{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:37:31Z","timestamp":1770503851763,"version":"3.49.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"45","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":5083,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1074\/jbc.m606023200","type":"journal-article","created":{"date-parts":[[2006,8,17]],"date-time":"2006-08-17T00:34:09Z","timestamp":1155774849000},"page":"33900-33909","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["DNA-PKcs Dependence of Artemis Endonucleolytic Activity, Differences between Hairpins and 5\u2032 or 3\u2032 Overhangs"],"prefix":"10.1016","volume":"281","author":[{"given":"Doris","family":"Niewolik","sequence":"first","affiliation":[]},{"given":"Ulrich","family":"Pannicke","sequence":"additional","affiliation":[]},{"given":"Haihui","family":"Lu","sequence":"additional","affiliation":[]},{"given":"Yunmei","family":"Ma","sequence":"additional","affiliation":[]},{"given":"Ling-Chi Vicky","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Kulesza","sequence":"additional","affiliation":[]},{"given":"Ebrahim","family":"Zandi","sequence":"additional","affiliation":[]},{"given":"Michael R.","family":"Lieber","sequence":"additional","affiliation":[]},{"given":"Klaus","family":"Schwarz","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1074\/jbc.M606023200_bib1","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/S0092-8674(02)00675-X","volume":"109","author":"Bassing","year":"2002","journal-title":"Cell"},{"key":"10.1074\/jbc.M606023200_bib2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1146\/annurev.biochem.71.090501.150203","volume":"71","author":"Gellert","year":"2002","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M606023200_bib3","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/bies.10344","volume":"25","author":"Schwarz","year":"2003","journal-title":"BioEssays"},{"key":"10.1074\/jbc.M606023200_bib4","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1146\/annurev.immunol.18.1.495","volume":"18","author":"Fugmann","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1074\/jbc.M606023200_bib5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0092-8674(04)00039-X","volume":"116","author":"Jung","year":"2004","journal-title":"Cell"},{"key":"10.1074\/jbc.M606023200_bib6","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.dnarep.2004.03.015","volume":"3","author":"Lieber","year":"2004","journal-title":"DNA Repair"},{"key":"10.1074\/jbc.M606023200_bib7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.0105-2896.2004.00165.x","volume":"200","author":"Rooney","year":"2004","journal-title":"Immunol. Rev."},{"key":"10.1074\/jbc.M606023200_bib8","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cell.2005.12.030","volume":"124","author":"Buck","year":"2006","journal-title":"Cell"},{"key":"10.1074\/jbc.M606023200_bib9","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cell.2005.12.031","volume":"124","author":"Ahnesorg","year":"2006","journal-title":"Cell"},{"key":"10.1074\/jbc.M606023200_bib10","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.1182\/blood-2004-12-4861","volume":"105","author":"Ege","year":"2005","journal-title":"Blood"},{"key":"10.1074\/jbc.M606023200_bib11","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S1097-2765(01)00408-7","volume":"8","author":"O'Driscoll","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M606023200_bib12","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0092-8674(00)81448-8","volume":"93","author":"Villa","year":"1998","journal-title":"Cell"},{"key":"10.1074\/jbc.M606023200_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1182\/blood.V97.1.81","volume":"97","author":"Villa","year":"2001","journal-title":"Blood"},{"key":"10.1074\/jbc.M606023200_bib14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0092-8674(01)00309-9","volume":"105","author":"Moshous","year":"2001","journal-title":"Cell"},{"key":"10.1074\/jbc.M606023200_bib15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1172\/JCI16774","volume":"111","author":"Moshous","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M606023200_bib16","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1182\/blood-2002-01-0187","volume":"101","author":"Noordzij","year":"2003","journal-title":"Blood"},{"key":"10.1074\/jbc.M606023200_bib17","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/eji.200535401","volume":"36","author":"Buck","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1074\/jbc.M606023200_bib18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1172\/JCI26121","volume":"116","author":"van der Burg","year":"2006","journal-title":"J. Clin. Investig."},{"key":"10.1074\/jbc.M606023200_bib19","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0092-8674(02)00671-2","volume":"108","author":"Ma","year":"2002","journal-title":"Cell"},{"key":"10.1074\/jbc.M606023200_bib20","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.dnarep.2005.04.013","volume":"4","author":"Ma","year":"2005","journal-title":"DNA Repair"},{"key":"10.1074\/jbc.M606023200_bib21","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.molcel.2004.10.029","volume":"16","author":"Riballo","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M606023200_bib22","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1093\/nar\/gkf470","volume":"30","author":"Callebaut","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M606023200_bib23","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1038\/sj.emboj.7600206","volume":"23","author":"Pannicke","year":"2004","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M606023200_bib24","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1084\/jem.20031142","volume":"199","author":"Poinsignon","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.M606023200_bib25","doi-asserted-by":"crossref","first-page":"33839","DOI":"10.1074\/jbc.M507113200","volume":"280","author":"Ma","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M606023200_bib26","series-title":"DNA-dependent Protein Kinase in V(D)J Recombination: Reconstitution of the SCID Defect by Human DNA-PKc DNA","author":"Kulesza","year":"1999"},{"key":"10.1074\/jbc.M606023200_bib27","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0092-8674(79)90093-X","volume":"16","author":"Wigler","year":"1979","journal-title":"Cell"},{"key":"10.1074\/jbc.M606023200_bib28","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0076-6879(06)08031-1","volume":"408","author":"Ma","year":"2006","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.M606023200_bib29","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.cellbio.18.031502.133614","volume":"18","author":"Pufall","year":"2002","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1074\/jbc.M606023200_bib30","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S1097-2765(00)80066-0","volume":"1","author":"Zhong","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M606023200_bib31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0092-8674(93)90057-W","volume":"72","author":"Gottlieb","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.M606023200_bib32","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.jmb.2006.02.061","volume":"358","author":"Soubeyrand","year":"2006","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.M606023200_bib33","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S1568-7864(03)00143-5","volume":"2","author":"Yu","year":"2003","journal-title":"DNA Repair"},{"key":"10.1074\/jbc.M606023200_bib34","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.dnarep.2003.11.005","volume":"3","author":"Lee","year":"2004","journal-title":"DNA Repair"},{"key":"10.1074\/jbc.M606023200_bib35","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1093\/nar\/27.17.3494","volume":"27","author":"Gell","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M606023200_bib36","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1128\/MCB.19.5.3267","volume":"19","author":"Singleton","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M606023200_bib37","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nature03442","volume":"434","author":"Falck","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M606023200_bib38","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1074\/jbc.275.3.1541","volume":"275","author":"Hammarsten","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M606023200_bib39","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1042\/bj20020973","volume":"368","author":"Douglas","year":"2002","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.M606023200_bib40","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.1128\/MCB.23.16.5836-5848.2003","volume":"23","author":"Ding","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M606023200_bib41","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1093\/nar\/gkh761","volume":"32","author":"Block","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.M606023200_bib42","doi-asserted-by":"crossref","first-page":"10842","DOI":"10.1128\/MCB.25.24.10842-10852.2005","volume":"25","author":"Cui","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.M606023200_bib43","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.dnarep.2005.05.003","volume":"4","author":"Douglas","year":"2005","journal-title":"DNA Repair"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820705752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925820705752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M606023200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T07:49:16Z","timestamp":1723535356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925820705752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":43,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0021925820705752"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m606023200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA-PKcs Dependence of Artemis Endonucleolytic Activity, Differences between Hairpins and 5\u2032 or 3\u2032 Overhangs","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.M606023200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2006 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}