{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T02:40:53Z","timestamp":1779158453941,"version":"3.51.4"},"reference-count":59,"publisher":"Elsevier BV","issue":"33","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":6270,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2003,8]]},"DOI":"10.1074\/jbc.m304824200","type":"journal-article","created":{"date-parts":[[2003,8,8]],"date-time":"2003-08-08T18:26:19Z","timestamp":1060367179000},"page":"30748-30754","source":"Crossref","is-referenced-by-count":100,"title":["A\u03b242-lowering Nonsteroidal Anti-inflammatory Drugs Preserve Intramembrane Cleavage of the Amyloid Precursor Protein (APP) and ErbB-4 Receptor and Signaling through the APP Intracellular Domain"],"prefix":"10.1016","volume":"278","author":[{"given":"Sascha","family":"Weggen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason L.","family":"Eriksen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Sagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus U.","family":"Pietrzik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd.E.","family":"Golde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward H.","family":"Koo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.M304824200_bib1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0092-8674(00)80675-3","volume":"100","author":"Brown","year":"2000","journal-title":"Cell"},{"key":"10.1074\/jbc.M304824200_bib2","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/19083","volume":"398","author":"De Strooper","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M304824200_bib3","doi-asserted-by":"crossref","first-page":"40268","DOI":"10.1074\/jbc.M107234200","volume":"276","author":"Saxena","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib4","doi-asserted-by":"crossref","first-page":"7751","DOI":"10.1074\/jbc.C200711200","volume":"278","author":"Ikeuchi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/34910","volume":"391","author":"De Strooper","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M304824200_bib6","doi-asserted-by":"crossref","first-page":"44195","DOI":"10.1074\/jbc.M208110200","volume":"277","author":"Scheinfeld","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib7","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1126\/science.1065412","volume":"294","author":"Ni","year":"2001","journal-title":"Science"},{"key":"10.1074\/jbc.M304824200_bib8","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.1074\/jbc.M110371200","volume":"277","author":"Lee","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib9","doi-asserted-by":"crossref","first-page":"18736","DOI":"10.1074\/jbc.M201979200","volume":"277","author":"May","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib10","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1093\/emboj\/21.8.1948","volume":"21","author":"Marambaud","year":"2002","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M304824200_bib11","doi-asserted-by":"crossref","first-page":"44754","DOI":"10.1074\/jbc.M206872200","volume":"277","author":"Lammich","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib12","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/sj.onc.1206298","volume":"22","author":"Murakami","year":"2003","journal-title":"Oncogene"},{"key":"10.1074\/jbc.M304824200_bib13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1006\/dbio.2000.9960","volume":"228","author":"Mumm","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1074\/jbc.M304824200_bib14","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.cellbio.18.020402.142302","volume":"18","author":"Annaert","year":"2002","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1074\/jbc.M304824200_bib15","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/30756","volume":"393","author":"Schroeter","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M304824200_bib16","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.M304824200_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nrn785","volume":"3","author":"Sisodia","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1074\/jbc.M304824200_bib18","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1093\/emboj\/cdf541","volume":"21","author":"Okochi","year":"2002","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M304824200_bib19","doi-asserted-by":"crossref","first-page":"35235","DOI":"10.1074\/jbc.C100357200","volume":"276","author":"Gu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib20","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/embo-reports\/kve180","volume":"2","author":"Sastre","year":"2001","journal-title":"EMBO Rep."},{"key":"10.1074\/jbc.M304824200_bib21","doi-asserted-by":"crossref","first-page":"43756","DOI":"10.1074\/jbc.C100410200","volume":"276","author":"Yu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib22","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1021\/bi015794o","volume":"41","author":"Weidemann","year":"2002","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M304824200_bib23","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1034\/j.1600-0854.2002.31101.x","volume":"3","author":"Koo","year":"2002","journal-title":"Traffic"},{"key":"10.1074\/jbc.M304824200_bib24","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0962-8924(02)02394-2","volume":"12","author":"Haass","year":"2002","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.M304824200_bib25","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nrd938","volume":"1","author":"Wolfe","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1074\/jbc.M304824200_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1172\/JCI200317527","volume":"111","author":"Golde","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.M304824200_bib27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1534-5807(02)00189-2","volume":"3","author":"Francis","year":"2002","journal-title":"Dev. Cell."