{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:11:43Z","timestamp":1772806303779,"version":"3.50.1"},"reference-count":59,"publisher":"Elsevier BV","issue":"38","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T00:00:00Z","timestamp":1601769600000},"content-version":"vor","delay-in-days":7338,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1074\/jbc.m002440200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:56:15Z","timestamp":1027695375000},"page":"29628-29635","source":"Crossref","is-referenced-by-count":59,"title":["Ras Oncoprotein Induces CD44 Cleavage through Phosphoinositide 3-OH Kinase and the Rho Family of Small G Proteins"],"prefix":"10.1016","volume":"275","author":[{"given":"Yoshiaki","family":"Kawano","sequence":"first","affiliation":[]},{"given":"Isamu","family":"Okamoto","sequence":"additional","affiliation":[]},{"given":"Daizo","family":"Murakami","sequence":"additional","affiliation":[]},{"given":"Hiroshi","family":"Itoh","sequence":"additional","affiliation":[]},{"given":"Masaki","family":"Yoshida","sequence":"additional","affiliation":[]},{"given":"Shoichi","family":"Ueda","sequence":"additional","affiliation":[]},{"given":"Hideyuki","family":"Saya","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1074\/jbc.M002440200_bib1","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/0092-8674(90)90694-A","volume":"61","author":"Aruffo","year":"1990","journal-title":"Cell"},{"key":"10.1074\/jbc.M002440200_bib2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/0092-8674(89)90639-9","volume":"56","author":"Goldstein","year":"1989","journal-title":"Cell"},{"key":"10.1074\/jbc.M002440200_bib3","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1083\/jcb.118.4.971","volume":"118","author":"Thomas","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M002440200_bib4","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1172\/JCI118970","volume":"98","author":"Svee","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M002440200_bib5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1101\/gad.13.1.35","volume":"13","author":"Yu","year":"1999","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M002440200_bib6","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/(SICI)1097-0215(19990129)80:3<387::AID-IJC9>3.0.CO;2-T","volume":"80","author":"Takahashi","year":"1999","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M002440200_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0092-8674(91)90403-L","volume":"65","author":"Gunthert","year":"1991","journal-title":"Cell"},{"key":"10.1074\/jbc.M002440200_bib8","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/sj.onc.1202447","volume":"18","author":"Okamoto","year":"1999","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M002440200_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0065-230X(08)61023-4","volume":"78","author":"Wells","year":"2000","journal-title":"Adv. Cancer Res."},{"key":"10.1074\/jbc.M002440200_bib10","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/(SICI)1097-0215(19960315)65:6<717::AID-IJC1>3.0.CO;2-1","volume":"65","author":"Heino","year":"1996","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M002440200_bib11","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1083\/jcb.143.5.1375","volume":"143","author":"Gu","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M002440200_bib12","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1002\/j.1460-2075.1995.tb07316.x","volume":"14","author":"Marais","year":"1995","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M002440200_bib13","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/0968-0004(94)90133-3","volume":"19","author":"Daum","year":"1994","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M002440200_bib14","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0092-8674(93)90307-C","volume":"74","author":"Vojtek","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M002440200_bib15","first-page":"7153","volume":"14","author":"Moodie","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M002440200_bib16","doi-asserted-by":"crossref","first-page":"11723","DOI":"10.1074\/jbc.270.20.11723","volume":"270","author":"Yamamori","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002440200_bib17","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/370527a0","volume":"370","author":"Rodriguez-Viciana","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.M002440200_bib18","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1002\/j.1460-2075.1996.tb00602.x","volume":"15","author":"Rodriguez-Viciana","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M002440200_bib19","doi-asserted-by":"crossref","first-page":"12609","DOI":"10.1073\/pnas.91.26.12609","volume":"91","author":"Spaargaren","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M002440200_bib20","first-page":"7483","volume":"14","author":"Kikuchi","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M002440200_bib21","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/j.1460-2075.1996.tb00416.x","volume":"15","author":"Urano","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M002440200_bib22","first-page":"4682","volume":"49","author":"Bos","year":"1989","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M002440200_bib23","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/jnci\/80.7.468","volume":"80","author":"Liotta","year":"1988","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1074\/jbc.M002440200_bib24","first-page":"259","volume":"5","author":"Thorgeirsson","year":"1985","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M002440200_bib25","first-page":"6005","volume":"45","author":"Bondy","year":"1985","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M002440200_bib26","first-page":"3519","volume":"9","author":"Fox","year":"1994","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M002440200_bib27","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1126\/science.3090687","volume":"233","author":"Bar-Sagi","year":"1986","journal-title":"Science"},{"key":"10.1074\/jbc.M002440200_bib28","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/374457a0","volume":"374","author