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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,6,2]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Sepsis remains a leading cause of death. New insights into its pathophysiology are likely to be key to the development of effective therapeutic strategies against sepsis. Given the role of GDF15 in metabolism regulation and in cachexia during late stages of cancer, features that also occur in sepsis, elucidation of the possible mechanistic role of GDF15 in sepsis is of great importance. We find that septic patients have very high levels of GDF15 in the peripheral blood, which correlate with clinical outcomes. Using\n                    <jats:italic>Gdf15<\/jats:italic>\n                    -deficient mice, we show that GDF15 plays a causal role in sepsis by delaying the local control of infection. These findings suggest GDF15 as a potential therapeutic target in sepsis secondary to a bacterial infection.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1918508117","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T20:29:20Z","timestamp":1589833760000},"page":"12281-12287","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":54,"title":["CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of\n                    <i>Gdf15<\/i>\n                    -deficient mice protects against abdominal sepsis"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8817-2584","authenticated-orcid":false,"given":"Isa","family":"Santos","sequence":"first","affiliation":[{"name":"Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;"},{"name":"Servi\u00e7o de Cirurgia Geral, Hospital de S\u00e3o Bernardo\u2013Centro Hospitalar de Set\u00fabal EPE, 2910-446 Set\u00fabal, Portugal;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2026-0163","authenticated-orcid":false,"given":"Henrique G.","family":"Cola\u00e7o","sequence":"additional","affiliation":[{"name":"Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6506-7829","authenticated-orcid":false,"given":"Ana","family":"Neves-Costa","sequence":"additional","affiliation":[{"name":"Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;"}]},{"given":"Elsa","family":"Seixas","sequence":"additional","affiliation":[{"name":"Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;"}]},{"given":"Tiago R.","family":"Velho","sequence":"additional","affiliation":[{"name":"Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;"}]},{"given":"Dora","family":"Pedroso","sequence":"additional","affiliation":[{"name":"Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;"}]},{"given":"Andr\u00e9","family":"Barros","sequence":"additional","affiliation":[{"name":"Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;"}]},{"given":"Rui","family":"Martins","sequence":"additional","affiliation":[{"name":"Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;"}]},{"given":"Nuno","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Cirurgia Geral, Hospital Garcia de Orta, 2801-951 Almada, Portugal;"},{"name":"Faculdade de Medicina, Universidade de Lisboa, 1649-004 Lisboa, Portugal;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5242-6543","authenticated-orcid":false,"given":"Didier","family":"Payen","sequence":"additional","affiliation":[{"name":"INSERM, UMR 1160, Universite Paris 7 Denis Diderot, Universite-Sorbonne Cit\u00e9, 75013 Paris, France;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3201-2375","authenticated-orcid":false,"given":"Sebastian","family":"Weis","sequence":"additional","affiliation":[{"name":"Institute for Infectious Disease and Infection Control, Jena University Hospital, 07747 Jena, Germany;"},{"name":"Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, 07747 Jena, Germany;"},{"name":"Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3767-1954","authenticated-orcid":false,"given":"Hyon-Seung","family":"Yi","sequence":"additional","affiliation":[{"name":"Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, 35015 Daejeon, Korea;"}]},{"given":"Minho","family":"Shong","sequence":"additional","affiliation":[{"name":"Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, 35015 Daejeon, Korea;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0707-315X","authenticated-orcid":false,"given":"Lu\u00eds F.","family":"Moita","sequence":"additional","affiliation":[{"name":"Innate Immunity and Inflammation Laboratory, Instituto Gulbenkian de Ci\u00eancia, 2780-156 Oeiras, Portugal;"},{"name":"Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina, Universidade de Lisboa, 1649-004 Lisboa, Portugal"}]}],"member":"341","published-online":{"date-parts":[[2020,5,18]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"1","article-title":"Sepsis and septic shock","volume":"6736","author":"Cecconi M.","year":"2018","unstructured":"M. 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