{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:20:10Z","timestamp":1791206410811,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[1995,5,1]],"date-time":"1995-05-01T00:00:00Z","timestamp":799286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":9335,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1995,5]]},"DOI":"10.1074\/jbc.270.19.11463","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:54:25Z","timestamp":1027695265000},"page":"11463-11471","source":"Crossref","is-referenced-by-count":279,"title":["Induction of Interleukin 6 (IL-6) by Hypoxia in Vascular Cells"],"prefix":"10.1016","volume":"270","author":[{"given":"Shi Fang","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Tritto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerold","family":"Brett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lester","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.270.19.11463_bib1","first-page":"H1269","volume":"255","author":"Granger","year":"1988","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.270.19.11463_bib2","series-title":"Pathophysiology of Severe Ischemic Myocardial Injury","first-page":"239","author":"Mullane","year":"1990"},{"key":"10.1074\/jbc.270.19.11463_bib3","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1172\/JCI116122","volume":"90","author":"Shreeniwas","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.270.19.11463_bib4","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1172\/JCI115913","volume":"90","author":"Koga","year":"1992","journal-title":"J. Clin Invest."},{"key":"10.1074\/jbc.270.19.11463_bib5","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1172\/JCI115953","volume":"90","author":"Metinko","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.270.19.11463_bib6","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1172\/JCI117135","volume":"93","author":"Karakurum","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.270.19.11463_bib7","first-page":"426","volume":"133","author":"Pober","year":"1988","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.270.19.11463_bib8","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1172\/JCI114656","volume":"85","author":"Colletti","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.270.19.11463_bib9","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/365654a0","volume":"365","author":"Sekido","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.270.19.11463_bib10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.iy.06.040188.002413","volume":"6","author":"Kishimoto","year":"1988","journal-title":"Annu. Rev. Immunol."},{"key":"10.1074\/jbc.270.19.11463_bib11","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1128\/iai.61.4.1496-1499.1993","volume":"6","author":"Barton","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1074\/jbc.270.19.11463_bib12","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.4049\/jimmunol.143.11.3517","volume":"143","author":"Aderka","year":"1989","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.270.19.11463_bib13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1182\/blood.V75.1.40.40","volume":"75","author":"Schindler","year":"1990","journal-title":"Blood"},{"key":"10.1074\/jbc.270.19.11463_bib14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1182\/blood.V83.1.113.113","volume":"83","author":"Tilg","year":"1994","journal-title":"Blood"},{"key":"10.1074\/jbc.270.19.11463_bib15","first-page":"1097","volume":"138","author":"Ulich","year":"1991","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.270.19.11463_bib16","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/j.1460-2075.1990.tb08316.x","volume":"8","author":"Akira","year":"1990","journal-title":"EMBO J."},{"key":"10.1074\/jbc.270.19.11463_bib17","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/337471a0","volume":"337","author":"Bussolino","year":"1989","journal-title":"Nature"},{"key":"10.1074\/jbc.270.19.11463_bib18","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1182\/blood.V77.8.1675.1675","volume":"77","author":"Yong","year":"1991","journal-title":"Blood"},{"key":"10.1074\/jbc.270.19.11463_bib20","first-page":"517","volume":"27","author":"Colucci","year":"1985","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.270.19.11463_bib21","doi-asserted-by":"crossref","first-page":"6701","DOI":"10.1073\/pnas.85.18.6701","volume":"85","author":"Ray","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.270.19.11463_bib22","first-page":"935","volume":"6","author":"Bartalena","year":"1992","journal-title":"Mol. Endocrinol."},{"key":"10.1074\/jbc.270.19.11463_bib23","first-page":"60","volume":"74","author":"Kasahana","year":"1991","journal-title":"Immunology"},{"key":"10.1074\/jbc.270.19.11463_bib24","first-page":"1699","volume":"143","author":"Brett","year":"1993","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.270.19.11463_bib25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0378-1119(91)90422-8","volume":"101","author":"Grenett","year":"1991","journal-title":"Gene (Amst.)"},{"key":"10.1074\/jbc.270.19.11463_bib26","first-page":"5537","volume":"9","author":"Ray","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.270.19.11463_bib27","first-page":"5736","volume":"10","author":"Ray","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.270.19.11463_bib28","first-page":"347","volume":"8","author":"Hensel","year":"1989","journal-title":"Lymphokine Res."