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We reveal the biophysical and structural bases underpinning the potency and specificity of this molecule and demonstrate its ability to redirect polyclonal T cells to target HLA-E-expressing cells transduced with mycobacterial\n            <jats:italic>inhA<\/jats:italic>\n            as well as primary cells infected with virulent Mtb. Additionally, we demonstrate elimination of Mtb-infected cells and reduction of intracellular Mtb growth. Our study suggests an approach to enhance host T cell immunity against Mtb and provides proof of principle for an innovative TCR-based therapeutic strategy overcoming HLA polymorphism and therefore applicable to a broader patient population.\n          <\/jats:p>","DOI":"10.1073\/pnas.2318003121","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T18:00:06Z","timestamp":1714586406000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":12,"title":["An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-5947","authenticated-orcid":false,"given":"Rachel L.","family":"Paterson","sequence":"first","affiliation":[{"name":"Immunocore Ltd., Abingdon, Oxfordshire OX14 4RY, United 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