{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:12:11Z","timestamp":1768907531870,"version":"3.49.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":4931,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1074\/jbc.m610106200","type":"journal-article","created":{"date-parts":[[2007,1,26]],"date-time":"2007-01-26T01:11:40Z","timestamp":1169773900000},"page":"11836-11848","source":"Crossref","is-referenced-by-count":47,"title":["p21-activated Kinase 1 Is Activated through the Mammalian Target of Rapamycin\/p70 S6 Kinase Pathway and Regulates the Replication of Hepatitis C Virus in Human Hepatoma Cells"],"prefix":"10.1016","volume":"282","author":[{"given":"Hisashi","family":"Ishida","sequence":"first","affiliation":[]},{"given":"Kui","family":"Li","sequence":"additional","affiliation":[]},{"given":"MinKyung","family":"Yi","sequence":"additional","affiliation":[]},{"given":"Stanley M.","family":"Lemon","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1074\/jbc.M610106200_bib1","doi-asserted-by":"crossref","first-page":"21S","DOI":"10.1002\/hep.510260704","volume":"26","author":"Seeff","year":"1997","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M610106200_bib2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1056\/NEJM200107053450107","volume":"345","author":"Lauer","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1074\/jbc.M610106200_bib3","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1073\/pnas.88.6.2451","volume":"88","author":"Choo","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M610106200_bib4","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1002\/hep.510250637","volume":"25","author":"Major","year":"1997","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M610106200_bib5","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1128\/JVI.79.9.5241-5248.2005","volume":"79","author":"Conzelmann","year":"2005","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M610106200_bib6","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.1082604","volume":"300","author":"Foy","year":"2003","journal-title":"Science"},{"key":"10.1074\/jbc.M610106200_bib7","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1073\/pnas.0408824102","volume":"102","author":"Li","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M610106200_bib8","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/nature04193","volume":"437","author":"Meylan","year":"2005","journal-title":"Nature"},{"key":"10.1074\/jbc.M610106200_bib9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1126\/science.285.5424.110","volume":"285","author":"Lohmann","year":"1999","journal-title":"Science"},{"key":"10.1074\/jbc.M610106200_bib10","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nm1268","volume":"11","author":"Wakita","year":"2005","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.M610106200_bib11","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1073\/pnas.0510727103","volume":"103","author":"Yi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M610106200_bib12","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1126\/science.1114016","volume":"309","author":"Lindenbach","year":"2005","journal-title":"Science"},{"key":"10.1074\/jbc.M610106200_bib13","doi-asserted-by":"crossref","first-page":"9294","DOI":"10.1073\/pnas.0503596102","volume":"102","author":"Zhong","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M610106200_bib14","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1099\/0022-1317-82-4-723","volume":"82","author":"Frese","year":"2001","journal-title":"J. Gen. Virol."},{"key":"10.1074\/jbc.M610106200_bib15","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1053\/jhep.2002.31770","volume":"35","author":"Frese","year":"2002","journal-title":"Hepatology"},{"key":"10.1074\/jbc.M610106200_bib16","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1128\/JVI.77.9.5493-5498.2003","volume":"77","author":"Zhu","year":"2003","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M610106200_bib17","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.virol.2004.10.036","volume":"331","author":"Murata","year":"2005","journal-title":"Virology"},{"key":"10.1074\/jbc.M610106200_bib18","doi-asserted-by":"crossref","first-page":"20374","DOI":"10.1074\/jbc.M210785200","volume":"278","author":"Pause","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M610106200_bib19","doi-asserted-by":"crossref","first-page":"38322","DOI":"10.1074\/jbc.M205566200","volume":"277","author":"Dhanak","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M610106200_bib20","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1073\/pnas.0235524100","volume":"100","author":"Randall","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M610106200_bib21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.virol.2005.06.015","volume":"340","author":"Murata","year":"2005","journal-title":"Virology"},{"key":"10.1074\/jbc.M610106200_bib22","doi-asserted-by":"crossref","first-page":"8742","DOI":"10.1128\/JVI.79.14.8742-8749.2005","volume":"79","author":"Mannova","year":"2005","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M610106200_bib23","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1128\/JVI.78.3.1513-1524.2004","volume":"78","author":"Scholle","year":"2004","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M610106200_bib24","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1128\/JVI.75.3.1252-1264.2001","volume":"75","author":"Pietschmann","year":"2001","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M610106200_bib25","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1146\/annurev.biochem.72.121801.161742","volume":"72","author":"Bokoch","year":"2003","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.M610106200_bib26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1097-2765(01)00428-2","volume":"9","author":"Parrini","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1074\/jbc.M610106200_bib27","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.febslet.2004.04.069","volume":"567","author":"Ehrhardt","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.M610106200_bib28","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1128\/JVI.76.6.2997-3006.2002","volume":"76","author":"Ikeda","year":"2002","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M610106200_bib29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1089\/088282402317340215","volume":"15","author":"Fredericksen","year":"2003","journal-title":"Viral Immunol."