},{"key":"10.1074\/jbc.270.19.11463_bib29","series-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","year":"1989"},{"key":"10.1074\/jbc.270.19.11463_bib30","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/nar\/11.5.1475","volume":"11","author":"Dignam","year":"1983","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.270.19.11463_bib31","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1096\/fasebj.4.11.2199284","volume":"4","author":"Akira","year":"1990","journal-title":"FASEB J."},{"key":"10.1074\/jbc.270.19.11463_bib32","first-page":"5447","volume":"12","author":"Semenza","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.270.19.11463_bib33","first-page":"1935","volume":"11","author":"Anderson","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.270.19.11463_bib34","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1172\/JCI114540","volume":"85","author":"Ogawa","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.270.19.11463_bib35","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1172\/JCI114759","volume":"86","author":"Kourembanas","year":"1991","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.270.19.11463_bib36","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1101\/gad.5.9.1538","volume":"5","author":"Cao","year":"1991","journal-title":"Genes & Dev."},{"key":"10.1074\/jbc.270.19.11463_bib37","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1101\/gad.5.9.1553","volume":"5","author":"William","year":"1991","journal-title":"Genes & Dev."},{"key":"10.1074\/jbc.270.19.11463_bib38","first-page":"H898","volume":"266","author":"Ohkawa","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.270.19.11463_bib39","first-page":"H1713","volume":"260","author":"Ikeda","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.270.19.11463_bib40","first-page":"445","volume":"20","author":"Nabata","year":"1990","journal-title":"Biochem. Int."},{"key":"10.1074\/jbc.270.19.11463_bib41","first-page":"151","volume":"100","author":"Meyrick","year":"1980","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.270.19.11463_bib42","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1126\/science.3603030","volume":"237","author":"Mecham","year":"1987","journal-title":"Science"},{"key":"10.1074\/jbc.270.19.11463_bib43","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/j.1460-2075.1994.tb06368.x","volume":"13","author":"Poli","year":"1994","journal-title":"EMBO J."},{"key":"10.1074\/jbc.270.19.11463_bib44","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/368339a0","volume":"368","author":"Kopf","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.270.19.11463_bib45","doi-asserted-by":"crossref","first-page":"24563","DOI":"10.1016\/S0021-9258(18)35801-0","volume":"267","author":"Pognonec","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.270.19.11463_bib46","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/j.1460-2075.1992.tb05097.x","volume":"11","author":"Xanthoudakis","year":"1992","journal-title":"EMBO J."},{"key":"10.1074\/jbc.270.19.11463_bib47","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.2118682","volume":"249","author":"Abate","year":"1990","journal-title":"Science"},{"key":"10.1074\/jbc.270.19.11463_bib48","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0092-8674(92)90162-6","volume":"70","author":"Hunter","year":"1992","journal-title":"Cell"},{"key":"10.1074\/jbc.270.19.11463_bib49","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1126\/science.256.5055.370","volume":"256","author":"Wegner","year":"1992","journal-title":"Science"},{"key":"10.1074\/jbc.270.19.11463_bib50","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1101\/gad.5.10.1754","volume":"5","author":"Metz","year":"1991","journal-title":"Genes & Dev."},{"key":"10.1074\/jbc.270.19.11463_bib51","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/364544a0","volume":"364","author":"Trautwein","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.270.19.11463_bib52","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0092-8674(89)90438-8","volume":"58","author":"Taga","year":"1989","journal-title":"Cell"},{"key":"10.1074\/jbc.270.19.11463_bib53","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/0092-8674(90)90411-7","volume":"63","author":"Hibi","year":"1990","journal-title":"Cell"},{"key":"10.1074\/jbc.270.19.11463_bib54","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0896-6273(91)90258-2","volume":"7","author":"Bazan","year":"1991","journal-title":"Neuron"},{"key":"10.1074\/jbc.270.19.11463_bib55","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1096\/fasebj.6.15.1334470","volume":"6","author":"Taga","year":"1992","journal-title":"FASEB J."},{"key":"10.1074\/jbc.270.19.11463_bib56","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1126\/science.2011743","volume":"251","author":"Oppenheim","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.270.19.11463_bib19","first-page":"11","volume":"24","author":"Gumkowski","year":"1987","journal-title":"Blood Vessels"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817502215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817502215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.270.19.11463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T12:56:03Z","timestamp":1682168163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925817502215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5]]},"references-count":56,"journal-issue":{"issue":"19","published-print":{"date-parts":[[1995,5]]}},"alternative-id":["S0021925817502215"],"URL":"https:\/\/doi.org\/10.1074\/jbc.270.19.11463","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1995,5]]}}}