{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T19:55:29Z","timestamp":1776455729833,"version":"3.51.2"},"reference-count":50,"publisher":"Elsevier BV","issue":"35","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":6658,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2002,8]]},"DOI":"10.1074\/jbc.m204016200","type":"journal-article","created":{"date-parts":[[2002,8,26]],"date-time":"2002-08-26T14:39:46Z","timestamp":1030372786000},"page":"31893-31899","source":"Crossref","is-referenced-by-count":34,"title":["Elimination of Cholesterol Ester from Macrophage Foam Cells by Adenovirus-mediated Gene Transfer of Hormone-sensitive Lipase"],"prefix":"10.1016","volume":"277","author":[{"given":"Hiroaki","family":"Okazaki","sequence":"first","affiliation":[]},{"given":"Jun-ichi","family":"Osuga","sequence":"additional","affiliation":[]},{"given":"Kazuhisa","family":"Tsukamoto","sequence":"additional","affiliation":[]},{"given":"Naoyuki","family":"Isoo","sequence":"additional","affiliation":[]},{"given":"Tetsuya","family":"Kitamine","sequence":"additional","affiliation":[]},{"given":"Yoshiaki","family":"Tamura","sequence":"additional","affiliation":[]},{"given":"Sachiko","family":"Tomita","sequence":"additional","affiliation":[]},{"given":"Motohiro","family":"Sekiya","sequence":"additional","affiliation":[]},{"given":"Naoya","family":"Yahagi","sequence":"additional","affiliation":[]},{"given":"Yoko","family":"Iizuka","sequence":"additional","affiliation":[]},{"given":"Ken","family":"Ohashi","sequence":"additional","affiliation":[]},{"given":"Kenji","family":"Harada","sequence":"additional","affiliation":[]},{"given":"Takanari","family":"Gotoda","sequence":"additional","affiliation":[]},{"given":"Hitoshi","family":"Shimano","sequence":"additional","affiliation":[]},{"given":"Satoshi","family":"Kimura","sequence":"additional","affiliation":[]},{"given":"Ryozo","family":"Nagai","sequence":"additional","affiliation":[]},{"given":"Nobuhiro","family":"Yamada","sequence":"additional","affiliation":[]},{"given":"Shun","family":"Ishibashi","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1074\/jbc.M204016200_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M204016200_bib2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/01.CIR.104.3.365","volume":"104","author":"Libby","year":"2001","journal-title":"Circulation"},{"key":"10.1074\/jbc.M204016200_bib3","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1172\/JCI9919","volume":"105","author":"de Winther","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M204016200_bib4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.bi.52.070183.001255","volume":"52","author":"Brown","year":"1983","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M204016200_bib5","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1146\/annurev.biochem.66.1.613","volume":"66","author":"Chang","year":"1997","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M204016200_bib6","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1172\/JCI8119","volume":"104","author":"Lawn","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M204016200_bib7","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0022-2275(20)30266-2","volume":"42","author":"Santamarina-Fojo","year":"2001","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M204016200_bib8","doi-asserted-by":"crossref","first-page":"9344","DOI":"10.1016\/S0021-9258(19)70568-7","volume":"255","author":"Brown","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204016200_bib9","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S1388-1981(00)00144-X","volume":"1529","author":"Buhman","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M204016200_bib10","doi-asserted-by":"crossref","first-page":"21324","DOI":"10.1074\/jbc.M002541200","volume":"275","author":"Yagyu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204016200_bib11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1172\/JCI10310","volume":"107","author":"Fazio","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M204016200_bib12","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1074\/jbc.270.11.5772","volume":"270","author":"Warner","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204016200_bib13","doi-asserted-by":"crossref","first-page":"22773","DOI":"10.1074\/jbc.271.37.22773","volume":"271","author":"Tabas","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204016200_bib14","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0014-5793(89)81335-3","volume":"247","author":"Small","year":"1989","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M204016200_bib15","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/S0022-2275(20)35114-2","volume":"34","author":"Khoo","year":"1993","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M204016200_bib16","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1161\/01.ATV.17.12.3428","volume":"17","author":"Reue","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1074\/jbc.M204016200_bib17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.nutr.20.1.365","volume":"20","author":"Holm","year":"2000","journal-title":"Annu. Rev. Nutr."