{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:16:11Z","timestamp":1778674571372,"version":"3.51.4"},"reference-count":53,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":7062,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2001,6]]},"DOI":"10.1074\/jbc.m101963200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:09:24Z","timestamp":1027696164000},"page":"19540-19547","source":"Crossref","is-referenced-by-count":27,"title":["G\u03b2\u03b3 Mediate Differentiation of Vascular Smooth Muscle Cells"],"prefix":"10.1016","volume":"276","author":[{"given":"H. Peter","family":"Reusch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Plum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnter","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M101963200_bib1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1146\/annurev.ph.57.030195.004043","volume":"57","author":"Ross","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"10.1074\/jbc.M101963200_bib2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1161\/01.CIR.96.1.82","volume":"96","author":"Aikawa","year":"1997","journal-title":"Circulation"},{"key":"10.1074\/jbc.M101963200_bib3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/01.ATV.18.3.333","volume":"18","author":"Shanahan","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1074\/jbc.M101963200_bib4","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1152\/physrev.1995.75.3.487","volume":"75","author":"Owens","year":"1995","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M101963200_bib5","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1073\/pnas.85.4.1047","volume":"85","author":"Nagai","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M101963200_bib6","doi-asserted-by":"crossref","first-page":"9734","DOI":"10.1016\/S0021-9258(18)81717-3","volume":"264","author":"Nagai","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M101963200_bib7","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1749-6632.1994.tb17365.x","volume":"748","author":"Aikawa","year":"1995","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1074\/jbc.M101963200_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1083\/jcb.107.1.307","volume":"107","author":"Hedin","year":"1988","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M101963200_bib9","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1073\/pnas.85.5.1524","volume":"85","author":"Majesky","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M101963200_bib10","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1083\/jcb.123.3.741","volume":"123","author":"Wilson","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M101963200_bib11","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1161\/01.RES.79.5.1046","volume":"79","author":"Reusch","year":"1996","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M101963200_bib12","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1161\/01.RES.87.3.228","volume":"87","author":"Zeidan","year":"2000","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M101963200_bib13","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0092-8674(00)80351-7","volume":"90","author":"Canagarajah","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M101963200_bib14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1152\/physrev.1999.79.1.143","volume":"79","author":"Widmann","year":"1999","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M101963200_bib15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","volume":"80","author":"Marshall","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M101963200_bib16","doi-asserted-by":"crossref","first-page":"12563","DOI":"10.1074\/jbc.270.21.12563","volume":"270","author":"Linseman","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M101963200_bib17","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/379557a0","volume":"379","author":"Daub","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.M101963200_bib18","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/47260","volume":"402","author":"Prenzel","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M101963200_bib19","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1084\/jem.148.5.1400","volume":"148","author":"Ives","year":"1978","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M101963200_bib20","doi-asserted-by":"crossref","first-page":"6332","DOI":"10.1074\/jbc.272.10.6332","volume":"272","author":"Madsen","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M101963200_bib21","doi-asserted-by":"crossref","first-page":"7631","DOI":"10.1074\/jbc.270.13.7631","volume":"270","author":"Shimizu","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M101963200_bib22","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M101963200_bib23","doi-asserted-by":"crossref","first-page":"27489","DOI":"10.1074\/jbc.270.46.27489","volume":"270","author":"Alessi","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M101963200_bib24","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev.pa.36.040196.002241","volume":"36","author":"Gudermann","year":"1996","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1074\/jbc.M101963200_bib25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1161\/01.RES.87.3.221","volume":"87","author":"Gohla","year":"2000","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M101963200_bib26","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1161\/01.RES.62.4.749","volume":"62","author":"Geisterfer","year":"1988","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M101963200_bib27","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/01.HYP.14.4.413","volume":"14","author":"Geisterfer","year":"1989","journal-title":"Hypertension"},{"key":"10.1074\/jbc.M101963200_bib28","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1161\/01.RES.68.1.288","volume":"68","author":"Turla","year":"1991","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M101963200_bib29","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1161\/01.RES.75.6.1126","volume":"75","author":"van Putten","year":"1994","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M101963200_bib30","doi-asserted-by":"crossref","first-page":"29842","DOI":"10.1074\/jbc.272.47.29842","volume":"272","author":"Madsen","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M101963200_bib31","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0092-8674(93)90237-K","volume":"73","author":"Marais","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M101963200_bib32","doi-asserted-by":"crossref","first-page":"22537","DOI":"10.1074\/jbc.M003000200","volume":"275","author":"Garat","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M101963200_bib33","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1074\/jbc.M005505200","volume":"276","author":"Mack","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M101963200_bib34","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1096\/fasebj.9.9.7601337","volume":"9","author":"Seger","year":"1995","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M101963200_bib35","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0092-8674(95)90403-4","volume":"80","author":"Hill","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M101963200_bib36","doi-asserted-by":"crossref","first-page":"23366","DOI":"10.1074\/jbc.272.37.23366","volume":"272","author":"Racke","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M101963200_bib37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0092-8674(00)80096-3","volume":"86","author":"Crompton","year":"1996","journal-title":"Cell"},{"key":"10.1074\/jbc.M101963200_bib38","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/bj2880351","volume":"288","author":"Traverse","year":"1992","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M101963200_bib39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/364249a0","volume":"364","author":"Kolch","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.M101963200_bib40","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1126\/science.280.5360.109","volume":"280","author":"Marais","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M101963200_bib41","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/376737a0","volume":"376","author":"Lev","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M101963200_bib42","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1074\/jbc.272.7.4637","volume":"272","author":"Luttrell","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M101963200_bib43","doi-asserted-by":"crossref","first-page":"20989","DOI":"10.1074\/jbc.274.30.20989","volume":"274","author":"Zwick","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M101963200_bib44","doi-asserted-by":"crossref","first-page":"12251","DOI":"10.1074\/jbc.275.16.12251","volume":"275","author":"Grosse","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M101963200_bib45","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/383547a0","volume":"383","author":"Dikic","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.M101963200_bib46","doi-asserted-by":"crossref","first-page":"19125","DOI":"10.1074\/jbc.272.31.19125","volume":"272","author":"Della Rocca","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M101963200_bib47","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1126\/science.7694366","volume":"262","author":"Wu","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.M101963200_bib48","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1126\/science.7694367","volume":"262","author":"Cook","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.M101963200_bib49","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1124\/mol.58.3.608","volume":"58","author":"Piiper","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M101963200_bib50","doi-asserted-by":"crossref","first-page":"9572","DOI":"10.1074\/jbc.275.13.9572","volume":"275","author":"Maudsley","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M101963200_bib51","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1126\/science.283.5402.655","volume":"283","author":"Luttrell","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.M101963200_bib53","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/382268a0","volume":"382","author":"Mattingly","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.M101963200_bib52","doi-asserted-by":"crossref","first-page":"14251","DOI":"10.1074\/jbc.270.24.14251","volume":"270","author":"Pumiglia","year":"1995","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819670985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819670985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M101963200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T11:36:24Z","timestamp":1639827384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819670985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":53,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["S0021925819670985"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m101963200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2001,6]]}}}