{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:46:47Z","timestamp":1771469207481,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T00:00:00Z","timestamp":1602374400000},"content-version":"vor","delay-in-days":6342,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2003,6]]},"DOI":"10.1074\/jbc.m301418200","type":"journal-article","created":{"date-parts":[[2003,5,30]],"date-time":"2003-05-30T18:47:07Z","timestamp":1054320427000},"page":"21099-21104","update-policy":"https:\/\/doi.org\/10.1074\/jbc.f110.005975","source":"Crossref","is-referenced-by-count":90,"title":["The Pleckstrin Homology Domain of Phospholipase C-\u03b22 as an Effector Site for Rac"],"prefix":"10.1016","volume":"278","author":[{"given":"Jason T.","family":"Snyder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex U.","family":"Singer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele R.","family":"Wing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Kendall","family":"Harden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Sondek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M301418200_bib1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1152\/physrev.2000.80.4.1291","volume":"80","author":"Rebecchi","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M301418200_bib2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev.biochem.70.1.281","volume":"70","author":"Rhee","year":"2001","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M301418200_bib3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1042\/bj2200345","volume":"220","author":"Berridge","year":"1984","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M301418200_bib4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/309063a0","volume":"309","author":"Burgess","year":"1984","journal-title":"Nature"},{"key":"10.1074\/jbc.M301418200_bib5","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/emboj\/20.4.743","volume":"20","author":"Kelley","year":"2001","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M301418200_bib6","doi-asserted-by":"crossref","first-page":"48257","DOI":"10.1074\/jbc.C100574200","volume":"276","author":"Wing","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.3006254","volume":"232","author":"Smith","year":"1986","journal-title":"Science"},{"key":"10.1074\/jbc.M301418200_bib8","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/350516a0","volume":"350","author":"Taylor","year":"1991","journal-title":"Nature"},{"key":"10.1074\/jbc.M301418200_bib9","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1126\/science.1846707","volume":"251","author":"Smrcka","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.M301418200_bib10","doi-asserted-by":"crossref","first-page":"14217","DOI":"10.1016\/S0021-9258(18)98670-9","volume":"266","author":"Waldo","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib11","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1432-1033.1992.tb16990.x","volume":"206","author":"Camps","year":"1992","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M301418200_bib12","doi-asserted-by":"crossref","first-page":"25451","DOI":"10.1016\/S0021-9258(19)74062-9","volume":"267","author":"Boyer","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib13","doi-asserted-by":"crossref","first-page":"23069","DOI":"10.1016\/S0021-9258(18)50057-0","volume":"267","author":"Blank","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib14","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1002\/j.1460-2075.1995.tb00057.x","volume":"14","author":"Heinz","year":"1995","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M301418200_bib15","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0092-8674(95)90219-8","volume":"83","author":"Ferguson","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.M301418200_bib16","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/380595a0","volume":"380","author":"Essen","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.M301418200_bib17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nsb731","volume":"9","author":"Singer","year":"2002","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M301418200_bib18","doi-asserted-by":"crossref","first-page":"26622","DOI":"10.1074\/jbc.271.43.26622","volume":"271","author":"Paulssen","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib19","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1073\/pnas.93.7.2964","volume":"93","author":"Kuang","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M301418200_bib20","doi-asserted-by":"crossref","first-page":"7148","DOI":"10.1074\/jbc.273.12.7148","volume":"273","author":"Sankaran","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib21","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1021\/bi982008f","volume":"38","author":"Wang","year":"1999","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M301418200_bib22","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1021\/bi992021f","volume":"39","author":"Barr","year":"2000","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M301418200_bib23","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1074\/jbc.275.11.7466","volume":"275","author":"Wang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib24","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1021\/bi9821519","volume":"38","author":"Runnels","year":"1999","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M301418200_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3500001","volume":"350","author":"Lemmon","year":"2000","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M301418200_bib26","doi-asserted-by":"crossref","first-page":"16228","DOI":"10.1021\/bi00049a039","volume":"34","author":"Garcia","year":"1995","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M301418200_bib27","doi-asserted-by":"crossref","first-page":"7092","DOI":"10.1021\/bi025625j","volume":"41","author":"Scarlata","year":"2002","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M301418200_bib28","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1093\/emboj\/17.21.6241","volume":"17","author