{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:11:44Z","timestamp":1791159104758,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"39","license":[{"start":{"date-parts":[[1996,9,1]],"date-time":"1996-09-01T00:00:00Z","timestamp":841536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"vor","delay-in-days":8805,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1996,9]]},"DOI":"10.1074\/jbc.271.39.23646","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:50:28Z","timestamp":1027695028000},"page":"23646-23649","source":"Crossref","is-referenced-by-count":311,"title":["Highly Potent, Selective, and Low Cost Bis-tetrahydroaminacrine Inhibitors of Acetylcholinesterase"],"prefix":"10.1016","volume":"271","author":[{"given":"Yuan-Ping","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly","family":"Quiram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Jelacic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Brimijoin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.271.39.23646_bib1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0140-6736(95)90526-X","volume":"345","author":"Davis","year":"1995","journal-title":"Lancet"},{"key":"10.1074\/jbc.271.39.23646_bib2","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1021\/cr00081a005","volume":"87","author":"Quinn","year":"1987","journal-title":"Chem. Rev."},{"key":"10.1074\/jbc.271.39.23646_bib3","series-title":"Multidisciplinary Approaches to Cholinesterase Functions","first-page":"95","author":"Sussman","year":"1992"},{"key":"10.1074\/jbc.271.39.23646_bib4","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/BF00124014","volume":"8","author":"Pang","year":"1994","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1074\/jbc.271.39.23646_bib5","doi-asserted-by":"crossref","first-page":"9031","DOI":"10.1073\/pnas.90.19.9031","volume":"90","author":"Harel","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.271.39.23646_bib6","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/BF02174469","volume":"6","author":"Pang","year":"1995","journal-title":"Perspect. Drug Discovery Des."},{"key":"10.1074\/jbc.271.39.23646_bib7","doi-asserted-by":"crossref","first-page":"12074","DOI":"10.1021\/bi00096a018","volume":"32","author":"Radic","year":"1993","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.271.39.23646_bib8","first-page":"335","volume":"45","author":"Eichler","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.271.39.23646_bib9","first-page":"306","volume":"2","author":"Pomponi","year":"1992","journal-title":"Med. Chem. Res."},{"key":"10.1074\/jbc.271.39.23646_bib10","first-page":"412","volume":"41","author":"Berman","year":"1992","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.271.39.23646_bib11","first-page":"74","volume":"45","author":"Taylor","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.271.39.23646_bib12","doi-asserted-by":"crossref","first-page":"10827","DOI":"10.1073\/pnas.89.22.10827","volume":"89","author":"Harel","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.271.39.23646_bib13","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1126\/science.1678899","volume":"253","author":"Sussman","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.271.39.23646_bib14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0022-5193(62)90037-1","volume":"2","author":"Koshland","year":"1962","journal-title":"J. Theor. Biol."},{"key":"10.1074\/jbc.271.39.23646_bib15","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1021\/jm00245a002","volume":"18","author":"Steinberg","year":"1975","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.271.39.23646_bib16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcc.540040211","volume":"4","author":"Brooks","year":"1983","journal-title":"J. Comput. Chem."},{"key":"10.1074\/jbc.271.39.23646_bib17","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1126\/science.2727695","volume":"244","author":"Gao","year":"1989","journal-title":"Science"},{"key":"10.1074\/jbc.271.39.23646_bib18","series-title":"Enzyme Kinetics","author":"Segel","year":"1975"},{"key":"10.1074\/jbc.271.39.23646_bib19","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1021\/jm00015a002","volume":"38","author":"Villalobos","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.271.39.23646_bib20","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1021\/jm00128a024","volume":"32","author":"Shutske","year":"1989","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.271.39.23646_bib21","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0960-894X(00)80547-8","volume":"8","author":"Sugimoto","year":"1992","journal-title":"Bioorg. & Med. Chem. Lett."},{"key":"10.1074\/jbc.271.39.23646_bib22","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1139\/v86-137","volume":"64","author":"Liu","year":"1986","journal-title":"Can. J. Chem."},{"key":"10.1074\/jbc.271.39.23646_bib23","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1135\/cccc19760816","volume":"41","author":"Patocka","year":"1976","journal-title":"Collect. Czech. Chem. Commun."},{"key":"10.1074\/jbc.271.39.23646_bib24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1021\/jm00004a005","volume":"38","author":"Galanakis","year":"1995","journal-title":"J. Med. Chem."},{"key":"10.1074\/jbc.271.39.23646_bib25","first-page":"151","volume":"46","author":"Nelson","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.271.39.23646_bib26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1476-5381.1987.tb11352.x","volume":"92","author":"Osterrieder","year":"1987","journal-title":"Br. J. Pharmacol."},{"key":"10.1074\/jbc.271.39.23646_bib27","first-page":"573","volume":"250","author":"Flynn","year":"1989","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1074\/jbc.271.39.23646_bib28","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0896-6273(00)80108-7","volume":"16","author":"Inestrosa","year":"1996","journal-title":"Neuron"},{"key":"10.1074\/jbc.271.39.23646_bib29","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/0006-3002(55)90040-8","volume":"18","author":"Wilson","year":"1955","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.271.39.23646_bib30","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/ana.410360506","volume":"36","author":"Mesulam","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.271.39.23646_bib31","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0024-3205(86)90530-8","volume":"39","author":"De la Hoz","year":"1986","journal-title":"Life Sci."},{"key":"10.1074\/jbc.271.39.23646_bib32","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818401275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818401275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.271.39.23646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T06:39:46Z","timestamp":1639809586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818401275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,9]]},"references-count":32,"journal-issue":{"issue":"39","published-print":{"date-parts":[[1996,9]]}},"alternative-id":["S0021925818401275"],"URL":"https:\/\/doi.org\/10.1074\/jbc.271.39.23646","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1996,9]]}}}