{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:33:22Z","timestamp":1768822402766,"version":"3.49.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":4347,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["mcponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular & Cellular Proteomics"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1074\/mcp.m800218-mcp200","type":"journal-article","created":{"date-parts":[[2008,6,5]],"date-time":"2008-06-05T20:13:42Z","timestamp":1212696822000},"page":"1952-1962","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":143,"title":["Accurate Inclusion Mass Screening"],"prefix":"10.1016","volume":"7","author":[{"given":"Jacob D.","family":"Jaffe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasmik","family":"Keshishian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa A.","family":"Addona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Gillette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven A.","family":"Carr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/mcp.M800218-MCP200_bib1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nrc1041","article-title":"The case for early detection","volume":"3","author":"Etzioni","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/mcp.M800218-MCP200_bib2","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1074\/mcp.R200007-MCP200","article-title":"The human plasma proteome: history, character, and diagnostic prospects","volume":"1","author":"Anderson","year":"2002","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M800218-MCP200_bib3","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1074\/mcp.I500001-MCP200","article-title":"The roles of multiple proteomic platforms in a pipeline for new diagnostics","volume":"4","author":"Anderson","year":"2005","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M800218-MCP200_bib4","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrc1911","article-title":"The US Food and Drug Administration perspective on cancer biomarker development","volume":"6","author":"Gutman","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1074\/mcp.M800218-MCP200_bib5","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nbt1235","article-title":"Protein biomarker discovery and validation: the long and uncertain path to clinical utility","volume":"24","author":"Rifai","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"10.1074\/mcp.M800218-MCP200_bib6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1021\/pr0703223","article-title":"A proteome resource of ovarian cancer ascites: integrated proteomic and bioinformatic analyses to identify putative biomarkers","volume":"7","author":"Gortzak-Uzan","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1074\/mcp.M800218-MCP200_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/prca.200780174","article-title":"The interface between biomarker discovery and clinical validation: the tar pit of the protein biomarker pipeline","author":"Paulovich","year":"2008","journal-title":"Proteomics Clin. Appl."},{"key":"10.1074\/mcp.M800218-MCP200_bib8","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1074\/mcp.M700354-MCP200","article-title":"Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution","volume":"6","author":"Keshishian","year":"2007","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M800218-MCP200_bib9","doi-asserted-by":"crossref","first-page":"3962","DOI":"10.1021\/pr070202v","article-title":"Integrated pipeline for mass spectrometry-based discovery and confirmation of biomarkers demonstrated in a mouse model of breast cancer","volume":"6","author":"Whiteaker","year":"2007","journal-title":"J. Proteome Res."},{"key":"10.1074\/mcp.M800218-MCP200_bib10","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/ng1776","article-title":"Systematic identification of human mitochondrial disease genes through integrative genomics","volume":"38","author":"Calvo","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1074\/mcp.M800218-MCP200_bib11","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1074\/mcp.M600222-MCP200","article-title":"PEPPeR, a platform for experimental proteomic pattern recognition","volume":"5","author":"Jaffe","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M800218-MCP200_bib12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1021\/pr034086h","article-title":"Mass spectrometric quantitation of peptides and proteins using Stable Isotope Standards and Capture by Anti-Peptide Antibodies (SISCAPA)","volume":"3","author":"Anderson","year":"2004","journal-title":"J. Proteome Res."},{"key":"10.1074\/mcp.M800218-MCP200_bib13","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1021\/ac702311m","article-title":"Quantification of NTproBNP in rat serum using immunoprecipitation and LC\/MS\/MS: a biomarker of drug-induced cardiac hypertrophy","volume":"80","author":"Berna","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1074\/mcp.M800218-MCP200_bib14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ab.2006.12.023","article-title":"Antibody-based enrichment of peptides on magnetic beads for mass-spectrometry-based quantification of serum biomarkers","volume":"362","author":"Whiteaker","year":"2007","journal-title":"Anal. Biochem."},{"key":"10.1074\/mcp.M800218-MCP200_bib15","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1074\/mcp.M700029-MCP200","article-title":"The implications of proteolytic background for shotgun proteomics","volume":"6","author":"Picotti","year":"2007","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1074\/mcp.M800218-MCP200_bib16","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1074\/mcp.M500113-MCP200","article-title":"Multiple reaction monitoring to identify sites of protein phosphorylation with high sensitivity","volume":"4","author":"Unwin","year":"2005","journal-title":"Mol. Cell. Proteomics"}],"container-title":["Molecular & Cellular Proteomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620312780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1535947620312780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/mcp.M800218-MCP200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:25:58Z","timestamp":1761524758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1535947620312780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S1535947620312780"],"URL":"https:\/\/doi.org\/10.1074\/mcp.m800218-mcp200","relation":{},"ISSN":["1535-9476"],"issn-type":[{"value":"1535-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Accurate Inclusion Mass Screening","name":"articletitle","label":"Article Title"},{"value":"Molecular & Cellular Proteomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/mcp.M800218-MCP200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2008 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}