{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:50:02Z","timestamp":1767901802345,"version":"3.49.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"49","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":5422,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1074\/jbc.m507528200","type":"journal-article","created":{"date-parts":[[2005,9,27]],"date-time":"2005-09-27T00:12:43Z","timestamp":1127779963000},"page":"41101-41110","update-policy":"https:\/\/doi.org\/10.1074\/jbc.f110.005975","source":"Crossref","is-referenced-by-count":80,"title":["Structure of Human Phytanoyl-CoA 2-Hydroxylase Identifies Molecular Mechanisms of Refsum Disease*"],"prefix":"10.1016","volume":"280","author":[{"given":"Michael A.","family":"McDonough","sequence":"first","affiliation":[]},{"given":"Kathryn L.","family":"Kavanagh","sequence":"additional","affiliation":[]},{"given":"Danica","family":"Butler","sequence":"additional","affiliation":[]},{"given":"Timothy","family":"Searls","sequence":"additional","affiliation":[]},{"given":"Udo","family":"Oppermann","sequence":"additional","affiliation":[]},{"given":"Christopher J.","family":"Schofield","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1074\/jbc.M507528200_bib1","series-title":"The Metabolic and Molecular Bases of Inherited Disease","first-page":"2351","author":"Steinberg","year":"1995"},{"key":"10.1074\/jbc.M507528200_bib2","first-page":"3303","volume":"2","author":"Wanders","year":"2001"},{"key":"10.1074\/jbc.M507528200_bib3","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1046\/j.0022-3042.2002.00766.x","volume":"80","author":"Wierzbicki","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1074\/jbc.M507528200_bib4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0163-7827(03)00016-X","volume":"42","author":"Mukherji","year":"2003","journal-title":"Prog. Lipid Res."},{"key":"10.1074\/jbc.M507528200_bib5","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/ng1097-190","volume":"17","author":"Jansen","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M507528200_bib6","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/ng1097-185","volume":"17","author":"Mihalik","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.M507528200_bib7","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1086\/346093","volume":"72","author":"van den Brink","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1074\/jbc.M507528200_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/humu.10315","volume":"23","author":"Jansen","year":"2004","journal-title":"Hum. Mutat."},{"key":"10.1074\/jbc.M507528200_bib9","series-title":"Handbook of Ataxia Disorders","first-page":"235","author":"Gibberd","year":"2000"},{"key":"10.1074\/jbc.M507528200_bib10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1259\/0007-1285-63-751-537","volume":"63","author":"Plant","year":"1990","journal-title":"Br. J. Radiol."},{"key":"10.1074\/jbc.M507528200_bib11","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1073\/pnas.96.5.2104","volume":"96","author":"Chambraud","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M507528200_bib12","doi-asserted-by":"crossref","first-page":"46340","DOI":"10.1074\/jbc.M106124200","volume":"276","author":"Chen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M507528200_bib13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0169-328X(99)00304-6","volume":"75","author":"Lee","year":"2000","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1074\/jbc.M507528200_bib14","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0169-328X(01)00004-3","volume":"87","author":"Koh","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1074\/jbc.M507528200_bib15","doi-asserted-by":"crossref","first-page":"26838","DOI":"10.1074\/jbc.M501861200","volume":"280","author":"van den Brink","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M507528200_bib16","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1039\/a902197c","volume":"17","author":"Prescott","year":"2000","journal-title":"Nat. Prod. Rep."},{"key":"10.1074\/jbc.M507528200_bib17","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1432-1033.1995.545zz.x","volume":"232","author":"Mihalik","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M507528200_bib18","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0022-2275(20)32139-8","volume":"40","author":"Croes","year":"1999","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M507528200_bib19","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1016\/S0960-894X(01)00494-2","volume":"11","author":"Kershaw","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1074\/jbc.M507528200_bib20","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S1388-1981(99)00126-2","volume":"1440","author":"Jansen","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M507528200_bib21","doi-asserted-by":"crossref","first-page":"10039","DOI":"10.1073\/pnas.96.18.10039","volume":"96","author":"Foulon","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M507528200_bib22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0014-5793(97)00343-8","volume":"407","author":"Croes","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M507528200_bib23","first-page":"33","volume":"327","author":"van Veldhoven","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M507528200_bib24","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1006\/bbrc.1999.0510","volume":"2257","author":"Steinberg","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M507528200_bib25","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1432-1033.1994.tb18870.x","volume":"222","author":"Schmitz","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M507528200_bib26","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1432-1033.1995.tb20766.x","volume":"231","author":"Schmitz","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M507528200_bib27","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1194\/jlr.M500034-JLR200","volume":"46","author":"Searls","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1074\/jbc.M507528200_bib28","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S1074-5521(02)00139-4","volume":"9","author":"Mukherji","year":"2002","journal-title":"Chem. Biol."},{"key":"10.1074\/jbc.M507528200_bib29","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1093\/hmg\/10.18.1971","volume":"10","author":"Mukherji","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M507528200_bib30","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/29575","volume":"394","author":"Valegard","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.M507528200_bib31","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1074\/jbc.C200644200","volume":"278","author":"Elkins","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M507528200_bib32","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1006\/bbrc.1999.1957","volume":"267","author":"Lee","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.M507528200_bib33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1107\/S0021889803001997","volume":"36","author":"Walter","year":"2003","journal-title":"J. Appl. Crystallogr."