{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:41:15Z","timestamp":1772894475115,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T00:00:00Z","timestamp":1601769600000},"content-version":"vor","delay-in-days":6851,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1074\/jbc.m109049200","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:03:26Z","timestamp":1027695806000},"page":"2804-2811","source":"Crossref","is-referenced-by-count":101,"title":["Ca2+\/Calmodulin-dependent Protein Kinase II Is Required for Microcystin-induced Apoptosis"],"prefix":"10.1016","volume":"277","author":[{"given":"Kari E.","family":"Fladmark","sequence":"first","affiliation":[]},{"given":"Odd T.","family":"Brustugun","sequence":"additional","affiliation":[]},{"given":"Gunnar","family":"Mellgren","sequence":"additional","affiliation":[]},{"given":"Camilla","family":"Krakstad","sequence":"additional","affiliation":[]},{"given":"Roald","family":"B\u00f8e","sequence":"additional","affiliation":[]},{"given":"Olav K.","family":"Vintermyr","sequence":"additional","affiliation":[]},{"given":"Howard","family":"Schulman","sequence":"additional","affiliation":[]},{"given":"Stein O.","family":"D\u00f8skeland","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1074\/jbc.M109049200_bib1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/0959-440X(93)90159-I","volume":"3","author":"Holmes","year":"1993","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1074\/jbc.M109049200_bib2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/376745a0","volume":"376","author":"Goldberg","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M109049200_bib3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0014-4827(91)90523-W","volume":"195","author":"B\u00f8e","year":"1991","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.M109049200_bib4","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1242\/jcs.107.12.3363","volume":"107","author":"Gjertsen","year":"1994","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M109049200_bib5","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/excr.2001.5223","volume":"266","author":"Li","year":"2001","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.M109049200_bib6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1601-0825.1999.tb00073.x","volume":"5","author":"Morimoto","year":"1999","journal-title":"Oral Dis."},{"key":"10.1074\/jbc.M109049200_bib7","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ijc.2910530225","volume":"53","author":"Chambers","year":"1993","journal-title":"Int. J. Cancer"},{"key":"10.1074\/jbc.M109049200_bib8","doi-asserted-by":"crossref","first-page":"12332","DOI":"10.1016\/S0021-9258(17)32720-5","volume":"269","author":"Zheng","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109049200_bib9","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/sj.cdd.4400873","volume":"8","author":"Sandal","year":"2001","journal-title":"Cell Death Differ."},{"key":"10.1074\/jbc.M109049200_bib10","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/sj.cdd.4400590","volume":"6","author":"Fladmark","year":"1999","journal-title":"Cell Death Differ."},{"key":"10.1074\/jbc.M109049200_bib11","first-page":"395","volume":"4","author":"Kikuchi","year":"1999","journal-title":"Int. J. Mol. Med."},{"key":"10.1074\/jbc.M109049200_bib12","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0006-2952(97)00539-X","volume":"55","author":"Kawamura","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.M109049200_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF00211401","volume":"24","author":"Spassova","year":"1995","journal-title":"Eur. Biophys. J."},{"key":"10.1074\/jbc.M109049200_bib14","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1146\/annurev.pharmtox.41.1.471","volume":"41","author":"Hook","year":"2001","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1074\/jbc.M109049200_bib15","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1093\/oxfordjournals.jbchem.a002915","volume":"129","author":"Ishida","year":"2001","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1074\/jbc.M109049200_bib16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1096\/fj.00-0106com","volume":"15","author":"See","year":"2001","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M109049200_bib17","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.ph.57.030195.002221","volume":"57","author":"Braun","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"10.1074\/jbc.M109049200_bib18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1146\/annurev.bi.61.070192.003015","volume":"61","author":"Hanson","year":"1992","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M109049200_bib19","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1074\/jbc.R000013200","volume":"276","author":"Soderling","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109049200_bib20","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1096\/fasebj.11.11.9285482","volume":"11","author":"Wright","year":"1997","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M109049200_bib21","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1021\/bi00565a023","volume":"19","author":"Blumenthal","year":"1980","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M109049200_bib22","first-page":"466","volume":"8","author":"Takebe","year":"1988","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M109049200_bib23","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/0896-6273(94)90306-9","volume":"12","author":"Hanson","year":"1994","journal-title":"Neuron"},{"key":"10.1074\/jbc.M109049200_bib24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1113\/jphysiol.1995.sp020944","volume":"488","author":"Braun","year":"1995","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.M109049200_bib25","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/jcp.1041630203","volume":"163","author":"Mellgren","year":"1995","journal-title":"J. Cell. Physiol."},{"key":"10.1074\/jbc.M109049200_bib26","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/0076-6879(83)01033-2","volume":"101","author":"Graessmann","year":"1983","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M109049200_bib27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/jcp.1041560122","volume":"156","author":"Vintermyr","year":"1993","journal-title":"J. Cell. Physiol."},{"key":"10.1074\/jbc.M109049200_bib28","doi-asserted-by":"crossref","first-page":"20599","DOI":"10.1074\/jbc.270.35.20599","volume":"270","author":"Gjertsen","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109049200_bib29","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1083\/jcb.126.4.839","volume":"126","author":"Srinivasan","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M109049200_bib30","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0003-9861(90)90348-3","volume":"280","author":"Foster","year":"1990","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.M109049200_bib31","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1006\/bbrc.1995.2040","volume":"212","author":"Ishida","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M109049200_bib32","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-5793(98)00405-0","volume":"427","author":"Ishida","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M109049200_bib33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1432-1033.1992.tb16913.x","volume":"206","author":"D\u00f8skeland","year":"1992","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M109049200_bib34","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1210\/endo.138.10.5426","volume":"138","author":"Mellgren","year":"1997","journal-title":"Endocrinology"},{"key":"10.1074\/jbc.M109049200_bib35","first-page":"10154","volume":"262","author":"Connelly","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M109049200_bib36","doi-asserted-by":"crossref","first-page":"28424","DOI":"10.1074\/jbc.273.43.28424","volume":"273","author":"Rich","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109049200_bib37","doi-asserted-by":"crossref","first-page":"41620","DOI":"10.1074\/jbc.M103674200","volume":"276","author":"Saelens","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109049200_bib38","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1128\/MCB.20.2.684-696.2000","volume":"20","author":"Sabourin","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M109049200_bib39","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0968-0004(93)90109-Z","volume":"18","author":"Hubbard","year":"1993","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.M109049200_bib40","doi-asserted-by":"crossref","first-page":"24396","DOI":"10.1074\/jbc.273.38.24396","volume":"273","author":"Damer","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109049200_bib41","doi-asserted-by":"crossref","first-page":"8975","DOI":"10.1016\/S0021-9258(19)38796-4","volume":"265","author":"Ikebe","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M109049200_bib42","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1083\/jcb.140.3.627","volume":"140","author":"Mills","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M109049200_bib43","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/emboj\/16.5.998","volume":"16","author":"Cohen","year":"1997","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M109049200_bib44","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1038\/sj.onc.1202701","volume":"18","author":"Kawai","year":"1999","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M109049200_bib45","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/35070009","volume":"3","author":"Coleman","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M109049200_bib46","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/35070019","volume":"3","author":"Sebbagh","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M109049200_bib47","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1021\/bi00439a010","volume":"28","author":"Kwiatkowski","year":"1989","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M109049200_bib48","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0065-2571(99)00030-8","volume":"40","author":"Krebs","year":"2000","journal-title":"Adv. Enzyme Regul."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820877357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820877357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M109049200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T23:08:24Z","timestamp":1641424104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820877357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S0021925820877357"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m109049200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}