{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T17:43:37Z","timestamp":1776534217873,"version":"3.51.2"},"reference-count":54,"publisher":"Elsevier BV","issue":"49","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":6879,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2001,12]]},"DOI":"10.1074\/jbc.m108378200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:02:28Z","timestamp":1027695748000},"page":"46046-46053","source":"Crossref","is-referenced-by-count":297,"title":["Critical Role of cAMP-GEFII\u00b7Rim2 Complex in Incretin-potentiated Insulin Secretion"],"prefix":"10.1016","volume":"276","author":[{"given":"Yasushige","family":"Kashima","sequence":"first","affiliation":[]},{"given":"Takashi","family":"Miki","sequence":"additional","affiliation":[]},{"given":"Tadao","family":"Shibasaki","sequence":"additional","affiliation":[]},{"given":"Nobuaki","family":"Ozaki","sequence":"additional","affiliation":[]},{"given":"Masaru","family":"Miyazaki","sequence":"additional","affiliation":[]},{"given":"Hideki","family":"Yano","sequence":"additional","affiliation":[]},{"given":"Susumu","family":"Seino","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1074\/jbc.M108378200_bib1","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1152\/physrev.1981.61.4.914","volume":"61","author":"Wollheim","year":"1981","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M108378200_bib2","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1152\/physrev.1987.67.4.1185","volume":"67","author":"Prentki","year":"1987","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M108378200_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0303-7207(90)90152-X","volume":"70","author":"Zawalich","year":"1990","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1074\/jbc.M108378200_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.50.1.1","volume":"50","author":"Schuit","year":"2001","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M108378200_bib5","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1172\/JCI105663","volume":"46","author":"Malaisse","year":"1967","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M108378200_bib6","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0021-9258(17)37941-3","volume":"254","author":"Katada","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M108378200_bib7","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1210\/endo-117-3-824","volume":"117","author":"Pipeleers","year":"1985","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M108378200_bib8","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1210\/endo-117-3-834","volume":"117","author":"Schuit","year":"1985","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M108378200_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1042\/bj1220115","volume":"122","author":"Montague","year":"1971","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M108378200_bib10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1042\/bj1290551","volume":"129","author":"Montague","year":"1972","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M108378200_bib11","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1210\/jcem-24-10-1076","volume":"24","author":"Elrick","year":"1964","journal-title":"J. Clin. Endocrinol."},{"key":"10.1074\/jbc.M108378200_bib12","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1172\/JCI105685","volume":"46","author":"Perley","year":"1967","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M108378200_bib13","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1210\/edrv-16-3-390","volume":"16","author":"Fehmann","year":"1995","journal-title":"Endocr. Rev."},{"key":"10.1074\/jbc.M108378200_bib14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2337\/diab.47.2.159","volume":"47","author":"Drucker","year":"1998","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M108378200_bib15","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1210\/edrv.20.6.0385","volume":"20","author":"Kieffer","year":"1999","journal-title":"Endocr. Rev."},{"key":"10.1074\/jbc.M108378200_bib16","first-page":"487","volume":"31","author":"Brown","year":"1975","journal-title":"Prog. Horm. Res."},{"key":"10.1074\/jbc.M108378200_bib17","doi-asserted-by":"crossref","first-page":"8641","DOI":"10.1073\/pnas.89.18.8641","volume":"89","author":"Thorens","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M108378200_bib18","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1210\/endo.133.6.8243312","volume":"133","author":"Usdin","year":"1993","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M108378200_bib19","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1006\/bbrc.1994.2844","volume":"205","author":"Yasuda","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M108378200_bib20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2337\/diab.45.2.257","volume":"45","author":"Moens","year":"1996","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M108378200_bib21","first-page":"429","volume":"19","author":"Jones","year":"1998","journal-title":"Endocr. Rev."},{"key":"10.1074\/jbc.M108378200_bib22","first-page":"276","volume":"4","author":"Wollheim","year":"1996","journal-title":"Diabetes Rev."