M. Degerb\u00f8l, \u201cMammalia\u201d in The Zoology of the Faroes, A. S. Jensen, W. Lundbeck, T. Mortensen, R. Sp\u00e4rck, Eds. (A. F. H\u00f8st & S\u00f8n, Copenhagen, 1940) Vol III, pp. LXV:1\u2013133."},{"key":"e_1_3_4_18_2","first-page":"115","volume-title":"Danmarks natur - F\u00e6r\u00f8erne","author":"Reinert A.","year":"1982","unstructured":"A. Reinert, \u201cH\u00f8jere dyr p\u00e5 land\u201d in Danmarks natur - F\u00e6r\u00f8erne, A. N\u00f8rrevang, J. Lund\u00f8, Eds. (Poletikkens Forlag, Copenhagen, 1982), pp. 115\u2013122."},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13059-018-1471-8","article-title":"The genomic impact of historical hybridization with massive mitochondrial DNA introgression","volume":"19","author":"Seixas F. A.","year":"2018","unstructured":"F. A. Seixas, P. Boursot, J. Melo-Ferreira, The genomic impact of historical hybridization with massive mitochondrial DNA introgression. Genome Biol. 19, 91 (2018).","journal-title":"Genome Biol."},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","unstructured":"F. A. Seixas P. Boursot J. Melo-Ferreira Data from \u201cThe genomic impact of historical hybridization with massive mitochondrial DNA introgression.\u201d Dryad. https:\/\/doi.org\/10.5061\/dryad.x95x69pd8. Accessed 30 July 2018.","DOI":"10.1186\/s13059-018-1471-8"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"4428","DOI":"10.3390\/ijms10104428","article-title":"Role of the ubiquitin proteasome system in regulating skin pigmentation","volume":"10","author":"Ando H.","year":"2009","unstructured":"H. Ando, M. Ichihashi, V. J. Hearing, Role of the ubiquitin proteasome system in regulating skin pigmentation. Int. J. Mol. Sci. 10, 4428\u20134434 (2009).","journal-title":"Int. J. Mol. Sci."},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1073\/pnas.0806753106","article-title":"Microarray analysis sheds light on the dedifferentiating role of agouti signal protein in murine melanocytes via the Mc1r","volume":"106","author":"Le Pape E.","year":"2009","unstructured":"E. Le Pape ., Microarray analysis sheds light on the dedifferentiating role of agouti signal protein in murine melanocytes via the Mc1r. Proc. Natl. Acad. Sci. U.S.A. 106, 1802\u20131807 (2009).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1126\/science.1175826","article-title":"On the origin and spread of an adaptive allele in deer mice","volume":"325","author":"Linnen C. R.","year":"2009","unstructured":"C. R. Linnen, E. P. Kingsley, J. D. Jensen, H. E. Hoekstra, On the origin and spread of an adaptive allele in deer mice. Science 325, 1095\u20131098 (2009).","journal-title":"Science"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ygeno.2009.11.003","article-title":"Characterization of the rabbit agouti signaling protein (ASIP) gene: Transcripts and phylogenetic analyses and identification of the causative mutation of the nonagouti black coat colour","volume":"95","author":"Fontanesi L.","year":"2010","unstructured":"L. Fontanesi ., Characterization of the rabbit agouti signaling protein (ASIP) gene: Transcripts and phylogenetic analyses and identification of the causative mutation of the nonagouti black coat colour. Genomics 95, 166\u2013175 (2010).","journal-title":"Genomics"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1111\/mec.14177","article-title":"The transcriptional landscape of seasonal coat colour moult in the snowshoe hare","volume":"26","author":"Ferreira M. S.","year":"2017","unstructured":"M. S. Ferreira ., The transcriptional landscape of seasonal coat colour moult in the snowshoe hare. Mol. Ecol. 26, 4173\u20134185 (2017).","journal-title":"Mol. Ecol."