":"Illenberger","year":"1998","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M301418200_bib29","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1074\/jbc.M208282200","volume":"278","author":"Illenberger","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib30","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.279.5350.509","volume":"279","author":"Hall","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.M301418200_bib31","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature01148","volume":"420","author":"Etienne-Manneville","year":"2002","journal-title":"Nature"},{"key":"10.1074\/jbc.M301418200_bib32","doi-asserted-by":"crossref","first-page":"8645","DOI":"10.1074\/jbc.M211971200","volume":"278","author":"Illenberger","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib33","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/nsb796","volume":"9","author":"Snyder","year":"2002","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M301418200_bib34","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1110\/ps.4330102","volume":"11","author":"Day","year":"2002","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.M301418200_bib35","doi-asserted-by":"crossref","first-page":"49267","DOI":"10.1074\/jbc.M106565200","volume":"276","author":"Blake","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib36","first-page":"648","volume":"40","author":"Brown","year":"1991","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M301418200_bib37","doi-asserted-by":"crossref","first-page":"13771","DOI":"10.1016\/S0021-9258(17)36714-5","volume":"269","author":"Remmers","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib38","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0092-8674(90)90018-A","volume":"62","author":"Krengel","year":"1990","journal-title":"Cell"},{"key":"10.1074\/jbc.M301418200_bib39","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0958-1669(97)80157-7","volume":"8","author":"Myszka","year":"1997","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1074\/jbc.M301418200_bib40","doi-asserted-by":"crossref","first-page":"30497","DOI":"10.1074\/jbc.273.46.30497","volume":"273","author":"Kavran","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib41","doi-asserted-by":"crossref","first-page":"11707","DOI":"10.1074\/jbc.270.20.11707","volume":"270","author":"Pitcher","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib42","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1432-1033.1997.t01-1-00071.x","volume":"246","author":"Illenberger","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M301418200_bib43","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1093\/nar\/25.24.4876","volume":"25","author":"Thompson","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M301418200_bib44","doi-asserted-by":"crossref","first-page":"17000","DOI":"10.1074\/jbc.270.28.17000","volume":"270","author":"Touhara","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib45","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0167-4889(96)00109-7","volume":"1314","author":"Abrams","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M301418200_bib46","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF02578386","volume":"16","author":"Xu","year":"1996","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1074\/jbc.M301418200_bib47","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1248\/bpb.22.229","volume":"22","author":"Sawai","year":"1999","journal-title":"Biol. Pharm. Bull."},{"key":"10.1074\/jbc.M301418200_bib48","doi-asserted-by":"crossref","first-page":"9111","DOI":"10.1021\/bi00028a021","volume":"34","author":"Mahadevan","year":"1995","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M301418200_bib49","doi-asserted-by":"crossref","first-page":"16824","DOI":"10.1021\/bi961606w","volume":"35","author":"Runnels","year":"1996","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M301418200_bib50","doi-asserted-by":"crossref","first-page":"45868","DOI":"10.1074\/jbc.M106731200","volume":"276","author":"Snyder","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib51","doi-asserted-by":"crossref","first-page":"11457","DOI":"10.1074\/jbc.M211901200","volume":"278","author":"Baumeister","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib52","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0014-5793(02)03411-7","volume":"531","author":"Philip","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M301418200_bib53","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/75158","volume":"7","author":"Morreale","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M301418200_bib54","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/20732","volume":"399","author":"Mott","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M301418200_bib55","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/20726","volume":"399","author":"Abdul-Manan","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M301418200_bib56","doi-asserted-by":"crossref","first-page":"30066","DOI":"10.1074\/jbc.M201713200","volume":"277","author":"Kim","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M301418200_bib57","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/17969","volume":"398","author":"Vetter","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M301418200_bib58","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0968-0004(99)01472-3","volume":"24","author":"Blomberg","year":"1999","journal-title":"Trends Biochem. Sci."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820734186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820734186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M301418200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T14:40:39Z","timestamp":1641393639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820734186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":58,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["S0021925820734186"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m301418200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,6]]}}}