{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:53:58Z","timestamp":1790891638626,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"vor","delay-in-days":8593,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1997,4]]},"DOI":"10.1074\/jbc.272.17.11604","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:49:13Z","timestamp":1027694953000},"page":"11604-11612","source":"Crossref","is-referenced-by-count":80,"title":["Identification of Intermediate Steps in the Conversion of a Mutant Prion Protein to a Scrapie-like Form in Cultured Cells"],"prefix":"10.1016","volume":"272","author":[{"given":"Nathalie","family":"Daude","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.272.17.11604_bib1","series-title":"Virology","first-page":"2901","author":"Prusiner","year":"1996"},{"key":"10.1074\/jbc.272.17.11604_bib2","series-title":"Virology","first-page":"2851","author":"Gajdusek","year":"1996"},{"key":"10.1074\/jbc.272.17.11604_bib3","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0140-6736(96)91412-9","volume":"347","author":"Will","year":"1996","journal-title":"Lancet"},{"key":"10.1074\/jbc.272.17.11604_bib4","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00019052-199508000-00007","volume":"8","author":"Parchi","year":"1995","journal-title":"Curr. Opin. Neurol."},{"key":"10.1074\/jbc.272.17.11604_bib5","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1126\/science.7909169","volume":"264","author":"Cohen","year":"1994","journal-title":"Science"},{"key":"10.1074\/jbc.272.17.11604_bib6","doi-asserted-by":"crossref","first-page":"7672","DOI":"10.1021\/bi00245a003","volume":"30","author":"Caughey","year":"1991","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.272.17.11604_bib7","doi-asserted-by":"crossref","first-page":"20276","DOI":"10.1016\/S0021-9258(20)80725-X","volume":"268","author":"Safar","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.17.11604_bib8","doi-asserted-by":"crossref","first-page":"10962","DOI":"10.1073\/pnas.90.23.10962","volume":"90","author":"Pan","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.272.17.11604_bib9","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0092-8674(90)90134-Z","volume":"63","author":"Prusiner","year":"1990","journal-title":"Cell"},{"key":"10.1074\/jbc.272.17.11604_bib10","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/0092-8674(93)90275-U","volume":"73","author":"Scott","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.272.17.11604_bib11","doi-asserted-by":"crossref","first-page":"7754","DOI":"10.1128\/jvi.69.12.7754-7758.1995","volume":"69","author":"Priola","year":"1995","journal-title":"J. Virol."},{"key":"10.1074\/jbc.272.17.11604_bib12","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/370471a0","volume":"370","author":"Kocisko","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.272.17.11604_bib13","doi-asserted-by":"crossref","first-page":"11160","DOI":"10.1073\/pnas.92.24.11160","volume":"92","author":"Kaneko","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.272.17.11604_bib14","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/0092-8674(93)90635-4","volume":"73","author":"Jarrett","year":"1993","journal-title":"Cell"},{"key":"10.1074\/jbc.272.17.11604_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02778003","volume":"8","author":"Gajdusek","year":"1994","journal-title":"Mol. Neurobiol."},{"key":"10.1074\/jbc.272.17.11604_bib16","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/1074-5521(95)90087-X","volume":"2","author":"Caughey","year":"1995","journal-title":"Chem. Biol."},{"key":"10.1074\/jbc.272.17.11604_bib17","first-page":"49","volume":"207","author":"Huang","year":"1996","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1074\/jbc.272.17.11604_bib18","doi-asserted-by":"crossref","first-page":"18217","DOI":"10.1016\/S0021-9258(18)55257-1","volume":"266","author":"Caughey","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.17.11604_bib19","doi-asserted-by":"crossref","first-page":"16188","DOI":"10.1016\/S0021-9258(18)41985-0","volume":"267","author":"Borchelt","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.17.11604_bib20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1083\/jcb.129.1.121","volume":"129","author":"Taraboulos","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.272.17.11604_bib21","doi-asserted-by":"crossref","first-page":"14945","DOI":"10.1073\/pnas.93.25.14945","volume":"93","author":"Vey","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.272.17.11604_bib22","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/381571a0","volume":"381","author":"Hartl","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.272.17.11604_bib23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0092-8674(95)90236-8","volume":"83","author":"Telling","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.272.17.11604_bib24","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1128\/jvi.62.5.1558-1564.1988","volume":"62","author":"Butler","year":"1988","journal-title":"J. Virol."},{"key":"10.1074\/jbc.272.17.11604_bib25","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1128\/jvi.62.8.2845-2849.1988","volume":"62","author":"Race","year":"1988","journal-title":"J. Virol."