},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.aao6809","article-title":"Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish radiations","volume":"362","author":"Kratochwil C. F.","year":"2018","unstructured":"C. F. Kratochwil ., Agouti-related peptide 2 facilitates convergent evolution of stripe patterns across cichlid fish radiations. Science 362, 457\u2013460 (2018).","journal-title":"Science"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"10701","DOI":"10.1073\/pnas.1708149114","article-title":"Macroevolutionary shifts of WntA function potentiate butterfly wing-pattern diversity","volume":"114","author":"Mazo-Vargas A.","year":"2017","unstructured":"A. Mazo-Vargas ., Macroevolutionary shifts of WntA function potentiate butterfly wing-pattern diversity. Proc. Natl. Acad. Sci. U.S.A. 114, 10701\u201310706 (2017).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nrg2063","article-title":"The evolutionary significance of cis-regulatory mutations","volume":"8","author":"Wray G. A.","year":"2007","unstructured":"G. A. Wray, The evolutionary significance of cis-regulatory mutations. Nat. Rev. Genet. 8, 206\u2013216 (2007).","journal-title":"Nat. Rev. Genet."},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1534\/genetics.110.116459","article-title":"Searching for footprints of positive selection in whole-genome SNP data from nonequilibrium populations","volume":"185","author":"Pavlidis P.","year":"2010","unstructured":"P. Pavlidis, J. D. Jensen, W. Stephan, Searching for footprints of positive selection in whole-genome SNP data from nonequilibrium populations. Genetics 185, 907\u2013922 (2010).","journal-title":"Genetics"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s42003-018-0085-8","article-title":"RAiSD detects positive selection based on multiple signatures of a selective sweep and SNP vectors","volume":"1","author":"Alachiotis N.","year":"2018","unstructured":"N. Alachiotis, P. Pavlidis, RAiSD detects positive selection based on multiple signatures of a selective sweep and SNP vectors. Commun. Biol. 1, 79 (2018).","journal-title":"Commun. Biol."},{"key":"e_1_3_4_31_2","first-page":"240","article-title":"Haren paa F\u00e6r\u00f8erne","volume":"28","author":"Patursson S.","year":"1904","unstructured":"S. Patursson, Haren paa F\u00e6r\u00f8erne. Naturen. 28, 240\u2013241 (1904).","journal-title":"Naturen."},{"key":"e_1_3_4_32_2","unstructured":"F. A. Seixas \u201cGenome admixture with massive mitochondrial DNA introgression in hares ( Lepus spp.): The relative roles of demography and natural selection \u201d PhD thesis University of Porto and University of Montpellier Porto Montpellier (2017)."},{"key":"e_1_3_4_33_2","unstructured":"I. Giska . Lepus timidus WGS. NCBI Sequence Read Archive. https:\/\/www.ncbi.nlm.nih.gov\/bioproject\/PRJNA564335. Deposited 6 September 2019."},{"key":"e_1_3_4_34_2","unstructured":"J. P. Marques . Genomic resources for L. castroviejoi BioSample SAMN12640762. NCBI Sequence Read Archive. https:\/\/www.ncbi.nlm.nih.gov\/biosample\/SAMN12640762. Deposited 27 August 2019."},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","unstructured":"F. A. Seixas P. Boursot J. Melo-Ferreira The genomic impact of historical hybridization with massive mitochondrial DNA introgression in the Iberian hare ( Lepus granatensis ). NCBI Sequence Read Archive. https:\/\/www.ncbi.nlm.nih.gov\/bioproject\/PRJNA399194. Accessed 1 August 2018.","DOI":"10.1186\/s13059-018-1471-8"},{"key":"e_1_3_4_36_2","unstructured":"F. A. Seixas . Genomic resources for L. europaeus BioSample SAMN12618118. NCBI Sequence Read Archive. https:\/\/www.ncbi.nlm.nih.gov\/biosample\/SAMN12618118. Accessed 1 August 2018."},{"key":"e_1_3_4_37_2","unstructured":"F. A. Seixas . Genomic resources for L. europaeus BioSample SAMN12618122. NCBI Sequence Read Archive. https:\/\/www.ncbi.nlm.nih.gov\/biosample\/SAMN12618122. Accessed 1 August 2018."},{"key":"e_1_3_4_38_2","unstructured":"M. R. Jones . Whole exome and whole genome sequencing of hares and jackrabbits (genus Lepus ). NCBI Sequence Read Archive. https:\/\/www.ncbi.nlm.nih.gov\/bioproject\/PRJNA420081. Accessed 1 August 2018."