{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:46:12Z","timestamp":1778661972000,"version":"3.51.4"},"reference-count":58,"publisher":"Elsevier BV","issue":"41","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":6206,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2003,10]]},"DOI":"10.1074\/jbc.m304482200","type":"journal-article","created":{"date-parts":[[2003,10,3]],"date-time":"2003-10-03T18:28:46Z","timestamp":1065205726000},"page":"39773-39781","source":"Crossref","is-referenced-by-count":30,"title":["Resistance of the Human \u03b21-Adrenergic Receptor to Agonist-mediated Down-regulation"],"prefix":"10.1016","volume":"278","author":[{"given":"Wei","family":"Liang","sequence":"first","affiliation":[]},{"given":"Steven","family":"Austin","sequence":"additional","affiliation":[]},{"given":"Quang","family":"Hoang","sequence":"additional","affiliation":[]},{"given":"Peter H.","family":"Fishman","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1074\/jbc.M304482200_bib1","first-page":"577","volume":"60","author":"Devic","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M304482200_bib2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/01.RES.87.8.635","volume":"87","author":"Xiao","year":"2000","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M304482200_bib3","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1073\/pnas.98.4.1607","volume":"98","author":"Zhu","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M304482200_bib4","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1161\/01.CIR.100.22.2210","volume":"100","author":"Communal","year":"1999","journal-title":"Circulation"},{"key":"10.1074\/jbc.M304482200_bib5","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1006\/jmcc.2001.1358","volume":"33","author":"Port","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1074\/jbc.M304482200_bib6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0165-6147(00)01620-5","volume":"22","author":"Tsao","year":"2001","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1074\/jbc.M304482200_bib7","doi-asserted-by":"crossref","first-page":"6976","DOI":"10.1074\/jbc.273.12.6976","volume":"273","author":"Gagnon","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1242\/jcs.112.3.329","volume":"112","author":"Moore","year":"1999","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M304482200_bib9","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1073\/pnas.87.13.5089","volume":"87","author":"Valiquette","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M304482200_bib10","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1073\/pnas.88.8.2979","volume":"88","author":"Hausdorff","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M304482200_bib11","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1016\/S0021-9258(17)42012-6","volume":"269","author":"Barak","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib12","doi-asserted-by":"crossref","first-page":"9414","DOI":"10.1021\/bi00198a006","volume":"33","author":"Green","year":"1994","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M304482200_bib13","doi-asserted-by":"crossref","first-page":"28900","DOI":"10.1074\/jbc.274.41.28900","volume":"274","author":"Jockers","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib14","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1124\/mol.58.2.421","volume":"58","author":"Williams","year":"2000","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M304482200_bib15","doi-asserted-by":"crossref","first-page":"16786","DOI":"10.1016\/S0021-9258(19)84774-9","volume":"264","author":"Bouvier","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib16","doi-asserted-by":"crossref","first-page":"24103","DOI":"10.1016\/S0021-9258(18)35952-0","volume":"267","author":"Port","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib17","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1074\/jbc.273.6.3223","volume":"273","author":"Danner","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib18","doi-asserted-by":"crossref","first-page":"4290","DOI":"10.1074\/jbc.275.6.4290","volume":"275","author":"Blaxall","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib19","first-page":"657","volume":"235","author":"Neve","year":"1985","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M304482200_bib20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3109\/10799899409066037","volume":"14","author":"Fishman","year":"1994","journal-title":"J. Recep. Res."},{"key":"10.1074\/jbc.M304482200_bib21","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1042\/bj3170925","volume":"317","author":"Dangel","year":"1996","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M304482200_bib22","first-page":"271","volume":"249","author":"Valet","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M304482200_bib23","doi-asserted-by":"crossref","first-page":"H1762","DOI":"10.1152\/ajpcell.1996.271.5.C1512","volume":"271","author":"Zhao","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M304482200_bib24","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1161\/01.RES.59.3.297","volume":"59","author":"Bristow","year":"1986","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.M304482200_bib25","first-page":"542","volume":"41","author":"Suzuki","year":"1992","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M304482200_bib26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0898-6568(94)00091-O","volume":"7","author":"Zhou","year":"1995","journal-title":"Cell. Signal."