{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:16:24Z","timestamp":1791274584510,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"27","license":[{"start":{"date-parts":[[1996,7,1]],"date-time":"1996-07-01T00:00:00Z","timestamp":836179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":8877,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1996,7]]},"DOI":"10.1074\/jbc.271.27.15950","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:14:15Z","timestamp":1027696455000},"page":"15950-15962","source":"Crossref","is-referenced-by-count":369,"title":["Molecular Determinants of High Affinity Binding of \u03b1-Scorpion Toxin and Sea Anemone Toxin in the S3-S4 Extracellular Loop in Domain IV of the Na+ Channel \u03b1 Subunit"],"prefix":"10.1016","volume":"271","author":[{"given":"John C.","family":"Rogers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy N.","family":"Tanada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Scheuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Catterall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.271.27.15950_bib1","series-title":"Ionic Channels of Excitable Membranes","author":"Hille","year":"1992"},{"key":"10.1074\/jbc.271.27.15950_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev.pa.20.040180.000311","volume":"20","author":"Catterall","year":"1980","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1074\/jbc.271.27.15950_bib3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev.bi.64.070195.002425","volume":"64","author":"Catterall","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"10.1074\/jbc.271.27.15950_bib4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0959-4388(92)90110-7","volume":"2","author":"St\u00fchmer","year":"1992","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1074\/jbc.271.27.15950_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0041-0101(82)90137-4","volume":"20","author":"Fontecilla-Camps","year":"1982","journal-title":"Toxicon"},{"key":"10.1074\/jbc.271.27.15950_bib6","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.1073\/pnas.85.20.7443","volume":"85","author":"Fontecilla-Camps","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.271.27.15950_bib7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0014-5793(88)80931-1","volume":"239","author":"Torda","year":"1988","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.271.27.15950_bib8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/prot.340060403","volume":"6","author":"Widmer","year":"1989","journal-title":"Proteins"},{"key":"10.1074\/jbc.271.27.15950_bib9","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1021\/bi00430a060","volume":"28","author":"Fogh","year":"1990","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.271.27.15950_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1432-1033.1986.tb09488.x","volume":"155","author":"El Ayeb","year":"1986","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.271.27.15950_bib11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1432-1033.1989.tb14735.x","volume":"181","author":"Kharrat","year":"1989","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.271.27.15950_bib12","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0041-0101(90)90295-I","volume":"28","author":"Kharrat","year":"1990","journal-title":"Toxicon"},{"key":"10.1074\/jbc.271.27.15950_bib13","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.1016\/S0021-9258(19)69272-0","volume":"256","author":"Barhanin","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.27.15950_bib14","doi-asserted-by":"crossref","first-page":"16785","DOI":"10.1016\/S0021-9258(19)89460-7","volume":"269","author":"Lorett","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.27.15950_bib15","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0021-9258(17)42342-8","volume":"269","author":"Gallagher","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.27.15950_bib16","doi-asserted-by":"crossref","first-page":"8533","DOI":"10.1021\/bi00027a003","volume":"34","author":"Khera","year":"1995","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.271.27.15950_bib17","doi-asserted-by":"crossref","first-page":"8660","DOI":"10.1016\/S0021-9258(19)75272-7","volume":"252","author":"Catterall","year":"1977","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.27.15950_bib18","doi-asserted-by":"crossref","first-page":"7393","DOI":"10.1016\/S0021-9258(17)34513-1","volume":"253","author":"Catterall","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.27.15950_bib19","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1085\/jgp.74.3.375","volume":"74","author":"Catterall","year":"1979","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.271.27.15950_bib20","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0005-2736(80)90230-8","volume":"597","author":"Mozhayeva","year":"1980","journal-title":"Biochim Biophys Acta"},{"key":"10.1074\/jbc.271.27.15950_bib21","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF00584827","volume":"402","author":"Meves","year":"1984","journal-title":"Pfluegers Arch."