{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T05:51:29Z","timestamp":1769579489362,"version":"3.49.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":6452,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular &amp; Cellular Proteomics"],"published-print":{"date-parts":[[2003,2]]},"DOI":"10.1074\/mcp.m200074-mcp200","type":"journal-article","created":{"date-parts":[[2003,4,2]],"date-time":"2003-04-02T16:49:56Z","timestamp":1049302196000},"page":"96-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":137,"title":["PRISM, a Generic Large Scale Proteomic Investigation Strategy for Mammals*S"],"prefix":"10.1016","volume":"2","author":[{"given":"Thomas","family":"Kislinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Radulovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Rossant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Emili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M200074-MCP200_bib1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S1471-4914(01)02164-5","article-title":"Mouse-based phenogenomics for modelling human disease","volume":"7","author":"Rossant","year":"2001","journal-title":"Trends Mol. Med."},{"key":"10.1074\/mcp.M200074-MCP200_bib2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1126\/science.1058244","article-title":"Sequence interpretation. Functional annotation of mouse genome sequences","volume":"291","author":"Nadeau","year":"2001","journal-title":"Science."},{"key":"10.1074\/mcp.M200074-MCP200_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/5976","article-title":"An encyclopedia of mouse genes","volume":"21","author":"Marra","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1074\/mcp.M200074-MCP200_bib4","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nature01266","article-title":"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs","volume":"420","author":"Okazaki","year":"2002","journal-title":"Nature."},{"key":"10.1074\/mcp.M200074-MCP200_bib5","doi-asserted-by":"crossref","first-page":"E190","DOI":"10.1038\/35087138","article-title":"Navigating gene expression using microarrays\u2014a technology review","volume":"3","author":"Schulze","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1074\/mcp.M200074-MCP200_bib6","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1128\/MCB.19.3.1720","article-title":"Correlation between protein and mRNA abundance in yeast","volume":"19","author":"Gygi","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/mcp.M200074-MCP200_bib7","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/(SICI)1522-2683(20000401)21:6<1202::AID-ELPS1202>3.0.CO;2-I","article-title":"Biomedical applications of two-dimensional electrophoresis using immobilized pH gradients: current status","volume":"21","author":"Hanash","year":"2000","journal-title":"Electrophoresis."},{"key":"10.1074\/mcp.M200074-MCP200_bib8","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1002\/1522-2683(200108)22:14<2865::AID-ELPS2865>3.0.CO;2-Y","article-title":"Zooming-in on the proteome: very narrow-range immobilised pH gradients reveal more protein species and isoforms","volume":"22","author":"Westbrook","year":"2001","journal-title":"Electrophoresis."},{"key":"10.1074\/mcp.M200074-MCP200_bib9","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1002\/(SICI)1522-2683(20000401)21:6<1104::AID-ELPS1104>3.0.CO;2-C","article-title":"The dynamic range of protein expression: a challenge for proteomic research","volume":"21","author":"Corthals","year":"2000","journal-title":"Electrophoresis."},{"key":"10.1074\/mcp.M200074-MCP200_bib10","doi-asserted-by":"crossref","first-page":"9390","DOI":"10.1073\/pnas.160270797","article-title":"Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology","volume":"97","author":"Gygi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/mcp.M200074-MCP200_bib11","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/10890","article-title":"Direct analysis of protein complexes using mass spectrometry","volume":"17","author":"Link","year":"1999","journal-title":"Nat. Biotechnol."},{"key":"10.1074\/mcp.M200074-MCP200_bib12","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/85686","article-title":"Large-scale analysis of the yeast proteome by multidimensional protein identification technology","volume":"19","author":"Washburn","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"10.1074\/mcp.M200074-MCP200_bib13","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1021\/ac010617e","article-title":"An automated multidimensional protein identification technology for shotgun proteomics","volume":"73","author":"Wolters","year":"2001","journal-title":"Anal. Chem."},{"key":"10.1074\/mcp.M200074-MCP200_bib14","doi-asserted-by":"crossref","first-page":"11969","DOI":"10.1073\/pnas.172183199","article-title":"Proteomic survey of metabolic pathways in rice","volume":"99","author":"Koller","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/mcp.M200074-MCP200_bib15","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature01107","article-title":"A proteomic view of the Plasmodium falciparum life cycle","volume":"419","author":"Florens","year":"2002","journal-title":"Nature."