},{"key":"10.1074\/jbc.M304482200_bib27","doi-asserted-by":"crossref","first-page":"8019","DOI":"10.1021\/bi025538r","volume":"41","author":"Dunigan","year":"2002","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M304482200_bib28","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1038\/sj.bjp.0703506","volume":"130","author":"McLean","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1074\/jbc.M304482200_bib29","doi-asserted-by":"crossref","first-page":"30429","DOI":"10.1074\/jbc.M200681200","volume":"277","author":"Levin","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00005344-200202000-00001","volume":"39","author":"Rathz","year":"2002","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1074\/jbc.M304482200_bib31","doi-asserted-by":"crossref","first-page":"26215","DOI":"10.1016\/S0021-9258(18)47181-5","volume":"269","author":"Green","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib32","doi-asserted-by":"crossref","first-page":"29082","DOI":"10.1074\/jbc.M909757199","volume":"275","author":"Shiina","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib33","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1074\/jbc.274.4.2216","volume":"274","author":"Trejo","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib34","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/45816","volume":"401","author":"Cao","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M304482200_bib35","doi-asserted-by":"crossref","first-page":"13096","DOI":"10.1074\/jbc.M009780200","volume":"276","author":"Innamorati","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib36","doi-asserted-by":"crossref","first-page":"44712","DOI":"10.1074\/jbc.M107417200","volume":"276","author":"Gage","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib37","first-page":"329","volume":"126","author":"Dunigan","year":"2000","journal-title":"Methods Mol. Biol."},{"key":"10.1074\/jbc.M304482200_bib38","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1242\/jcs.113.13.2463","volume":"113","author":"Santini","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M304482200_bib39","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1126\/science.271.5247.363","volume":"271","author":"Ferguson","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.M304482200_bib40","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/383447a0","volume":"383","author":"Goodman","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.M304482200_bib41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1146\/annurev.pa.27.040187.001243","volume":"27","author":"Mahan","year":"1987","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1074\/jbc.M304482200_bib42","first-page":"878","volume":"45","author":"Zhang","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M304482200_bib43","first-page":"104","volume":"30","author":"Neve","year":"1986","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M304482200_bib44","doi-asserted-by":"crossref","first-page":"C41","DOI":"10.1152\/ajpcell.1990.259.1.C41","volume":"259","author":"Jasper","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.M304482200_bib45","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/(SICI)1097-4644(19991001)75:1<64::AID-JCB7>3.0.CO;2-L","volume":"75","author":"Schwencke","year":"1999","journal-title":"J. Cell. Biochem."},{"key":"10.1074\/jbc.M304482200_bib46","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1083\/jcb.141.1.85","volume":"141","author":"Henley","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M304482200_bib47","first-page":"192","volume":"39","author":"Campbell","year":"1991","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M304482200_bib48","doi-asserted-by":"crossref","first-page":"38659","DOI":"10.1074\/jbc.M005938200","volume":"275","author":"Hu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib49","doi-asserted-by":"crossref","first-page":"41310","DOI":"10.1074\/jbc.M107480200","volume":"276","author":"Xu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib50","doi-asserted-by":"crossref","first-page":"33783","DOI":"10.1074\/jbc.M204136200","volume":"277","author":"Xiang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib51","first-page":"752","volume":"49","author":"Rousseau","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M304482200_bib52","doi-asserted-by":"crossref","first-page":"33019","DOI":"10.1074\/jbc.M100140200","volume":"276","author":"Shiina","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304482200_bib53","doi-asserted-by":"crossref","first-page":"12559","DOI":"10.1073\/pnas.96.22.12559","volume":"96","author":"Tang","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M304482200_bib54","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0898-6568(96)00068-X","volume":"8","author":"Curran","year":"1996","journal-title":"Cell. Signal."},{"key":"10.1074\/jbc.M304482200_bib55","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1126\/science.1073308","volume":"297","author":"Whistler","year":"2002","journal-title":"Science"},{"key":"10.1074\/jbc.M304482200_bib56","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1091\/mbc.e01-11-0131","volume":"13","author":"Wang","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M304482200_bib57","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1124\/mol.51.5.800","volume":"51","author":"Menard","year":"1997","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.M304482200_bib58","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1126\/science.1063866","volume":"294","author":"Shenoy","year":"2001","journal-title":"Science"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820830270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820830270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M304482200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T22:10:57Z","timestamp":1704924657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820830270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":58,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["S0021925820830270"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m304482200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,10]]}}}