},{"key":"10.1074\/jbc.271.27.15950_bib22","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1085\/jgp.88.3.413","volume":"88","author":"Strichartz","year":"1986","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.271.27.15950_bib23","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1085\/jgp.86.5.739","volume":"86","author":"Wang","year":"1985","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.271.27.15950_bib24","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1073\/pnas.77.1.639","volume":"77","author":"Beneski","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.271.27.15950_bib25","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0006-291X(83)80160-0","volume":"115","author":"Darbon","year":"1983","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.271.27.15950_bib26","doi-asserted-by":"crossref","first-page":"6078","DOI":"10.1021\/bi00320a027","volume":"23","author":"Sharkey","year":"1984","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.271.27.15950_bib27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0896-6273(92)90108-P","volume":"8","author":"West","year":"1992","journal-title":"Neuron"},{"key":"10.1074\/jbc.271.27.15950_bib28","doi-asserted-by":"crossref","first-page":"8742","DOI":"10.1073\/pnas.85.22.8742","volume":"85","author":"Tejedor","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.271.27.15950_bib29","doi-asserted-by":"crossref","first-page":"10161","DOI":"10.1073\/pnas.86.24.10161","volume":"86","author":"Thomsen","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.271.27.15950_bib30","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/320188a0","volume":"320","author":"Noda","year":"1986","journal-title":"Nature"},{"key":"10.1074\/jbc.271.27.15950_bib31","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0896-6273(88)90176-6","volume":"1","author":"Auld","year":"1988","journal-title":"Neuron"},{"key":"10.1074\/jbc.271.27.15950_bib32","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1073\/pnas.87.1.323","volume":"87","author":"Auld","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.271.27.15950_bib33","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1073\/pnas.82.2.488","volume":"82","author":"Kunkel","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.271.27.15950_bib34","doi-asserted-by":"crossref","first-page":"8170","DOI":"10.1073\/pnas.86.20.8170","volume":"86","author":"Rogart","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.271.27.15950_bib35","first-page":"906","volume":"15","author":"Margolskee","year":"1993","journal-title":"BioTechniques"},{"key":"10.1074\/jbc.271.27.15950_bib36","first-page":"876","volume":"17","author":"Jurman","year":"1994","journal-title":"BioTechniques"},{"key":"10.1074\/jbc.271.27.15950_bib37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0076-6879(83)91014-5","volume":"91","author":"Peterson","year":"1983","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.271.27.15950_bib38","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1074\/jbc.270.7.3306","volume":"270","author":"Isom","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.271.27.15950_bib39","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1073\/pnas.91.8.3289","volume":"91","author":"Qu","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.271.27.15950_bib40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0006-3495(88)83063-7","volume":"53","author":"Levitt","year":"1988","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.271.27.15950_bib41","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF01871764","volume":"106","author":"Nagy","year":"1988","journal-title":"J. Membr. Biol."},{"key":"10.1074\/jbc.271.27.15950_bib42","first-page":"3","volume":"9","author":"Mozhayeva","year":"1990","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1074\/jbc.271.27.15950_bib43","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0014-5793(85)80136-8","volume":"193","author":"Greenblatt","year":"1985","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.271.27.15950_bib44","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1073\/pnas.83.2.508","volume":"83","author":"Guy","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.271.27.15950_bib45","unstructured":"Predict-Protein@EMBL-Heidelberg.de (1995) http:\/\/www.public.iastate.edu\/mfpedro\/pprotein_query.html."},{"key":"10.1074\/jbc.271.27.15950_bib46","first-page":"533","volume":"20","author":"Catterall","year":"1981","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.271.27.15950_bib47","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1523\/JNEUROSCI.04-11-02836.1984","volume":"4","author":"Gonoi","year":"1984","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.271.27.15950_bib48","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0022-2836(65)80285-6","volume":"12","author":"Monod","year":"1965","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.271.27.15950_bib49","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0006-291X(78)80053-9","volume":"85","author":"Jover","year":"1978","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.271.27.15950_bib50","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1085\/jgp.70.5.567","volume":"70","author":"Armstrong","year":"1977","journal-title":"J. Gen. Physiol."},{"key":"10.1074\/jbc.271.27.15950_bib51","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/BF01066234","volume":"12","author":"Mozhayeva","year":"1981","journal-title":"Neurophysiology"},{"key":"10.1074\/jbc.271.27.15950_bib52","first-page":"345","volume":"3","author":"Nonner","year":"1979","journal-title":"Adv. Cytopharmacol."},{"key":"10.1074\/jbc.271.27.15950_bib53","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0005-2736(85)90425-0","volume":"814","author":"Neumcke","year":"1985","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.271.27.15950_bib54","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0896-6273(95)90078-0","volume":"15","author":"Yang","year":"1995","journal-title":"Neuron"},{"key":"10.1074\/jbc.271.27.15950_bib55","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/ana.410330312","volume":"33","author":"Ptacek","year":"1993","journal-title":"Ann. Neurol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818485663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818485663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.271.27.15950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T13:10:12Z","timestamp":1641042612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818485663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":55,"journal-issue":{"issue":"27","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["S0021925818485663"],"URL":"https:\/\/doi.org\/10.1074\/jbc.271.27.15950","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}