},{"key":"10.1074\/mcp.M200074-MCP200_bib16","doi-asserted-by":"crossref","first-page":"11049","DOI":"10.1073\/pnas.172170199","article-title":"Global analysis of the Deinococcus radiodurans proteome by using accurate mass tags","volume":"99","author":"Lipton","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/mcp.M200074-MCP200_bib17","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nbt1001-946","article-title":"Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry","volume":"19","author":"Han","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"10.1074\/mcp.M200074-MCP200_bib18","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nature01111","article-title":"Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry","volume":"419","author":"Lasonder","year":"2002","journal-title":"Nature."},{"key":"10.1074\/mcp.M200074-MCP200_bib19","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature01262","article-title":"Initial sequencing and comparative analysis of the mouse genome","volume":"420","author":"Waterston","year":"2002","journal-title":"Nature."},{"key":"10.1074\/mcp.M200074-MCP200_bib20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1074\/mcp.M200074-MCP200_bib21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nbt0202-163","article-title":"De novo peptide sequencing and quantitative profiling of complex protein mixtures using mass-coded abundance tagging","volume":"20","author":"Cagney","year":"2002","journal-title":"Nat. Biotechnol."},{"key":"10.1074\/mcp.M200074-MCP200_bib22","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S1044-0305(02)00352-5","article-title":"Qscore: an algorithm for evaluating SEQUEST database search results","volume":"13","author":"Moore","year":"2002","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1074\/mcp.M200074-MCP200_bib23","series-title":"Statistical Inference","author":"Casella","year":"1990"},{"key":"10.1074\/mcp.M200074-MCP200_bib24","unstructured":"Radulovic, D., and Appel, M. (2000) Accelerated random search, in Proceedings of 16th IMACS World Congress on Scientific Computing, Laussanne, Switzerland, August 21\u201325, 2000"},{"key":"10.1074\/mcp.M200074-MCP200_bib25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1021\/pr015504q","article-title":"DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics","volume":"1","author":"Tabb","year":"2002","journal-title":"J. Proteome Res."},{"key":"10.1074\/mcp.M200074-MCP200_bib26","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1101\/gr.473902","article-title":"Large-scale proteomic analysis of the human spliceosome","volume":"12","author":"Rappsilber","year":"2002","journal-title":"Genome Res."},{"key":"10.1074\/mcp.M200074-MCP200_bib27","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1083\/jcb.200206106","article-title":"Proteomic analysis of the mammalian nuclear pore complex","volume":"158","author":"Cronshaw","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1074\/mcp.M200074-MCP200_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0960-9822(01)00650-9","article-title":"Directed proteomic analysis of the human nucleolus","volume":"12","author":"Andersen","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1074\/mcp.M200074-MCP200_bib29","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1091\/mbc.e02-05-0271","article-title":"Functional proteomic analysis of human nucleolus","volume":"13","author":"Scherl","year":"2002","journal-title":"Mol. Biol. Cell."},{"key":"10.1074\/mcp.M200074-MCP200_bib30","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/1044-0305(94)80016-2","article-title":"An approach to correlate tandem mass-spectral data of peptides with amino-acid-sequences in a protein database","volume":"11","author":"Eng","year":"1994","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1074\/mcp.M200074-MCP200_bib31","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1021\/ac00104a020","article-title":"Method to correlate tandem mass spectra of modified peptides to amino acid sequences in the protein database","volume":"67","author":"Yates","year":"1995","journal-title":"Anal. Chem."},{"key":"10.1074\/mcp.M200074-MCP200_bib32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/nar\/28.1.45","article-title":"The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000","volume":"28","author":"Bairoch","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/mcp.M200074-MCP200_bib33","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/nar\/30.1.38","article-title":"The Ensembl genome database project","volume":"30","author":"Hubbard","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/mcp.M200074-MCP200_bib34","doi-asserted-by":"crossref","first-page":"14863","DOI":"10.1073\/pnas.95.25.14863","article-title":"Cluster analysis and display of genome-wide expression patterns","volume":"95","author":"Eisen","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/mcp.M200074-MCP200_bib35","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1055\/s-2008-1040480","article-title":"Role of cytochromes P450 in drug metabolism and hepatotoxicity","volume":"10","author":"Watkins","year":"1990","journal-title":"Semin. Liver Dis."},{"key":"10.1074\/mcp.M200074-MCP200_bib36","doi-asserted-by":"crossref","first-page":"11430","DOI":"10.1021\/bi00112a009","article-title":"Mouse pulmonary cytochrome P-450 naphthalene hydroxylase: cDNA cloning, sequence, and expression in Saccharomyces cerevisiae","volume":"30","author":"Ritter","year":"1991","journal-title":"Biochemistry."