{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:25:04Z","timestamp":1776723904592,"version":"3.51.2"},"reference-count":55,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":6042,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1074\/jbc.m313062200","type":"journal-article","created":{"date-parts":[[2004,4,2]],"date-time":"2004-04-02T22:18:24Z","timestamp":1080944304000},"page":"14752-14762","source":"Crossref","is-referenced-by-count":214,"title":["TOR Complex 1 Includes a Novel Component, Tco89p (YPL180w), and Cooperates with Ssd1p to Maintain Cellular Integrity in Saccharomyces cerevisiae"],"prefix":"10.1016","volume":"279","author":[{"given":"Aaron","family":"Reinke","sequence":"first","affiliation":[]},{"given":"Scott","family":"Anderson","sequence":"additional","affiliation":[]},{"given":"J. Michael","family":"McCaffery","sequence":"additional","affiliation":[]},{"suffix":"III","given":"John","family":"Yates","sequence":"additional","affiliation":[]},{"given":"Sofia","family":"Aronova","sequence":"additional","affiliation":[]},{"given":"Stephanie","family":"Chu","sequence":"additional","affiliation":[]},{"given":"Stephen","family":"Fairclough","sequence":"additional","affiliation":[]},{"given":"Cory","family":"Iverson","sequence":"additional","affiliation":[]},{"given":"Karen P.","family":"Wedaman","sequence":"additional","affiliation":[]},{"given":"Ted","family":"Powers","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1074\/jbc.M313062200_bib1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0959-437X(99)80007-0","volume":"9","author":"Dennis","year":"1999","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1074\/jbc.M313062200_bib2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0092-8674(00)00117-3","volume":"103","author":"Schmelzle","year":"2000","journal-title":"Cell"},{"key":"10.1074\/jbc.M313062200_bib3","doi-asserted-by":"crossref","first-page":"7037","DOI":"10.1073\/pnas.121145898","volume":"98","author":"Raught","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M313062200_bib4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1128\/MCB.23.2.629-635.2003","volume":"23","author":"Rhode","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M313062200_bib5","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1128\/MMBR.66.4.579-591.2002","volume":"66","author":"Crespo","year":"2003","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1074\/jbc.M313062200_bib6","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1101\/gad.10.15.1904","volume":"10","author":"Di Como","year":"1996","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M313062200_bib7","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1093\/emboj\/18.10.2782","volume":"18","author":"Jiang","year":"1999","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M313062200_bib8","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S1097-2765(01)00386-0","volume":"8","author":"Jacinto","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M313062200_bib9","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S1097-2765(03)00228-4","volume":"11","author":"D\u00fcvel","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M313062200_bib10","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/45287","volume":"402","author":"Beck","year":"1999","journal-title":"Nature"},{"key":"10.1074\/jbc.M313062200_bib11","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/S0960-9822(00)00866-6","volume":"10","author":"Shamji","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M313062200_bib12","doi-asserted-by":"crossref","first-page":"13780","DOI":"10.1073\/pnas.93.24.13780","volume":"93","author":"Schmidt","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M313062200_bib13","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0092-8674(00)81893-0","volume":"88","author":"Schmidt","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.M313062200_bib14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/genetics\/148.1.99","volume":"148","author":"Helliwell","year":"1998","journal-title":"Genetics"},{"key":"10.1074\/jbc.M313062200_bib15","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1242\/jcs.113.4.571","volume":"113","author":"Pruyne","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.M313062200_bib16","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1046\/j.1365-2958.1999.01375.x","volume":"32","author":"Heinisch","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M313062200_bib17","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1128\/MCB.22.5.1329-1339.2002","volume":"22","author":"Schmelzle","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M313062200_bib18","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1046\/j.1365-2958.2002.02925.x","volume":"44","author":"Schmitz","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M313062200_bib19","doi-asserted-by":"crossref","first-page":"33468","DOI":"10.1074\/jbc.M203515200","volume":"277","author":"Angeles de la Torre-Ruiz","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M313062200_bib20","doi-asserted-by":"crossref","first-page":"43495","DOI":"10.1074\/jbc.M205408200","volume":"277","author":"Torres","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M313062200_bib21","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/genetics\/160.1.83","volume":"160","author":"Kaeberlein","year":"2002","journal-title":"Genetics"},{"key":"10.1074\/jbc.M313062200_bib22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1097-2765(02)00636-6","volume":"10","author":"Loewith","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M313062200_bib23","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0092-8674(02)00833-4","volume":"110","author":"Hara","year":"2002","journal-title":"Cell"},{"key":"10.1074\/jbc.M313062200_bib24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0092-8674(02)00808-5","volume":"110","author":"Kim","year":"2002","journal-title":"Cell"},{"key":"10.1074\/jbc.M313062200_bib25","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S1097-2765(03)00114-X","volume":"11","author":"Kim","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M313