{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:29:49Z","timestamp":1791307789530,"version":"4.3.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"48","license":[{"start":{"date-parts":[[1995,12,1]],"date-time":"1995-12-01T00:00:00Z","timestamp":817776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T00:00:00Z","timestamp":1604707200000},"content-version":"vor","delay-in-days":9108,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1995,12]]},"DOI":"10.1074\/jbc.270.48.28696","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:53:54Z","timestamp":1027680834000},"page":"28696-28704","source":"Crossref","is-referenced-by-count":79,"title":["Peptide Probe of Ryanodine Receptor Function IMPERATOXIN A, A PEPTIDE FROM THE VENOM OF THE SCORPION PANDINUS IMPERATOR, SELECTIVELY ACTIVATES SKELETAL-TYPE RYANODINE RECEPTOR ISOFORMS"],"prefix":"10.1016","volume":"270","author":[{"given":"Roque","family":"El-Hayek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Lokuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ar\u00e9valo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector H.","family":"Valdivia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.270.48.28696_bib1","series-title":"Excitation-contraction Coupling and Cardiac Contractile Force","author":"Bers","year":"1991"},{"key":"10.1074\/jbc.270.48.28696_bib2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0896-6273(90)90304-X","volume":"5","author":"Ellisman","year":"1990","journal-title":"Neuron"},{"key":"10.1074\/jbc.270.48.28696_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0896-6273(91)90070-G","volume":"7","author":"McPherson","year":"1991","journal-title":"Neuron"},{"key":"10.1074\/jbc.270.48.28696_bib4","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1042\/bj2680699","volume":"268","author":"Shoshan-Barmatz","year":"1990","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.270.48.28696_bib5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF00550873","volume":"418","author":"Herrmann-Frank","year":"1991","journal-title":"Pfluegers Arch."},{"key":"10.1074\/jbc.270.48.28696_bib6","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1073\/pnas.91.8.3294","volume":"91","author":"Xu","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.270.48.28696_bib7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.1320290","volume":"257","author":"Giannini","year":"1992","journal-title":"Science (Wash. D. C.)"},{"key":"10.1074\/jbc.270.48.28696_bib8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/978-1-4615-3362-7_56","volume":"311","author":"Rardon","year":"1992","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1074\/jbc.270.48.28696_bib9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/370307a0","volume":"370","author":"Lee","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.270.48.28696_bib10","doi-asserted-by":"crossref","first-page":"C1485","DOI":"10.1152\/ajpcell.1994.266.6.C1485","volume":"35","author":"Coronado","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.270.48.28696_bib11","doi-asserted-by":"crossref","first-page":"13472","DOI":"10.1016\/S0021-9258(18)77371-7","volume":"265","author":"Otsu","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.270.48.28696_bib12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0014-5793(92)80941-9","volume":"312","author":"Hakamata","year":"1992","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.270.48.28696_bib13","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/339439a0","volume":"339","author":"Takeshima","year":"1989","journal-title":"Nature"},{"key":"10.1074\/jbc.270.48.28696_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1085\/jgp.92.1.1","volume":"92","author":"Smith","year":"1989","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.270.48.28696_bib15","doi-asserted-by":"crossref","first-page":"C364","DOI":"10.1152\/ajpcell.1987.253.3.C364","volume":"253","author":"Rousseau","year":"1987","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.270.48.28696_bib16","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0006-3495(89)82722-5","volume":"56","author":"Bull","year":"1989","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.270.48.28696_bib17","doi-asserted-by":"crossref","first-page":"23560","DOI":"10.1016\/S0021-9258(18)35875-7","volume":"267","author":"Buck","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.270.48.28696_bib18","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1085\/jgp.104.3.425","volume":"104","author":"Lindsay","year":"1994","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.270.48.28696_bib19","first-page":"232","volume":"31","author":"Pessah","year":"1987","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.270.48.28696_bib20","first-page":"735","volume":"37","author":"Chu","year":"1990","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.270.48.28696_bib21","first-page":"119","volume":"114","author":"Meissner","year":"1992","journal-title":"J. Biochem."},{"key":"10.1074\/jbc.270.48.28696_bib22","doi-asserted-by":"crossref","first-page":"15637","DOI":"10.1016\/S0021-9258(18)47774-5","volume":"262","author":"Inui","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.270.48.28696_bib23","doi-asserted-by":"crossref","first-page":"16636","DOI":"10.1016\/S0021-9258(18)49303-9","volume":"262","author":"Imagawa","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.270.48.28696_bib24","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/331543a0","volume":"331","author":"Lai","year":"1988","journal-title":"Nature"},{"key":"10.1074\/jbc.270.48.28696_bib25","first-page":"861","volume":"256","author":"Seino","year":"1991","journal-title":"J. Pharmacol. Exp. Therap."