},{"key":"10.1074\/mcp.M200074-MCP200_bib37","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/abbi.1995.1393","article-title":"Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal cytochrome P450 CYP4B1: cloning and characterization of mouse CYP4B1","volume":"321","author":"Imaoka","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/mcp.M200074-MCP200_bib38","first-page":"L546","article-title":"Murine pulmonary surfactant SP-A gene: cloning, sequence, and transcriptional activity","volume":"263","author":"Korfhagen","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1074\/mcp.M200074-MCP200_bib39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0167-4781(94)00177-5","article-title":"Identification of two splice isoforms of mRNA for mouse hepatocyte nuclear factor 4 (HNF-4)","volume":"1260","author":"Hata","year":"1995","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1074\/mcp.M200074-MCP200_bib40","first-page":"1415","article-title":"Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and \u03b11-antitrypsin genes","volume":"9","author":"Costa","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/mcp.M200074-MCP200_bib41","doi-asserted-by":"crossref","first-page":"9013","DOI":"10.1074\/jbc.274.13.9013","article-title":"CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression","volume":"274","author":"Dell","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1074\/mcp.M200074-MCP200_bib42","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1006\/dbio.1997.8744","article-title":"The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 \u03b2 in the developing murine liver and pancreas","volume":"192","author":"Rausa","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1074\/mcp.M200074-MCP200_bib43","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/35055500","article-title":"Functional annotation of a full-length mouse cDNA collection","volume":"409","author":"Kawai","year":"2001","journal-title":"Nature."},{"key":"10.1074\/mcp.M200074-MCP200_bib44","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1006\/bbrc.1999.1887","article-title":"Forty years of cytochrome P450","volume":"266","author":"Omura","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/mcp.M200074-MCP200_bib45","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1177\/00912700122012724","article-title":"Human drug metabolism and the cytochromes P450: application and relevance of in vitro models","volume":"41","author":"Venkatakrishnan","year":"2001","journal-title":"J. Clin. Pharmacol."},{"key":"10.1074\/mcp.M200074-MCP200_bib46","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2174\/1389200023337054","article-title":"The cytochrome p450 superfamily: biochemistry, evolution and drug metabolism in humans","volume":"3","author":"Danielson","year":"2002","journal-title":"Curr. Drug Metab."},{"key":"10.1074\/mcp.M200074-MCP200_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-022X(00)00066-X","article-title":"Fractionation of cells and subcellular particles with Percoll","volume":"44","author":"Pertoft","year":"2000","journal-title":"J. Biochem. Biophys. Methods."},{"key":"10.1074\/mcp.M200074-MCP200_bib48","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1021\/ac025747h","article-title":"Empirical statistical model to estimate the accuracy of peptide identifications made by MS\/MS and database search","volume":"74","author":"Keller","year":"2002","journal-title":"Anal. Chem."},{"key":"10.1074\/mcp.M200074-MCP200_bib49","doi-asserted-by":"crossref","first-page":"6591","DOI":"10.1073\/pnas.96.12.6591","article-title":"Accurate quantitation of protein expression and site-specific phosphorylation","volume":"96","author":"Oda","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/mcp.M200074-MCP200_bib50","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/1522-2683(200105)22:9<1652::AID-ELPS1652>3.0.CO;2-E","article-title":"Rapid quantitative measurements of proteomes by Fourier transform ion cyclotron resonance mass spectrometry","volume":"22","author":"Smith","year":"2001","journal-title":"Electrophoresis."},{"key":"10.1074\/mcp.M200074-MCP200_bib51","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/1615-9861(200205)2:5<513::AID-PROT513>3.0.CO;2-W","article-title":"An accurate mass tag strategy for quantitative and high-throughput proteome measurements","volume":"2","author":"Smith","year":"2002","journal-title":"Proteomics."},{"key":"10.1074\/mcp.M200074-MCP200_bib52","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/13690","article-title":"Quantitative analysis of complex protein mixtures using isotope-coded affinity tags","volume":"17","author":"Gygi","year":"1999","journal-title":"Nat. Biotechnol."}],"container-title":["Molecular &amp; Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620341165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620341165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M200074-MCP200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:56:21Z","timestamp":1761526581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620341165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["S1535947620341165"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m200074-mcp200","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2003,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PRISM, a Generic Large Scale Proteomic Investigation Strategy for Mammals","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M200074-MCP200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2003 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}