},{"key":"10.1074\/jbc.M304824200_bib28","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/35024009","volume":"407","author":"Yu","year":"2000","journal-title":"Nature"},{"key":"10.1074\/jbc.M304824200_bib29","doi-asserted-by":"crossref","first-page":"39062","DOI":"10.1074\/jbc.C200469200","volume":"277","author":"Steiner","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib30","doi-asserted-by":"crossref","first-page":"45013","DOI":"10.1074\/jbc.M208164200","volume":"277","author":"Lee","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib31","doi-asserted-by":"crossref","first-page":"7374","DOI":"10.1074\/jbc.M209499200","volume":"278","author":"Gu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib32","doi-asserted-by":"crossref","first-page":"7850","DOI":"10.1074\/jbc.C200648200","volume":"278","author":"Luo","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib33","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nature01506","volume":"422","author":"Takasugi","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M304824200_bib34","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/ncb960","volume":"5","author":"Edbauer","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M304824200_bib35","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1124\/jpet.102.048280","volume":"305","author":"Lanz","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.M304824200_bib36","doi-asserted-by":"crossref","first-page":"7487","DOI":"10.1073\/pnas.131202798","volume":"98","author":"Hadland","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M304824200_bib37","doi-asserted-by":"crossref","first-page":"9312","DOI":"10.1073\/pnas.161102498","volume":"98","author":"Doerfler","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M304824200_bib38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1096\/fj.02-0394fje","volume":"17","author":"Micchelli","year":"2003","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M304824200_bib39","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/embo-reports\/kvf124","volume":"3","author":"Geling","year":"2002","journal-title":"EMBO Rep."},{"key":"10.1074\/jbc.M304824200_bib40","doi-asserted-by":"crossref","first-page":"16528","DOI":"10.1074\/jbc.M301372200","volume":"278","author":"Weihofen","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"suppl.","key":"10.1074\/jbc.M304824200_bib41","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/nn940","volume":"5","author":"Citron","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1074\/jbc.M304824200_bib42","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/35102591","volume":"414","author":"Weggen","year":"2001","journal-title":"Nature"},{"key":"10.1074\/jbc.M304824200_bib43","doi-asserted-by":"crossref","first-page":"18664","DOI":"10.1074\/jbc.M301619200","volume":"278","author":"Takahashi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib44","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1523\/JNEUROSCI.13-07-03136.1993","volume":"13","author":"Sisodia","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M304824200_bib45","doi-asserted-by":"crossref","first-page":"7952","DOI":"10.1074\/jbc.274.12.7952","volume":"274","author":"Sabo","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib46","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1126\/science.1058783","volume":"293","author":"Cao","year":"2001","journal-title":"Science"},{"key":"10.1074\/jbc.M304824200_bib47","doi-asserted-by":"crossref","first-page":"18989","DOI":"10.1074\/jbc.271.31.18989","volume":"271","author":"Vecchi","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib48","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1096\/fj.00-0286fje","volume":"14","author":"McLendon","year":"2000","journal-title":"FASEB J."},{"key":"10.1074\/jbc.M304824200_bib49","doi-asserted-by":"crossref","first-page":"40288","DOI":"10.1074\/jbc.C100447200","volume":"276","author":"Kimberly","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib50","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1074\/jbc.M210504200","volume":"278","author":"Ni","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib51","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0092-8674(02)00809-7","volume":"110","author":"Baek","year":"2002","journal-title":"Cell"},{"key":"10.1074\/jbc.M304824200_bib52","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1046\/j.1471-4159.2001.00516.x","volume":"78","author":"Cupers","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M304824200_bib53","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1074\/jbc.M304824200_bib54","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1056\/NEJMoa010178","volume":"345","author":"in t' Veld","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M304824200_bib55","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1523\/JNEUROSCI.20-15-05709.2000","volume":"20","author":"Lim","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.M304824200_bib56","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1046\/j.1471-4159.2002.01195.x","volume":"83","author":"Morihara","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M304824200_bib57","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1006\/nbdi.2000.0322","volume":"7","author":"Xia","year":"2000","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.M304824200_bib58","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.1074\/jbc.M209252200","volume":"278","author":"Ikeuchi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M304824200_bib59","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1096\/fj.01-0390rev","volume":"15","author":"Tegeder","year":"2001","journal-title":"FASEB J."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820841064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820841064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M304824200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T21:11:17Z","timestamp":1641417077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820841064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8]]},"references-count":59,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["S0021925820841064"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m304824200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2003,8]]}}}