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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2020,7,7]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Malassezia<\/jats:italic>\n                    species are the main fungal components of the mammalian skin microbiome and are associated with a number of skin disorders. Recently,\n                    <jats:italic>Malassezia<\/jats:italic>\n                    has also been found in association with Crohn\u2019s disease and with pancreatic cancer. The elucidation of the molecular bases of skin adaptation by\n                    <jats:italic>Malassezia<\/jats:italic>\n                    is critical to understand its role as commensal and pathogen. In this study we employed evolutionary, molecular, biochemical, and structural analyses to demonstrate that the bacterially derived flavohemoglobins acquired by\n                    <jats:italic>Malassezia<\/jats:italic>\n                    through horizontal gene transfer resulted in a gain of function critical for nitric oxide detoxification and resistance to nitrosative stress. Our study underscores horizontal gene transfer as an important force modulating\n                    <jats:italic>Malassezia<\/jats:italic>\n                    evolution and niche adaptation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2003473117","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T16:45:26Z","timestamp":1592930726000},"page":"15884-15894","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":39,"title":["HGT in the human and skin commensal\n                    <i>Malassezia<\/i>\n                    : A bacterially derived flavohemoglobin is required for NO resistance and host interaction"],"prefix":"10.1073","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3278-8678","authenticated-orcid":false,"given":"Giuseppe","family":"Ianiri","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Duke University Medical Center, 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27705;"}]},{"given":"Ci","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710;"}]},{"given":"Madison","family":"Bolejack","sequence":"additional","affiliation":[{"name":"Union Chimique Belge Pharma, Bainbridge Island, WA 98110;"},{"name":"Seattle Structural Genomics Center for Infectious Disease, Seattle, WA 98101;"}]},{"given":"Olivia","family":"Donovan","sequence":"additional","affiliation":[{"name":"Seattle Structural Genomics Center for Infectious Disease, Seattle, WA 98101;"},{"name":"Union Chimique Belge Pharma, Bedford, MA 01730;"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1077-5515","authenticated-orcid":false,"given":"Hayden","family":"Smutney","sequence":"additional","affiliation":[{"name":"Seattle Structural Genomics Center for Infectious Disease, Seattle, WA 98101;"},{"name":"Union Chimique Belge Pharma, Bedford, MA 01730;"}]},{"given":"Peter","family":"Myler","sequence":"additional","affiliation":[{"name":"Seattle Structural Genomics Center for Infectious Disease, Seattle, WA 98101;"},{"name":"Center for Global Infectious Disease Research, Seattle Children\u2019s Research Institute, Seattle, WA 98101;"},{"name":"Department of Biomedical Information and Medical Education, University of Washington, Seattle, WA 98195;"},{"name":"Department of Global Health, University of Washington, Seattle, WA 98195"}]},{"given":"Fred","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710;"}]},{"suffix":"III","given":"David","family":"Fox","sequence":"additional","affiliation":[{"name":"Union Chimique Belge Pharma, Bainbridge Island, WA 98110;"},{"name":"Seattle Structural Genomics Center for Infectious Disease, Seattle, WA 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