},{"key":"10.1074\/jbc.M204016200_bib18","doi-asserted-by":"crossref","first-page":"12659","DOI":"10.1016\/S0021-9258(18)42944-4","volume":"256","author":"Khoo","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204016200_bib19","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0021-9258(17)35229-8","volume":"266","author":"Bernard","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204016200_bib20","doi-asserted-by":"crossref","first-page":"34508","DOI":"10.1074\/jbc.M006738200","volume":"275","author":"Oram","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204016200_bib21","doi-asserted-by":"crossref","first-page":"7987","DOI":"10.1073\/pnas.97.14.7987","volume":"97","author":"Santamarina-Fojo","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M204016200_bib22","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1073\/pnas.97.2.787","volume":"97","author":"Osuga","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M204016200_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physiolgenomics.2000.2.1.1","volume":"2","author":"Ghosh","year":"2000","journal-title":"Physiol. Genomics"},{"key":"10.1074\/jbc.M204016200_bib24","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1161\/01.ATV.18.6.991","volume":"18","author":"Escary","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1074\/jbc.M204016200_bib25","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0022-2275(20)32443-3","volume":"40","author":"Escary","year":"1999","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M204016200_bib26","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1074\/jbc.271.7.3639","volume":"271","author":"Ye","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204016200_bib27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1172\/JCI119501","volume":"100","author":"Tsukamoto","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M204016200_bib28","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI103182","volume":"34","author":"Havel","year":"1955","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M204016200_bib29","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1073\/pnas.76.1.333","volume":"76","author":"Goldstein","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M204016200_bib30","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0076-6879(83)98152-1","volume":"98","author":"Goldstein","year":"1983","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M204016200_bib31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1042\/bj2260319","volume":"226","author":"Roberts","year":"1985","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M204016200_bib32","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0022-2275(20)39990-9","volume":"34","author":"Kraemer","year":"1993","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M204016200_bib33","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0022-2275(20)40725-4","volume":"19","author":"Heider","year":"1978","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M204016200_bib34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0021-9150(00)00457-3","volume":"154","author":"Perrey","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1074\/jbc.M204016200_bib35","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0014-5793(99)01521-5","volume":"462","author":"Wang","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M204016200_bib36","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/S0022-2275(20)32363-4","volume":"41","author":"Fu","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M204016200_bib37","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0021-9150(95)05695-5","volume":"120","author":"Graham","year":"1996","journal-title":"Atherosclerosis"},{"key":"10.1074\/jbc.M204016200_bib38","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1161\/01.ATV.18.10.1589","volume":"18","author":"Kritharides","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1074\/jbc.M204016200_bib39","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1161\/hq1201.100242","volume":"21","author":"Huang","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1074\/jbc.M204016200_bib40","doi-asserted-by":"crossref","first-page":"8592","DOI":"10.1073\/pnas.91.18.8592","volume":"91","author":"Bj\u00f6rkhem","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M204016200_bib41","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0021-9150(00)00473-1","volume":"154","author":"Shanahan","year":"2001","journal-title":"Atherosclerosis"},{"key":"10.1074\/jbc.M204016200_bib42","doi-asserted-by":"crossref","first-page":"44258","DOI":"10.1074\/jbc.M108482200","volume":"276","author":"Vosper","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204016200_bib43","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/ncb1001-905","volume":"3","author":"Puglielli","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M204016200_bib44","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/343531a0","volume":"343","author":"Kodama","year":"1990","journal-title":"Nature"},{"key":"10.1074\/jbc.M204016200_bib45","doi-asserted-by":"crossref","first-page":"11811","DOI":"10.1016\/S0021-9258(19)50272-1","volume":"268","author":"Endemann","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204016200_bib46","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1172\/JCI9259","volume":"105","author":"Febbraio","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M204016200_bib47","doi-asserted-by":"crossref","first-page":"21003","DOI":"10.1016\/S0021-9258(17)31921-X","volume":"269","author":"Acton","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M204016200_bib48","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/83328","volume":"7","author":"Moore","year":"2001","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M204016200_bib49","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0092-8674(00)81575-5","volume":"93","author":"Tontonoz","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.M204016200_bib50","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/S0022-2275(20)32118-0","volume":"40","author":"Han","year":"1999","journal-title":"J. Lipid Res."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820700451?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820700451?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M204016200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T12:36:30Z","timestamp":1641386190000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820700451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":50,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["S0021925820700451"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m204016200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2002,8]]}}}