{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T17:00:26Z","timestamp":1774026026280,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"37","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":2937,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1074\/jbc.m111.304238","type":"journal-article","created":{"date-parts":[[2012,7,18]],"date-time":"2012-07-18T22:20:31Z","timestamp":1342650031000},"page":"31527-31539","source":"Crossref","is-referenced-by-count":37,"title":["The Stalk Domain and the Glycosylation Status of the Activating Natural Killer Cell Receptor NKp30 Are Important for Ligand Binding"],"prefix":"10.1016","volume":"287","author":[{"given":"Jessica","family":"Hartmann","sequence":"first","affiliation":[]},{"given":"Thuy-Van","family":"Tran","sequence":"additional","affiliation":[]},{"given":"Janina","family":"Kaudeer","sequence":"additional","affiliation":[]},{"given":"Karin","family":"Oberle","sequence":"additional","affiliation":[]},{"given":"Julia","family":"Herrmann","sequence":"additional","affiliation":[]},{"given":"Isabell","family":"Quagliano","sequence":"additional","affiliation":[]},{"given":"Tobias","family":"Abel","sequence":"additional","affiliation":[]},{"given":"Andr\u00e9","family":"Cohnen","sequence":"additional","affiliation":[]},{"given":"Volker","family":"Gatterdam","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Jacobs","sequence":"additional","affiliation":[]},{"given":"Bernd","family":"Wollscheid","sequence":"additional","affiliation":[]},{"given":"Robert","family":"Tamp\u00e9","sequence":"additional","affiliation":[]},{"given":"Carsten","family":"Watzl","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Diefenbach","sequence":"additional","affiliation":[]},{"given":"Joachim","family":"Koch","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1074\/jbc.M111.304238_bib1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib2","first-page":"67","article-title":"Natural killer cells in HIV-1 infection: a double-edged sword","volume":"13","author":"Funke","year":"2011","journal-title":"AIDS Rev."},{"key":"10.1074\/jbc.M111.304238_bib3","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1159\/000327014","article-title":"Mechanisms of tumor and viral immune escape from natural killer cell-mediated surveillance","volume":"3","author":"Groth","year":"2011","journal-title":"J. Innate Immun."},{"key":"10.1074\/jbc.M111.304238_bib4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/sj.cdd.4402170","article-title":"NK cells at the interface between innate and adaptive immunity","volume":"15","author":"Moretta","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1074\/jbc.M111.304238_bib5","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1159\/000323923","article-title":"The bidirectional crosstalk between human dendritic cells and natural killer cells","volume":"3","author":"Wehner","year":"2011","journal-title":"J. Innate Immun."},{"key":"10.1074\/jbc.M111.304238_bib6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.19.1.197","article-title":"Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis","volume":"19","author":"Moretta","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im1410s84","article-title":"Human natural killer receptors, co-receptors, and their ligands","author":"Biassoni","year":"2009","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib8","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1182\/blood.V99.10.3661","article-title":"Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia","volume":"99","author":"Costello","year":"2002","journal-title":"Blood"},{"key":"10.1074\/jbc.M111.304238_bib9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.leukres.2005.06.020","article-title":"Expression of natural cytotoxicity receptors NKp30, NKp44, and NKp46 mRNAs and proteins by human hematopoietic and non-hematopoietic cells","volume":"30","author":"Srivastava","year":"2006","journal-title":"Leuk. Res."},{"key":"10.1074\/jbc.M111.304238_bib10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0165-5728(00)00221-6","article-title":"Involvement of natural cytotoxicity receptors in human natural killer cell-mediated lysis of neuroblastoma and glioblastoma cell lines","volume":"107","author":"Sivori","year":"2000","journal-title":"J. Neuroimmunol."},{"key":"10.1074\/jbc.M111.304238_bib11","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1002\/(SICI)1521-4141(199905)29:05<1656::AID-IMMU1656>3.0.CO;2-1","article-title":"NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against autologous, allogeneic or xenogeneic target cells","volume":"29","author":"Sivori","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib12","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1084\/jem.190.10.1505","article-title":"Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells","volume":"190","author":"Pende","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M111.304238_bib13","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1084\/jem.188.5.953","article-title":"Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity","volume":"188","author":"Pessino","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M111.304238_bib14","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1084\/jem.186.7.1129","article-title":"p46, a novel natural killer cell-specific surface molecule that mediates cell