},{"key":"10.1074\/jbc.M108378200_bib23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1210\/endo.133.1.8391428","volume":"133","author":"Wheeler","year":"1993","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M108378200_bib24","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1210\/endo.140.9.6947","volume":"140","author":"Bode","year":"1999","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M108378200_bib25","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.2337\/diabetes.49.7.1156","volume":"49","author":"Skoglund","year":"2000","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M108378200_bib26","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/35041046","volume":"2","author":"Ozaki","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M108378200_bib27","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1073\/pnas.96.2.760","volume":"96","author":"Takahashi","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M108378200_bib28","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1074\/jbc.271.14.8075","volume":"271","author":"Thorens","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M108378200_bib29","doi-asserted-by":"crossref","first-page":"4722","DOI":"10.1093\/emboj\/18.17.4722","volume":"18","author":"B\u00e9guin","year":"1999","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M108378200_bib30","doi-asserted-by":"crossref","first-page":"11945","DOI":"10.1073\/pnas.93.21.11945","volume":"93","author":"Hirling","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M108378200_bib31","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0304-3940(95)11317-P","volume":"186","author":"Oho","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1074\/jbc.M108378200_bib32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1469-7793.1997.105bl.x","volume":"502","author":"Renstr\u00f6m","year":"1997","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M108378200_bib33","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1126\/science.282.5397.2275","volume":"282","author":"Kawasaki","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M108378200_bib34","doi-asserted-by":"crossref","first-page":"20829","DOI":"10.1074\/jbc.M001113200","volume":"275","author":"de Rooij","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M108378200_bib35","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/35073073","volume":"2","author":"Bos","year":"2001","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1074\/jbc.M108378200_bib36","doi-asserted-by":"crossref","first-page":"10402","DOI":"10.1073\/pnas.95.18.10402","volume":"95","author":"Miki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M108378200_bib37","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.2337\/diabetes.48.10.2001","volume":"48","author":"Kawaki","year":"1999","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M108378200_bib38","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1172\/JCI112855","volume":"79","author":"Mojsov","year":"1987","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M108378200_bib39","doi-asserted-by":"crossref","first-page":"782","DOI":"10.2337\/diab.27.7.782","volume":"27","author":"Brown","year":"1978","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M108378200_bib41","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1016\/S0021-9258(19)34116-X","volume":"265","author":"Chijiwa","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M108378200_bib42","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1002\/j.1460-2075.1995.tb00033.x","volume":"14","author":"Lang","year":"1995","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M108378200_bib43","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1056\/NEJM196905152802008","volume":"280","author":"Steiner","year":"1969","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M108378200_bib44","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1073\/pnas.84.10.3434","volume":"84","author":"Drucker","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M108378200_bib45","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1038\/nm1196-1254","volume":"2","author":"Scrocchi","year":"1996","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M108378200_bib46","doi-asserted-by":"crossref","first-page":"14843","DOI":"10.1073\/pnas.96.26.14843","volume":"96","author":"Miyawaki","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M108378200_bib47","series-title":"Molecular Basis of Pancreas Development and Function","first-page":"109","author":"Holz","year":"2001"},{"key":"10.1074\/jbc.M108378200_bib48","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s004240050558","volume":"435","author":"Gromada","year":"1998","journal-title":"Pfl\u00fcgers Arch."},{"key":"10.1074\/jbc.M108378200_bib49","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2337\/diab.46.4.615","volume":"46","author":"Ding","year":"1997","journal-title":"Diabetes"},{"key":"10.1074\/jbc.M108378200_bib50","doi-asserted-by":"crossref","first-page":"12441","DOI":"10.1073\/pnas.92.26.12441","volume":"92","author":"Kleppisch","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M108378200_bib51","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/bj2540211","volume":"254","author":"Garcia","year":"1988","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M108378200_bib52","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1042\/bj1800219","volume":"180","author":"Sugden","year":"1979","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M108378200_bib53","doi-asserted-by":"crossref","first-page":"14942","DOI":"10.1073\/pnas.94.26.14942","volume":"94","author":"Lester","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M108378200_bib54","doi-asserted-by":"crossref","first-page":"6297","DOI":"10.1074\/jbc.272.10.6297","volume":"272","author":"Gray","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M108378200_bib40","first-page":"209","volume":"99","author":"Lippe","year":"1991","journal-title":"Comp. Biochem. Physiol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819374022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819374022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M108378200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T05:24:23Z","timestamp":1618205063000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819374022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":54,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["S0021925819374022"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m108378200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}