{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:56:54Z","timestamp":1780387014358,"version":"3.54.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1996,1,1]],"date-time":"1996-01-01T00:00:00Z","timestamp":820454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":9080,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1996,1]]},"DOI":"10.1074\/jbc.271.1.505","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:15:23Z","timestamp":1027696523000},"page":"505-511","source":"Crossref","is-referenced-by-count":90,"title":["Platelet-derived Growth Factor Stimulates Protein Kinase A through a Mitogen-activated Protein Kinase-dependent Pathway in Human Arterial Smooth Muscle Cells"],"prefix":"10.1016","volume":"271","author":[{"given":"Lee M.","family":"Graves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin E.","family":"Bornfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaspreet S.","family":"Sidhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen M.","family":"Argast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine W.","family":"Raines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina C.","family":"Leslie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin G.","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.271.1.505_bib1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/362801a0","volume":"362","author":"Ross","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.271.1.505_bib2","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1126\/science.1411546","volume":"258","author":"Crews","year":"1992","journal-title":"Science"},{"key":"10.1074\/jbc.271.1.505_bib3","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/370508a0","volume":"370","author":"Feig","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.271.1.505_bib4","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(94)90133-3","volume":"77","author":"Cowley","year":"1994","journal-title":"Cell"},{"key":"10.1074\/jbc.271.1.505_bib5","doi-asserted-by":"crossref","first-page":"25699","DOI":"10.1016\/S0021-9258(18)47305-X","volume":"269","author":"Seger","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib6","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1126\/science.8052857","volume":"265","author":"Mansour","year":"1994","journal-title":"Science"},{"key":"10.1074\/jbc.271.1.505_bib7","doi-asserted-by":"crossref","first-page":"14553","DOI":"10.1016\/S0021-9258(18)82362-6","volume":"268","author":"Davis","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib8","doi-asserted-by":"crossref","first-page":"13057","DOI":"10.1016\/S0021-9258(17)36794-7","volume":"269","author":"Dennis","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib9","series-title":"Signal-activated Phospholipases","first-page":"13","author":"Kramer","year":"1995"},{"key":"10.1074\/jbc.271.1.505_bib10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/0165-6147(93)90071-Q","volume":"14","author":"Glaser","year":"1993","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1074\/jbc.271.1.505_bib11","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1096\/fasebj.8.12.8088457","volume":"8","author":"Gelb","year":"1994","journal-title":"FASEB J."},{"key":"10.1074\/jbc.271.1.505_bib12","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1016\/S0021-9258(19)39374-3","volume":"265","author":"Channon","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0092-8674(93)90666-E","volume":"72","author":"Lin","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.271.1.505_bib14","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/S0021-9258(18)53948-X","volume":"268","author":"Nemenoff","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib15","doi-asserted-by":"crossref","first-page":"19480","DOI":"10.1016\/S0021-9258(17)32194-4","volume":"269","author":"Qui","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0005-2760(92)90183-V","volume":"1165","author":"Miyake","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.271.1.505_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1074\/jbc.270.1.1","volume":"270","author":"Taussig","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib18","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0092-8674(83)90157-5","volume":"34","author":"Rozengurt","year":"1983","journal-title":"Cell"},{"key":"10.1074\/jbc.271.1.505_bib19","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1042\/bj2640563","volume":"264","author":"Nair","year":"1989","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.271.1.505_bib20","doi-asserted-by":"crossref","first-page":"12836","DOI":"10.1016\/S0021-9258(19)38235-3","volume":"265","author":"Ball","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0014-4827(85)90241-1","volume":"160","author":"Loesberg","year":"1985","journal-title":"Exp. Cell. Res."},{"key":"10.1074\/jbc.271.1.505_bib22","doi-asserted-by":"crossref","first-page":"10300","DOI":"10.1073\/pnas.90.21.10300","volume":"90","author":"Graves","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.271.1.505_bib23","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1126\/science.7694366","volume":"262","author":"Wu","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.271.1.505_bib24","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1126\/science.7694367","volume":"262","author":"Cook","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.271.1.505_bib25","doi-asserted-by":"crossref","first-page":"10305","DOI":"10.1073\/pnas.90.21.10305","volume":"90","author":"Sevetson","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.271.1.505_bib26","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1002\/j.1460-2075.1993.tb06105.x","volume":"12","author":"Burgering","year":"1993","journal-title":"EMBO J."