activation","volume":"186","author":"Sivori","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M111.304238_bib15","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1084\/jem.187.12.2065","article-title":"NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis","volume":"187","author":"Vitale","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M111.304238_bib16","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ni1190","article-title":"Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus","volume":"6","author":"Arnon","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib17","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.immuni.2007.10.010","article-title":"Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells","volume":"27","author":"Pogge von Strandmann","year":"2007","journal-title":"Immunity"},{"key":"10.1074\/jbc.M111.304238_bib18","doi-asserted-by":"crossref","first-page":"e3377","DOI":"10.1371\/journal.pone.0003377","article-title":"Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function","volume":"3","author":"Simhadri","year":"2008","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M111.304238_bib19","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1084\/jem.20090681","article-title":"The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans","volume":"206","author":"Brandt","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M111.304238_bib20","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1182\/blood-2004-10-4035","article-title":"NK-dependent DC maturation is mediated by TNF\u03b1 and IFN\u03b3 released upon engagement of the NKp30 triggering receptor","volume":"106","author":"Vitale","year":"2005","journal-title":"Blood"},{"key":"10.1074\/jbc.M111.304238_bib21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1084\/jem.20011149","article-title":"Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells","volume":"195","author":"Ferlazzo","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M111.304238_bib22","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.4049\/jimmunol.173.4.2392","article-title":"Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46","volume":"173","author":"Bloushtain","year":"2004","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4049\/jimmunol.175.1.207","article-title":"Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan","volume":"175","author":"Warren","year":"2005","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib24","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1002\/1521-4141(200109)31:9<2680::AID-IMMU2680>3.0.CO;2-A","article-title":"Recognition of viral hemagglutinins by NKp44 but not by NKp30","volume":"31","author":"Arnon","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib25","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/35059110","article-title":"Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells","volume":"409","author":"Mandelboim","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.304238_bib26","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.4049\/jimmunol.178.5.2688","article-title":"NKp46 and NKG2D recognition of infected dendritic cells is necessary for NK cell activation in the human response to influenza infection","volume":"178","author":"Draghi","year":"2007","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib27","doi-asserted-by":"crossref","first-page":"e1002195","DOI":"10.1371\/journal.ppat.1002195","article-title":"Modulation of NKp30- and NKp46-mediated natural killer cell responses by poxviral hemagglutinin","volume":"7","author":"Jarahian","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1074\/jbc.M111.304238_bib28","doi-asserted-by":"crossref","first-page":"5693","DOI":"10.4049\/jimmunol.1102267","article-title":"Proliferating cell nuclear antigen is a novel inhibitory ligand for the natural cytotoxicity receptor NKp44","volume":"187","author":"Rosental","year":"2011","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib29","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1073\/pnas.1100622108","article-title":"Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site","volume":"108","author":"Joyce","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.304238_bib30","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1084\/jem.20102548","article-title":"Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6","volume":"208","author":"Li","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M111.304238_bib31","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/eji.1830111015","article-title":"Surface antigens of human melanoma cells defined by monoclonal antibodies. I. Biochemical characterization of two antigens found on cell lines and fresh tumors of diverse tissue origin","volume":"11","author":"Johnson","year":"1981","journal-title":"Eur. J. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib32","doi-asserted-by":"crossref","first-page":"49125","DOI":"10.1074\/jbc.M109396200","article-title":"A response calculus for immobilized T cell receptor ligands","volume":"276","author":"Andersen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M111.304238_bib33","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/nmeth.1514","article-title":"Specific gene transfer to neurons, endothelial cells and hematopoietic progenitors with lentiviral vectors","volume":"7","author":"Anliker","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1074\/jbc.M111.304238_bib34","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/mt.2008.6","article-title":"A multicolor panel of novel lentiviral \u201cgene ontology\u201d (LeGO) vectors for functional gene