{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:50:44Z","timestamp":1791287444431,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"27","license":[{"start":{"date-parts":[[1995,7,1]],"date-time":"1995-07-01T00:00:00Z","timestamp":804556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":9266,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1995,7]]},"DOI":"10.1074\/jbc.270.27.16409","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:52:50Z","timestamp":1027695170000},"page":"16409-16414","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":283,"title":["Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITY"],"prefix":"10.1016","volume":"270","author":[{"given":"Ralf","family":"Wienecke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"DeClue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.270.27.16409_bib1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0968-0004(90)90300-Z","volume":"15","author":"Downward","year":"1990","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.270.27.16409_bib2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/348125a0","volume":"348","author":"Bourne","year":"1990","journal-title":"Nature"},{"key":"10.1074\/jbc.270.27.16409_bib3","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/366643a0","volume":"366","author":"Boguski","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.270.27.16409_bib4","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1146\/annurev.bi.62.070193.004223","volume":"62","author":"Lowy","year":"1993","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.270.27.16409_bib5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev.cb.07.110191.003125","volume":"7","author":"Bollag","year":"1991","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1074\/jbc.270.27.16409_bib6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0092-8674(95)90403-4","volume":"80","author":"Hill","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.270.27.16409_bib7","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/356713a0","volume":"356","author":"Basu","year":"1992","journal-title":"Nature"},{"key":"10.1074\/jbc.270.27.16409_bib8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0092-8674(92)90407-4","volume":"69","author":"DeClue","year":"1992","journal-title":"Cell"},{"key":"10.1074\/jbc.270.27.16409_bib9","series-title":"Tuberous Sclerosis","author":"Gomez","year":"1988"},{"key":"10.1074\/jbc.270.27.16409_bib10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/BF00201608","volume":"94","author":"Janssen","year":"1994","journal-title":"Hum. Genet."},{"key":"10.1074\/jbc.270.27.16409_bib11","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000133566","volume":"64","author":"Kwiatkowski","year":"1993","journal-title":"Cytogenet. Cell Genet."},{"key":"10.1074\/jbc.270.27.16409_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/ng0294-193","volume":"6","author":"Green","year":"1994","journal-title":"Nature Genet."},{"key":"10.1074\/jbc.270.27.16409_bib13","doi-asserted-by":"crossref","first-page":"11413","DOI":"10.1073\/pnas.91.24.11413","volume":"91","author":"Yeung","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.270.27.16409_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/ng0195-70","volume":"9","author":"Kobayashi","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.270.27.16409_bib15","first-page":"1305","volume":"75","year":"1993","journal-title":"Cell The European Chromosome 16 Tuberous Sclerosis Consortium"},{"key":"10.1074\/jbc.270.27.16409_bib16","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.1093\/nar\/16.15.7719","volume":"16","author":"Pizon","year":"1988","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.270.27.16409_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0092-8674(89)90985-9","volume":"56","author":"Kitayama","year":"1989","journal-title":"Cell"},{"key":"10.1074\/jbc.270.27.16409_bib18","first-page":"3407","volume":"12","author":"Yoshida","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.270.27.16409_bib19","series-title":"PCR Technology: Principles and Applications for DNA Amplification","first-page":"99","author":"Tung","year":"1989"},{"key":"10.1074\/jbc.270.27.16409_bib20","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1002\/j.1460-2075.1992.tb05494.x","volume":"11","author":"Cen","year":"1992","journal-title":"EMBO J."},{"key":"10.1074\/jbc.270.27.16409_bib21","series-title":"Antibodies: A Laboratory Manual","author":"Harlow","year":"1988"},{"key":"10.1074\/jbc.270.27.16409_bib22","doi-asserted-by":"crossref","first-page":"9914","DOI":"10.1073\/pnas.88.22.9914","volume":"88","author":"DeClue","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.270.27.16409_bib23","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.1749934","volume":"254","author":"Zhang","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.270.27.16409_bib24","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1016\/S0021-9258(20)64324-1","volume":"266","author":"Lerosey","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.270.27.16409_bib25","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1182\/blood.V77.5.909.909","volume":"77","author":"L\u00fcbbert","year":"1991","journal-title":"Blood"},{"key":"10.1074\/jbc.270.27.16409_bib26","first-page":"4634","volume":"12","author":"Rubinfeld","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.270.27.16409_bib27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1073\/pnas.88.1.239","volume":"88","author":"Polakis","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.270.27.16409_bib28","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0092-8674(91)90066-8","volume":"67","author":"Hariharan","year":"1991","journal-title":"Cell"},{"key":"10.1074\/jbc.270.27.16409_bib29","first-page":"201","volume":"3","author":"Pizon","year":"1988","journal-title":"Oncogene"},{"key":"10.1074\/jbc.270.27.16409_bib30","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1242\/jcs.107.6.1661","volume":"107","author":"Pizon","year":"1994","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.270.27.16409_bib31","first-page":"641","volume":"14","author":"Johnson","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.270.27.16409_bib32","author":"Kim","year":"1995","journal-title":"Oncogene"},{"key":"10.1074\/jbc.270.27.16409_bib33","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1002\/j.1460-2075.1993.tb06022.x","volume":"12","author":"Cook","year":"1993","journal-title":"EMBO J."},{"key":"10.1074\/jbc.270.27.16409_bib34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1126\/science.2164710","volume":"249","author":"Frech","year":"1990","journal-title":"Science"},{"key":"10.1074\/jbc.270.27.16409_bib35","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/364308a0","volume":"364","author":"Zhang","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.270.27.16409_bib36","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0092-8674(91)90555-D","volume":"65","author":"Rubinfeld","year":"1991","journal-title":"Cell"},{"key":"10.1074\/jbc.270.27.16409_bib37","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1128\/MCB.15.1.552","volume":"15","author":"Hattori","year":"1995","journal-title":"Mol. Cell. Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817488776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925817488776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.270.27.16409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T22:15:38Z","timestamp":1702073738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925817488776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,7]]},"references-count":37,"journal-issue":{"issue":"27","published-print":{"date-parts":[[1995,7]]}},"alternative-id":["S0021925817488776"],"URL":"https:\/\/doi.org\/10.1074\/jbc.270.27.16409","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1995,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITY","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1074\/jbc.270.27.16409","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 1995 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}]}}