},{"key":"10.1074\/jbc.271.1.505_bib27","first-page":"6696","volume":"14","author":"Hafner","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1074\/jbc.271.1.505_bib28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0968-0004(00)88944-6","volume":"20","author":"Burgering","year":"1995","journal-title":"Trends Biochem. Sci."},{"key":"10.1074\/jbc.271.1.505_bib29","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0076-6879(91)01027-Y","volume":"201","author":"Walsh","year":"1991","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.271.1.505_bib30","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1016\/S0021-9258(17)40137-2","volume":"252","author":"Kemp","year":"1977","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib31","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1006\/abbi.1993.1549","volume":"306","author":"deCarvalho","year":"1993","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.271.1.505_bib32","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1172\/JCI117081","volume":"93","author":"Bornfeldt","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.271.1.505_bib33","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0076-6879(83)99057-2","volume":"99","author":"Corbin","year":"1983","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.271.1.505_bib34","doi-asserted-by":"crossref","first-page":"8927","DOI":"10.1016\/S0021-9258(18)52961-6","volume":"268","author":"Domin","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0955-0674(93)90115-7","volume":"5","author":"Choi","year":"1993","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.271.1.505_bib36","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1096\/fasebj.7.9.8330684","volume":"7","author":"Iyengar","year":"1993","journal-title":"FASEB J."},{"key":"10.1074\/jbc.271.1.505_bib37","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1073\/pnas.87.7.2466","volume":"87","author":"Thastrup","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Suppl. I","key":"10.1074\/jbc.271.1.505_bib38","first-page":"34","volume":"14","author":"Schror","year":"1993","journal-title":"Eur. Heart J."},{"key":"10.1074\/jbc.271.1.505_bib39","doi-asserted-by":"crossref","first-page":"5935","DOI":"10.1021\/bi00074a003","volume":"32","author":"Street","year":"1993","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.271.1.505_bib40","doi-asserted-by":"crossref","first-page":"15625","DOI":"10.1016\/S0021-9258(17)40727-7","volume":"269","author":"Bartoli","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib41","doi-asserted-by":"crossref","first-page":"32023","DOI":"10.1016\/S0021-9258(18)31591-6","volume":"269","author":"Claesson-Welsh","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0014-2999(86)90553-4","volume":"128","author":"Vegesna","year":"1986","journal-title":"Eur. J. Pharmacol."},{"key":"10.1074\/jbc.271.1.505_bib43","first-page":"429","volume":"14","author":"Rozengurt","year":"1981","journal-title":"Adv. Cyclic Nucleotide Res."},{"key":"10.1074\/jbc.271.1.505_bib44","doi-asserted-by":"crossref","first-page":"21317","DOI":"10.1016\/S0021-9258(17)45362-2","volume":"265","author":"Nair","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib45","doi-asserted-by":"crossref","first-page":"13908","DOI":"10.1016\/S0021-9258(18)92787-0","volume":"266","author":"Budnik","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib46","doi-asserted-by":"crossref","first-page":"5990","DOI":"10.1016\/S0021-9258(19)39281-6","volume":"265","author":"Hart","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib47","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1074\/jbc.270.5.2360","volume":"270","author":"Sa","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib48","doi-asserted-by":"crossref","first-page":"16554","DOI":"10.1016\/S0021-9258(19)89424-3","volume":"269","author":"Kawabe","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib49","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1021\/bi00059a001","volume":"32","author":"Choi","year":"1993","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.271.1.505_bib50","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1016\/S0021-9258(18)53547-X","volume":"268","author":"Jacobowitz","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.1.505_bib51","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1083\/jcb.130.1.193","volume":"130","author":"Bornfeldt","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.271.1.505_bib52","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/bj3040611","volume":"304","author":"Pyne","year":"1994","journal-title":"Biochem. J."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818953706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818953706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.271.1.505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T09:13:57Z","timestamp":1641114837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818953706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["S0021925818953706"],"URL":"https:\/\/doi.org\/10.1074\/jbc.271.1.505","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1996,1]]}}}