{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:36:35Z","timestamp":1791408995212,"version":"4.3.3"},"reference-count":41,"publisher":"Elsevier BV","issue":"28","license":[{"start":{"date-parts":[[1997,7,1]],"date-time":"1997-07-01T00:00:00Z","timestamp":867715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"vor","delay-in-days":8502,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1997,7]]},"DOI":"10.1074\/jbc.272.28.17269","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:13:47Z","timestamp":1027696427000},"page":"17269-17275","source":"Crossref","is-referenced-by-count":362,"title":["Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades"],"prefix":"10.1016","volume":"272","author":[{"given":"Johan","family":"Deprez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Vertommen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario R.","family":"Alessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Hue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Rider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.272.28.17269_bib1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1042\/bj2450313","volume":"245","author":"Hue","year":"1987","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.272.28.17269_bib2","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1016\/S0021-9258(18)34722-7","volume":"257","author":"Hue","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.28.17269_bib3","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0014-5793(84)81223-5","volume":"176","author":"Rider","year":"1984","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.272.28.17269_bib4","doi-asserted-by":"crossref","first-page":"13274","DOI":"10.1016\/S0021-9258(19)38648-X","volume":"268","author":"Depre","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.28.17269_bib5","doi-asserted-by":"crossref","first-page":"22289","DOI":"10.1074\/jbc.271.37.22289","volume":"271","author":"Lefebvre","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.28.17269_bib6","first-page":"E375","volume":"270","author":"Saltiel","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.272.28.17269_bib7","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1432-1033.1991.tb16176.x","volume":"199","author":"Lavoinne","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.272.28.17269_bib8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/370071a0","volume":"370","author":"Chung","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.272.28.17269_bib9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/376599a0","volume":"376","author":"Burgering","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.272.28.17269_bib10","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1432-1033.1991.tb16305.x","volume":"210","author":"Coffer","year":"1991","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.272.28.17269_bib11","first-page":"244","volume":"254","author":"Belacossa","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.272.28.17269_bib12","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1073\/pnas.88.10.4171","volume":"88","author":"Jones","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.272.28.17269_bib13","series-title":"Fructose 2,6-Bisphosphate","first-page":"173","author":"Hue","year":"1990"},{"key":"10.1074\/jbc.272.28.17269_bib14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0014-5793(91)81009-W","volume":"288","author":"Darville","year":"1991","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.272.28.17269_bib15","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1042\/bj2850405","volume":"285","author":"Rider","year":"1992","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.272.28.17269_bib16","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0006-291X(05)81088-5","volume":"180","author":"Sakata","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.272.28.17269_bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0014-5793(92)81315-D","volume":"310","author":"Rider","year":"1992","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.272.28.17269_bib18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0014-5793(93)80898-5","volume":"330","author":"Vidal","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.272.28.17269_bib19","doi-asserted-by":"crossref","first-page":"8876","DOI":"10.1021\/bi00027a040","volume":"34","author":"Chikri","year":"1995","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.272.28.17269_bib20","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1432-1033.1993.tb17696.x","volume":"212","author":"Sutherland","year":"1993","journal-title":"Eur J. Biochem."},{"key":"10.1074\/jbc.272.28.17269_bib21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0014-5793(95)01170-J","volume":"375","author":"Leighton","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.272.28.17269_bib22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0960-9822(06)00122-9","volume":"7","author":"Alessi","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.272.28.17269_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0076-6879(83)99039-0","volume":"99","author":"Reimann","year":"1983","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.272.28.17269_bib24","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/0076-6879(88)59039-0","volume":"159","author":"Cohen","year":"1988","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.272.28.17269_bib25","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1073\/pnas.83.6.1613","volume":"83","author":"Scott","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.272.28.17269_bib26","doi-asserted-by":"crossref","first-page":"17875","DOI":"10.1074\/jbc.271.30.17875","volume":"271","author":"Vertommen","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.28.17269_bib27","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1074\/jbc.272.28.17269_bib28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0076-6879(83)99034-1","volume":"99","author":"Roskoski","year":"1983","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.272.28.17269_bib29","doi-asserted-by":"crossref","first-page":"15277","DOI":"10.1016\/S0021-9258(18)82466-8","volume":"268","author":"Crepin","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.28.17269_bib30","doi-asserted-by":"crossref","first-page":"13825","DOI":"10.1016\/S0021-9258(18)80075-8","volume":"264","author":"Price","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.28.17269_bib31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/378785a0","volume":"378","author":"Cross","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.272.28.17269_bib32","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1002\/j.1460-2075.1992.tb05492.x","volume":"11","author":"Stokoe","year":"1992","journal-title":"EMBO J."},{"key":"10.1074\/jbc.272.28.17269_bib33","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.272.28.17269_bib34","series-title":"Sequencing of Proteins and Peptides","first-page":"140","author":"Allen","year":"1989"},{"key":"10.1074\/jbc.272.28.17269_bib35","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1021\/bi00008a020","volume":"34","author":"Abe","year":"1995","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.272.28.17269_bib36","series-title":"Methods in Protein Structure Analysis","first-page":"15","author":"Gevaert","year":"1995"},{"key":"10.1074\/jbc.272.28.17269_bib37","doi-asserted-by":"crossref","first-page":"16796","DOI":"10.1016\/S0021-9258(18)37461-1","volume":"263","author":"Kitamura","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.28.17269_bib38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1042\/bj2400057","volume":"240","author":"Rider","year":"1986","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.272.28.17269_bib39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/bj2960015","volume":"296","author":"Sutherland","year":"1993","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.272.28.17269_bib40","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1016\/S0021-9258(19)50696-2","volume":"267","author":"Flotow","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.28.17269_bib41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0014-5793(96)01370-1","volume":"399","author":"Alessi","year":"1996","journal-title":"FEBS Lett."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818391919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818391919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.272.28.17269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T17:21:04Z","timestamp":1639675264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818391919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,7]]},"references-count":41,"journal-issue":{"issue":"28","published-print":{"date-parts":[[1997,7]]}},"alternative-id":["S0021925818391919"],"URL":"https:\/\/doi.org\/10.1074\/jbc.272.28.17269","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1997,7]]}}}