},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/hdy.2013.102","article-title":"Home-loving boreal hare mitochondria survived several invasions in Iberia: The relative roles of recurrent hybridisation and allele surfing","volume":"112","author":"Melo-Ferreira J.","year":"2014","unstructured":"J. Melo-Ferreira ., Home-loving boreal hare mitochondria survived several invasions in Iberia: The relative roles of recurrent hybridisation and allele surfing. Heredity 112, 265\u2013273 (2014).","journal-title":"Heredity"},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1046\/j.1365-294X.1997.t01-1-00199.x","article-title":"The occurrence of mountain hare mitochondrial DNA in wild brown hares","volume":"6","author":"Thulin C. G.","year":"1997","unstructured":"C. G. Thulin, M. Jaarola, H. Tegelstr\u00f6m, The occurrence of mountain hare mitochondrial DNA in wild brown hares. Mol. Ecol. 6, 463\u2013467 (1997).","journal-title":"Mol. Ecol."},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1126\/science.1158997","article-title":"Is genetic evolution predictable?","volume":"323","author":"Stern D. L.","year":"2009","unstructured":"D. L. Stern, V. Orgogozo, Is genetic evolution predictable? Science 323, 746\u2013751 (2009).","journal-title":"Science"},{"key":"e_1_3_4_42_2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/sj.hdy.6800861","article-title":"Genetics, development and evolution of adaptive pigmentation in vertebrates","volume":"97","author":"Hoekstra H. E.","year":"2006","unstructured":"H. E. Hoekstra, Genetics, development and evolution of adaptive pigmentation in vertebrates. Heredity 97, 222\u2013234 (2006).","journal-title":"Heredity"},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1111\/mec.12415","article-title":"Adaptive introgression in animals: Examples and comparison to new mutation and standing variation as sources of adaptive variation","volume":"22","author":"Hedrick P. W.","year":"2013","unstructured":"P. W. Hedrick, Adaptive introgression in animals: Examples and comparison to new mutation and standing variation as sources of adaptive variation. Mol. Ecol. 22, 4606\u20134618 (2013).","journal-title":"Mol. Ecol."},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/molbev\/msx314","article-title":"Disentangling immediate adaptive introgression from selection on standing introgressed variation in humans","volume":"35","author":"Jagoda E.","year":"2017","unstructured":"E. Jagoda ., Disentangling immediate adaptive introgression from selection on standing introgressed variation in humans. Mol. Biol. Evol. 35, 623\u2013630 (2017).","journal-title":"Mol. Biol. Evol."},{"key":"e_1_3_4_45_2","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1126\/science.aav4155","article-title":"Adaptive introgression enables evolutionary rescue from extreme environmental pollution","volume":"364","author":"Oziolor E. M.","year":"2019","unstructured":"E. M. Oziolor ., Adaptive introgression enables evolutionary rescue from extreme environmental pollution. Science 364, 455\u2013457 (2019).","journal-title":"Science"},{"key":"e_1_3_4_46_2","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1111\/mec.12378","article-title":"Introgression and the fate of domesticated genes in a wild mammal population","volume":"22","author":"Feulner P. G. D.","year":"2013","unstructured":"P. G. D. Feulner ., Introgression and the fate of domesticated genes in a wild mammal population. Mol. Ecol. 22, 4210\u20134221 (2013).","journal-title":"Mol. Ecol."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1910471116","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1910471116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T20:40:07Z","timestamp":1654634407000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1910471116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,11]]},"references-count":46,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2019,11,26]]}},"alternative-id":["10.1073\/pnas.1910471116"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1910471116","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,11]]},"assertion":[{"value":"2019-11-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}