},{"key":"10.1074\/jbc.270.48.28696_bib26","doi-asserted-by":"crossref","first-page":"19135","DOI":"10.1016\/S0021-9258(18)54969-3","volume":"266","author":"Valdivia","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.270.48.28696_bib27","doi-asserted-by":"crossref","first-page":"12185","DOI":"10.1073\/pnas.89.24.12185","volume":"89","author":"Valdivia","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.270.48.28696_bib28","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0006-3495(93)81101-9","volume":"65","author":"El-Hayek","year":"1993","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.270.48.28696_bib29","doi-asserted-by":"crossref","first-page":"15475","DOI":"10.1016\/S0021-9258(19)49559-8","volume":"267","author":"Sabbadini","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.270.48.28696_bib30","doi-asserted-by":"crossref","first-page":"15894","DOI":"10.1016\/S0021-9258(18)55483-1","volume":"265","author":"D\u00edaz-Mu\u00f1oz","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.270.48.28696_bib31","doi-asserted-by":"crossref","first-page":"9474","DOI":"10.1016\/S0021-9258(19)50114-4","volume":"267","author":"Jayaraman","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.270.48.28696_bib32","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/oxfordjournals.jbchem.a124691","volume":"116","author":"Valdivia","year":"1994","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1074\/jbc.270.48.28696_bib33","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1016\/S0021-9258(17)43361-8","volume":"259","author":"Meissner","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.270.48.28696_bib34","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1085\/jgp.78.5.457","volume":"78","author":"Fabiato","year":"1981","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.270.48.28696_bib35","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1016\/S0021-9258(19)39968-5","volume":"265","author":"Zorzato","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.270.48.28696_bib36","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0006-3495(90)82563-7","volume":"60","author":"Fill","year":"1990","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.270.48.28696_bib37","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF00234651","volume":"135","author":"Chu","year":"1993","journal-title":"J. Membr. Biol."},{"key":"10.1074\/jbc.270.48.28696_bib38","first-page":"A418","volume":"66","author":"Valdivia","year":"1994","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.270.48.28696_bib39","first-page":"503","volume":"37","author":"Pessah","year":"1990","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.270.48.28696_bib40","doi-asserted-by":"crossref","first-page":"C237","DOI":"10.1152\/ajpcell.1991.261.2.C237","volume":"261","author":"Valdivia","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.270.48.28696_bib41","first-page":"938","volume":"256","author":"Zymanyi","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.270.48.28696_bib42","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1016\/S0006-3495(94)80664-2","volume":"67","author":"Hain","year":"1994","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.270.48.28696_bib43","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1016\/S0021-9258(18)61469-3","volume":"262","author":"Meissner","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.270.48.28696_bib44","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1126\/science.7701323","volume":"267","author":"Valdivia","year":"1995","journal-title":"Science (Wash. D. C.)"},{"key":"10.1074\/jbc.270.48.28696_bib45","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/BF00141551","volume":"14","author":"Lamb","year":"1993","journal-title":"J. Muscle Res. Cell Motil."},{"key":"10.1074\/jbc.270.48.28696_bib46","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00233486","volume":"137","author":"McGarry","year":"1994","journal-title":"J. Membr. Biol."},{"key":"10.1074\/jbc.270.48.28696_bib47","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1126\/science.8387229","volume":"260","author":"Gyorke","year":"1993","journal-title":"Science (Wash. D. C.)"},{"key":"10.1074\/jbc.270.48.28696_bib48","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1073\/pnas.83.8.2345","volume":"83","author":"Knox","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.270.48.28696_bib49","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1126\/science.7701326","volume":"267","author":"Cheng","year":"1995","journal-title":"Science (Wash. D. C.)"},{"key":"10.1074\/jbc.270.48.28696_bib50","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0003-2697(79)90115-5","volume":"100","author":"Lanzetta","year":"1979","journal-title":"Anal. Biochem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818878255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818878255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.270.48.28696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T00:13:26Z","timestamp":1641082406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818878255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12]]},"references-count":50,"journal-issue":{"issue":"48","published-print":{"date-parts":[[1995,12]]}},"alternative-id":["S0021925818878255"],"URL":"https:\/\/doi.org\/10.1074\/jbc.270.48.28696","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1995,12]]}}}