062200_bib26","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1091\/mbc.e02-09-0609","volume":"14","author":"Wedaman","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M313062200_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.200210141","volume":"161","author":"Chen","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M313062200_bib28","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0076-6879(91)94005-W","volume":"194","author":"Sherman","year":"1991","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M313062200_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0076-6879(91)94004-V","volume":"194","author":"Sherman","year":"1991","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M313062200_bib30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0076-6879(02)50957-5","volume":"350","author":"Gietz","year":"2002","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M313062200_bib31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/(SICI)1097-0061(19980130)14:2<115::AID-YEA204>3.0.CO;2-2","volume":"14","author":"Brachmann","year":"1998","journal-title":"Yeast"},{"key":"10.1074\/jbc.M313062200_bib32","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/(SICI)1097-0061(199807)14:10<953::AID-YEA293>3.0.CO;2-U","volume":"14","author":"Longtine","year":"1998","journal-title":"Yeast"},{"key":"10.1074\/jbc.M313062200_bib33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/genetics\/122.1.19","volume":"122","author":"Sikorski","year":"1989","journal-title":"Genetics"},{"key":"10.1074\/jbc.M313062200_bib34","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1091\/mbc.7.6.985","volume":"7","author":"Rieder","year":"1996","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M313062200_bib35","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1083\/jcb.143.3.709","volume":"143","author":"Carroll","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.M313062200_bib36","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/10890","volume":"17","author":"Link","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"10.1074\/jbc.M313062200_bib37","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1073\/pnas.061034498","volume":"98","author":"Ito","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M313062200_bib38","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1091\/mbc.10.4.987","volume":"10","author":"Powers","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M313062200_bib39","doi-asserted-by":"crossref","first-page":"14866","DOI":"10.1073\/pnas.96.26.14866","volume":"96","author":"Hardwick","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M313062200_bib40","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1101\/gad.13.24.3271","volume":"13","author":"Cardenas","year":"1999","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M313062200_bib41","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1099\/00221287-146-9-2121","volume":"146","author":"de Nobel","year":"2000","journal-title":"Microbiology"},{"key":"10.1074\/jbc.M313062200_bib42","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1101\/gad.9.13.1559","volume":"9","author":"Kamada","year":"1995","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M313062200_bib43","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1128\/JB.182.9.2428-2437.2000","volume":"182","author":"Garcia-Rodriguez","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.M313062200_bib44","first-page":"2133","volume":"11","author":"Sutton","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M313062200_bib45","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/genetics\/145.2.227","volume":"145","author":"Evans","year":"1997","journal-title":"Genetics"},{"key":"10.1074\/jbc.M313062200_bib46","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1101\/gad.10.3.279","volume":"10","author":"Alarcon","year":"1996","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M313062200_bib47","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1091\/mbc.10.8.2531","volume":"10","author":"Alarcon","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1074\/jbc.M313062200_bib48","doi-asserted-by":"crossref","first-page":"16103","DOI":"10.1074\/jbc.272.26.16103","volume":"272","author":"Uesono","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M313062200_bib49","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S0960-9822(02)00760-1","volume":"12","author":"Krause","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M313062200_bib50","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0168-9525(93)90042-G","volume":"9","author":"Guarente","year":"1993","journal-title":"Trends Genet."},{"key":"10.1074\/jbc.M313062200_bib51","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nature02026","volume":"425","author":"Huh","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M313062200_bib52","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1046\/j.1365-2958.2000.01968.x","volume":"37","author":"Holst","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.M313062200_bib53","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nature02046","volume":"425","author":"Ghaemmaghami","year":"2003","journal-title":"Nature"},{"key":"10.1074\/jbc.M313062200_bib54","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0092-8674(90)90110-Z","volume":"62","author":"Nasmyth","year":"1990","journal-title":"Cell"},{"key":"10.1074\/jbc.M313062200_bib55","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0092-8674(93)90144-F","volume":"73","author":"Kunz","year":"1993","journal-title":"Cell"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819638676?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819638676?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M313062200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T01:55:06Z","timestamp":1641174906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819638676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":55,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S0021925819638676"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m313062200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}