},{"key":"10.1074\/jbc.272.17.11604_bib26","doi-asserted-by":"crossref","first-page":"24589","DOI":"10.1074\/jbc.270.41.24589","volume":"270","author":"Lehmann","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.17.11604_bib27","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1074\/jbc.271.3.1633","volume":"271","author":"Lehmann","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.17.11604_bib28","doi-asserted-by":"crossref","first-page":"5610","DOI":"10.1073\/pnas.93.11.5610","volume":"93","author":"Lehmann","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.272.17.11604_bib29","doi-asserted-by":"crossref","first-page":"12661","DOI":"10.1074\/jbc.271.21.12661","volume":"271","author":"Petersen","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.17.11604_bib30","doi-asserted-by":"crossref","first-page":"14793","DOI":"10.1074\/jbc.270.24.14793","volume":"270","author":"Shyng","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.17.11604_bib31","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1128\/jvi.61.12.3688-3693.1987","volume":"61","author":"Kascsak","year":"1987","journal-title":"J. Virol."},{"key":"10.1074\/jbc.272.17.11604_bib32","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1021\/bi00055a003","volume":"32","author":"Harris","year":"1993","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.272.17.11604_bib33","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/S0021-9258(19)69848-0","volume":"256","author":"Bordier","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.17.11604_bib34","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0092-8674(89)90685-5","volume":"56","author":"Lippincott-Schwartz","year":"1989","journal-title":"Cell"},{"key":"10.1074\/jbc.272.17.11604_bib35","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0092-8674(83)90154-X","volume":"34","author":"Matlin","year":"1983","journal-title":"Cell"},{"key":"10.1074\/jbc.272.17.11604_bib36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0091-679X(08)61174-7","volume":"32","author":"Kuismanen","year":"1989","journal-title":"Methods Cell Biol."},{"key":"10.1074\/jbc.272.17.11604_bib37","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.1021\/bi00370a003","volume":"25","author":"Medof","year":"1986","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.272.17.11604_bib38","series-title":"Post-translational Modification of Proteins by Lipids","first-page":"40","author":"Davitz","year":"1988"},{"key":"10.1074\/jbc.272.17.11604_bib39","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0955-0674(93)90135-D","volume":"5","author":"Anderson","year":"1993","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.272.17.11604_bib40","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0962-8924(94)90114-7","volume":"4","author":"Lisanti","year":"1994","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.272.17.11604_bib41","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nm0196-59","volume":"2","author":"Gabizon","year":"1996","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.272.17.11604_bib42","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1074\/jbc.270.7.3299","volume":"270","author":"Priola","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.17.11604_bib43","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/383685a0","volume":"383","author":"Collinge","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.272.17.11604_bib44","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1126\/science.274.5295.2079","volume":"274","author":"Telling","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.272.17.11604_bib45","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/ana.410390613","volume":"39","author":"Parchi","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1074\/jbc.272.17.11604_bib46","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0962-8924(92)90101-R","volume":"2","author":"Amara","year":"1992","journal-title":"Trends Cell Biol."},{"key":"10.1074\/jbc.272.17.11604_bib47","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1073\/pnas.92.7.2944","volume":"92","author":"Tatzelt","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.272.17.11604_bib48","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1126\/science.7754373","volume":"268","author":"Chernoff","year":"1995","journal-title":"Science"},{"key":"10.1074\/jbc.272.17.11604_bib49","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1091\/mbc.3.8.851","volume":"3","author":"Taraboulos","year":"1992","journal-title":"Mol. Biol. Cell"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818406801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818406801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.272.17.11604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T07:11:45Z","timestamp":1641021105000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818406801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":49,"journal-issue":{"issue":"17","published-print":{"date-parts":[[1997,4]]}},"alternative-id":["S0021925818406801"],"URL":"https:\/\/doi.org\/10.1074\/jbc.272.17.11604","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1997,4]]}}}