},{"key":"10.1074\/jbc.M507528200_bib34","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1107\/S0909049505009131","volume":"12","author":"Cianci","year":"2005","journal-title":"J. Synchrotron Radiat."},{"key":"10.1074\/jbc.M507528200_bib35","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","volume":"50","author":"Project","year":"1994","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M507528200_bib36","volume":"26","author":"Leslie","year":"1992","journal-title":"Joint CCP4 and ESF-EAMCB Newsletter on Protein Crystallography"},{"key":"10.1074\/jbc.M507528200_bib37","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M507528200_bib38","series-title":"XPREP: Data Preparation and Reciprocal Space Exploration, Version 6.14\/UNIX","author":"Bruker","year":"2003"},{"key":"10.1074\/jbc.M507528200_bib39","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0076-6879(97)77018-6","volume":"277","author":"Sheldrick","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M507528200_bib40","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0076-6879(97)76073-7","volume":"276","author":"delaFortelle","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M507528200_bib41","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1107\/S0907444900005072","volume":"56","author":"Terwilliger","year":"2000","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M507528200_bib42","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M507528200_bib43","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","volume":"53","author":"Murshudov","year":"1997","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1074\/jbc.M507528200_bib44","doi-asserted-by":"crossref","first-page":"5185","DOI":"10.1021\/bi016014e","volume":"41","author":"Elkins","year":"2002","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.M507528200_bib45","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0005-2760(85)90027-X","volume":"835","author":"Muralidharan","year":"1985","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M507528200_bib46","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/72398","volume":"7","author":"Zhang","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"10.1074\/jbc.M507528200_bib47","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0969-2126(01)00695-5","volume":"10","author":"Wilmouth","year":"2002","journal-title":"Structure"},{"key":"10.1074\/jbc.M507528200_bib48","doi-asserted-by":"crossref","first-page":"6625","DOI":"10.1046\/j.0014-2956.2001.02617.x","volume":"268","author":"Clifton","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.M507528200_bib49","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1110\/ps.4570102","volume":"11","author":"Chance","year":"2002","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.M507528200_bib50","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0014-5793(02)02520-6","volume":"517","author":"Zhang","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M507528200_bib51","doi-asserted-by":"crossref","first-page":"7388","DOI":"10.1021\/ja004025+","volume":"123","author":"Zhou","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M507528200_bib52","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M507528200_bib53","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S1074-5521(03)00069-3","volume":"10","author":"N\u0101u\u00e4nez","year":"2003","journal-title":"Chem. Biol."},{"key":"10.1074\/jbc.M507528200_bib54","doi-asserted-by":"crossref","first-page":"6730","DOI":"10.1074\/jbc.M311824200","volume":"279","author":"Sleeman","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M507528200_bib55","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0009-8981(97)00259-3","volume":"271","author":"Jansen","year":"1998","journal-title":"Clin. Chim. Acta."},{"key":"10.1074\/jbc.M507528200_bib56","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1006\/jmbi.2001.4649","volume":"308","author":"Lee","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M507528200_bib57","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1042\/BJ20040735","volume":"383","author":"Lancaster","year":"2004","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M507528200_bib58","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1093\/hmg\/9.8.1195","volume":"9","author":"Jansen","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.M507528200_bib59","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1146\/annurev.cellbio.17.1.701","volume":"17","author":"Perdue","year":"2001","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1074\/jbc.M507528200_bib60","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1039\/b101039p","volume":"11","author":"Mukherji","year":"2001","journal-title":"Chem. Commun."},{"key":"10.1074\/jbc.M507528200_bib61","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1101\/gad.12.8.1189","volume":"12","author":"Seedorf","year":"1998","journal-title":"Gen. Dev."},{"key":"10.1074\/jbc.M507528200_bib62","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1388-1981(00)00047-0","volume":"1486","author":"Seedorf","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M507528200_bib63","doi-asserted-by":"crossref","first-page":"7179","DOI":"10.1093\/emboj\/17.24.7179","volume":"17","author":"Wouters","year":"1998","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M507528200_bib64","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S1359-6446(04)03202-7","volume":"9","author":"Hewitson","year":"2004","journal-title":"Drug Discov. Today"},{"key":"10.1074\/jbc.M507528200_bib65","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1016\/S0960-894X(03)00539-0","volume":"13","author":"Mole","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1074\/jbc.M507528200_bib66","doi-asserted-by":"crossref","first-page":"7680","DOI":"10.1021\/ja050841b","volume":"127","author":"McDonough","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.M507528200_bib67","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1388-1981(03)00003-9","volume":"1631","author":"Wanders","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.M507528200_bib68","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1194\/jlr.M400510-JLR200","volume":"46","author":"Sanders","year":"2005","journal-title":"J. Lipid Res."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820590819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820590819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M507528200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T04:29:06Z","timestamp":1641356946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820590819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":68,"journal-issue":{"issue":"49","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S0021925820590819"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m507528200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}