analysis","volume":"16","author":"Weber","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1074\/jbc.M111.304238_bib35","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1101\/gad.4.10.1823","article-title":"Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor","volume":"4","author":"Fiering","year":"1990","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M111.304238_bib36","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.1073\/pnas.96.10.5640","article-title":"Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity","volume":"96","author":"Mandelboim","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1074\/jbc.M111.304238_bib37","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/332563a0","article-title":"Localization of the binding site for the human high-affinity Fc receptor on IgG","volume":"332","author":"Duncan","year":"1988","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.304238_bib38","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/j.jaci.2009.09.046","article-title":"Structure and function of immunoglobulins","volume":"125","author":"Schroeder","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib39","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.4049\/jimmunol.163.7.4041","article-title":"IL-2 receptor-targeted cytolytic IL-2\/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice","volume":"163","author":"Zheng","year":"1999","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib40","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/332738a0","article-title":"The binding site for C1q on IgG","volume":"332","author":"Duncan","year":"1988","journal-title":"Nature"},{"key":"10.1074\/jbc.M111.304238_bib41","doi-asserted-by":"crossref","first-page":"e1339","DOI":"10.1371\/journal.pone.0001339","article-title":"Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44","volume":"2","author":"Byrd","year":"2007","journal-title":"PLoS One"},{"key":"10.1074\/jbc.M111.304238_bib42","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1084\/jem.156.6.1794","article-title":"Isolation of the receptor for IgG from a human monocyte cell line (U937) and from human peripheral blood monocytes","volume":"156","author":"Anderson","year":"1982","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M111.304238_bib43","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.4049\/jimmunol.135.3.1975","article-title":"Structural requirements of immunoglobulin G for binding to the Fc gamma receptors of the human tumor cell lines U937, HL-60, ML-1, and K562","volume":"135","author":"McCool","year":"1985","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib44","first-page":"166","article-title":"TMbase - A database of membrane spanning protein segments","volume":"374","author":"Hofmann","year":"1993","journal-title":"Biol. Chem. Hoppe-Seyler"},{"key":"10.1074\/jbc.M111.304238_bib45","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1034\/j.1600-065X.2002.18915.x","article-title":"Imaging immune surveillance by T cells and NK cells","volume":"189","author":"McCann","year":"2002","journal-title":"Immunol. Rev."},{"key":"10.1074\/jbc.M111.304238_bib46","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nri2381","article-title":"Formation and function of the lytic NK-cell immunological synapse","volume":"8","author":"Orange","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib47","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ni1043","article-title":"Cis association of Ly49A with MHC class I restricts natural killer cell inhibition","volume":"5","author":"Doucey","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1074\/jbc.M111.304238_bib48","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nm.2366","article-title":"Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors","volume":"17","author":"Delahaye","year":"2011","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M111.304238_bib49","doi-asserted-by":"crossref","first-page":"8108","DOI":"10.1128\/JVI.00211-09","article-title":"Activation of natural killer cells by newcastle disease virus hemagglutinin-neuraminidase","volume":"83","author":"Jarahian","year":"2009","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M111.304238_bib50","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1182\/blood-2003-05-1716","article-title":"The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46","volume":"103","author":"Arnon","year":"2004","journal-title":"Blood"},{"key":"10.1074\/jbc.M111.304238_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10409239709085144","article-title":"Glycosylation: heterogeneity and the 3D structure of proteins","volume":"32","author":"Rudd","year":"1997","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1074\/jbc.M111.304238_bib52","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/glycob\/cwm125","article-title":"Altered glycosylation of recombinant NKp30 hampers binding to heparan sulfate: a lesson for the use of recombinant immunoreceptors as an immunological tool","volume":"18","author":"Hershkovitz","year":"2008","journal-title":"Glycobiology"},{"key":"10.1074\/jbc.M111.304238_bib53","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/eji.200636429","article-title":"Identification and hormonal regulation of a novel form of NKp30 in human endometrial epithelium","volume":"38","author":"Ponnampalam","year":"2008","journal-title":"Eur. J. Immunol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820631003?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820631003?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M111.304238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T06:21:43Z","timestamp":1714198903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820631003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":53,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0021925820631003"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m111.304238","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}