":"Qiu","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M002440200_bib29","doi-asserted-by":"crossref","first-page":"11781","DOI":"10.1073\/pnas.92.25.11781","volume":"92","author":"Qiu","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M002440200_bib30","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1128\/MCB.17.6.3449","volume":"17","author":"Qiu","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M002440200_bib31","first-page":"2289","volume":"10","author":"Prendergast","year":"1995","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M002440200_bib32","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1091\/mbc.8.11.2329","volume":"8","author":"Zhong","year":"1997","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M002440200_bib33","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.279.5350.509","volume":"279","author":"Hall","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M002440200_bib34","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1101\/gad.11.18.2295","volume":"11","author":"Van Aelst","year":"1997","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M002440200_bib35","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0092-8674(92)90163-7","volume":"70","author":"Ridley","year":"1992","journal-title":"Cell"},{"key":"10.1074\/jbc.M002440200_bib36","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0092-8674(92)90164-8","volume":"70","author":"Ridley","year":"1992","journal-title":"Cell"},{"key":"10.1074\/jbc.M002440200_bib37","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1128\/MCB.15.4.1942","volume":"15","author":"Kozma","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M002440200_bib38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0092-8674(95)90370-4","volume":"81","author":"Nobes","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M002440200_bib39","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0092-8674(00)80226-3","volume":"89","author":"Rodriguez-Viciana","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M002440200_bib40","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0960-9822(96)00749-X","volume":"6","author":"Reif","year":"1996","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M002440200_bib41","doi-asserted-by":"crossref","first-page":"25525","DOI":"10.1074\/jbc.274.36.25525","volume":"274","author":"Okamoto","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002440200_bib42","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1101\/gad.9.16.1953","volume":"9","author":"McCarthy","year":"1995","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M002440200_bib43","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0014-5793(98)01457-4","volume":"440","author":"Edamatsu","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M002440200_bib44","doi-asserted-by":"crossref","first-page":"16089","DOI":"10.1074\/jbc.272.26.16089","volume":"272","author":"Kobayashi","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002440200_bib45","doi-asserted-by":"crossref","first-page":"7413","DOI":"10.1073\/pnas.84.21.7413","volume":"84","author":"Felgner","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M002440200_bib46","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1083\/jcb.122.5.1089","volume":"122","author":"Gonzalez","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M002440200_bib47","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1083\/jcb.137.2.481","volume":"137","author":"Klemke","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M002440200_bib48","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/37656","volume":"390","author":"Keely","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.M002440200_bib49","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1128\/MCB.20.1.158-172.2000","volume":"20","author":"Sarner","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M002440200_bib50","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1128\/MCB.19.3.1881","volume":"19","author":"Tang","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M002440200_bib51","doi-asserted-by":"crossref","first-page":"33333","DOI":"10.1074\/jbc.273.50.33333","volume":"273","author":"Manna","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002440200_bib52","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.1093\/emboj\/18.24.6962","volume":"18","author":"Fan","year":"1999","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M002440200_bib53","doi-asserted-by":"crossref","first-page":"28828","DOI":"10.1074\/jbc.274.40.28828","volume":"274","author":"Gechtman","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M002440200_bib54","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1091\/mbc.9.8.2185","volume":"9","author":"Potempa","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M002440200_bib55","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1083\/jcb.143.5.1385","volume":"143","author":"Sander","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M002440200_bib56","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1083\/jcb.147.5.1009","volume":"147","author":"Sander","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M002440200_bib57","first-page":"1516","volume":"53","author":"Hofmann","year":"1993","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.M002440200_bib58","first-page":"417","volume":"9","author":"Jamal","year":"1994","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M002440200_bib59","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/72799","volume":"24","author":"Zuber","year":"2000","journal-title":"Nat. Genet."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819794472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819794472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M002440200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T12:21:02Z","timestamp":1639830062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819794472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":59,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0021925819794472"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m002440200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}