},{"key":"10.1074\/jbc.M610106200_bib30","doi-asserted-by":"crossref","first-page":"11347","DOI":"10.1128\/JVI.74.23.11347-11358.2000","volume":"74","author":"Wang","year":"2000","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M610106200_bib31","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1128\/JVI.01890-06","volume":"81","author":"Yi","year":"2007","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M610106200_bib32","doi-asserted-by":"crossref","first-page":"16739","DOI":"10.1074\/jbc.M414139200","volume":"280","author":"Li","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M610106200_bib33","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1128\/JVI.79.5.2689-2699.2005","volume":"79","author":"Sumpter","year":"2005","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M610106200_bib34","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0898-6568(03)00087-1","volume":"15","author":"Menard","year":"2003","journal-title":"Cell. Signal."},{"key":"10.1074\/jbc.M610106200_bib35","doi-asserted-by":"crossref","first-page":"19693","DOI":"10.1074\/jbc.M909860199","volume":"275","author":"Frost","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M610106200_bib36","doi-asserted-by":"crossref","first-page":"6426","DOI":"10.1093\/emboj\/16.21.6426","volume":"16","author":"Frost","year":"1997","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M610106200_bib37","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1074\/jbc.M309937200","volume":"279","author":"Balasenthil","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M610106200_bib38","doi-asserted-by":"crossref","first-page":"23934","DOI":"10.1074\/jbc.270.41.23934","volume":"270","author":"Zhang","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M610106200_bib39","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/S0960-9822(02)00546-8","volume":"6","author":"Brown","year":"1996","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.M610106200_bib40","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","volume":"18","author":"Hay","year":"2004","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M610106200_bib41","doi-asserted-by":"crossref","first-page":"13038","DOI":"10.1073\/pnas.0405152101","volume":"101","author":"Evans","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M610106200_bib42","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1126\/science.290.5498.1972","volume":"290","author":"Blight","year":"2000","journal-title":"Science"},{"key":"10.1074\/jbc.M610106200_bib43","doi-asserted-by":"crossref","first-page":"13306","DOI":"10.1128\/JVI.78.23.13306-13314.2004","volume":"78","author":"Neddermann","year":"2004","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M610106200_bib44","doi-asserted-by":"crossref","first-page":"11305","DOI":"10.1128\/JVI.01465-06","volume":"80","author":"Quintavalle","year":"2006","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M610106200_bib45","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/377441a0","volume":"377","author":"Brown","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.M610106200_bib46","doi-asserted-by":"crossref","first-page":"26457","DOI":"10.1074\/jbc.272.42.26457","volume":"272","author":"Hara","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M610106200_bib47","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1002\/j.1460-2075.1995.tb00257.x","volume":"14","author":"Haghighat","year":"1995","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M610106200_bib48","doi-asserted-by":"crossref","first-page":"5256","DOI":"10.1002\/j.1460-2075.1996.tb00911.x","volume":"15","author":"Brunn","year":"1996","journal-title":"EMBO J."},{"key":"10.1074\/jbc.M610106200_bib49","doi-asserted-by":"crossref","first-page":"6668","DOI":"10.4049\/jimmunol.169.12.6668","volume":"169","author":"Yamamoto","year":"2002","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.M610106200_bib50","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1073\/pnas.0601523103","volume":"103","author":"Loo","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.M610106200_bib51","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1128\/JVI.80.1.226-235.2006","volume":"80","author":"Noyce","year":"2006","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M610106200_bib52","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1128\/JVI.80.9.4510-4520.2006","volume":"80","author":"Ishii","year":"2006","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M610106200_bib53","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb839","volume":"4","author":"Inoki","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/jbc.M610106200_bib54","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cell.2005.02.031","volume":"121","author":"Ma","year":"2005","journal-title":"Cell"},{"key":"10.1074\/jbc.M610106200_bib55","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1101\/gad.887201","volume":"15","author":"Gingras","year":"2001","journal-title":"Genes Dev."},{"key":"10.1074\/jbc.M610106200_bib56","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cellsig.2006.05.029","volume":"19","author":"Sharrard","year":"2007","journal-title":"Cell. Signal."},{"key":"10.1074\/jbc.M610106200_bib57","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1128\/JVI.78.7.3502-3513.2004","volume":"78","author":"Coito","year":"2004","journal-title":"J. Virol."},{"key":"10.1074\/jbc.M610106200_bib58","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1074\/jbc.274.2.687","volume":"274","author":"Westphal","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M610106200_bib59","doi-asserted-by":"crossref","first-page":"6196","DOI":"10.1074\/jbc.M307261200","volume":"279","author":"Wittmann","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.M610106200_bib60","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1128\/JVI.77.7.4401-4408.2003","volume":"77","author":"Bost","year":"2003","journal-title":"J. Virol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819581650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819581650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.M610106200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T06:26:01Z","timestamp":1625811961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819581650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":60,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0021925819581650"],"URL":"https:\/\/doi.org\/10.1074\/jbc.m610106200","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}