{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T21:36:39Z","timestamp":1783373799968,"version":"3.54.6"},"reference-count":45,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[1997,2,1]],"date-time":"1997-02-01T00:00:00Z","timestamp":854755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T00:00:00Z","timestamp":1602201600000},"content-version":"vor","delay-in-days":8651,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1997,2]]},"DOI":"10.1074\/jbc.272.8.5256","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:14:15Z","timestamp":1027696455000},"page":"5256-5260","source":"Crossref","is-referenced-by-count":63,"title":["Functional Characterization of a Distinct Ryanodine Receptor Mutation in Human Malignant Hyperthermia-susceptible Muscle"],"prefix":"10.1016","volume":"272","author":[{"given":"Michael","family":"Richter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Schleithoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Deufel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lehmann-Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annegret","family":"Herrmann-Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.272.8.5256_bib1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1126\/science.1862346","volume":"253","author":"Fujii","year":"1991","journal-title":"Science"},{"key":"10.1074\/jbc.272.8.5256_bib2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/343559a0","volume":"343","author":"MacLennan","year":"1990","journal-title":"Nature"},{"key":"10.1074\/jbc.272.8.5256_bib3","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/343562a0","volume":"343","author":"McCarthy","year":"1990","journal-title":"Nature"},{"key":"10.1074\/jbc.272.8.5256_bib4","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/hmg\/3.6.969","volume":"3","author":"Iles","year":"1994","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.272.8.5256_bib5","first-page":"684","volume":"56","author":"Sudbrak","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1074\/jbc.272.8.5256_bib6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00019052-199510000-00013","volume":"8","author":"MacLennan","year":"1995","journal-title":"Curr. Opin. Neurol."},{"key":"10.1074\/jbc.272.8.5256_bib7","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/bja\/56.11.1267","volume":"56","author":"European Malignant Hyperthermia Group","year":"1984","journal-title":"Br. J. Anaesth."},{"key":"10.1074\/jbc.272.8.5256_bib8","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1139\/o90-177","volume":"68","author":"Fletcher","year":"1990","journal-title":"Biochem. Cell Biol."},{"key":"10.1074\/jbc.272.8.5256_bib9","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0006-3495(91)82323-2","volume":"59","author":"Fill","year":"1991","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.272.8.5256_bib10","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/0024-3205(91)90060-O","volume":"49","author":"Fletcher","year":"1991","journal-title":"Life Sci."},{"key":"10.1074\/jbc.272.8.5256_bib11","doi-asserted-by":"crossref","first-page":"C237","DOI":"10.1152\/ajpcell.1991.261.2.C237","volume":"30","author":"Valdivia","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.272.8.5256_bib12","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/00000542-199204000-00016","volume":"76","author":"Nelson","year":"1992","journal-title":"Anesthesiology"},{"key":"10.1074\/jbc.272.8.5256_bib13","first-page":"763","volume":"29","author":"Fletcher","year":"1993","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1074\/jbc.272.8.5256_bib14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1006\/geno.1996.0238","volume":"34","author":"Phillips","year":"1996","journal-title":"Genomics"},{"key":"10.1074\/jbc.272.8.5256_bib15","author":"Herrmann-Frank","year":"1997","journal-title":"Am. J. Anesthesiol."},{"key":"10.1074\/jbc.272.8.5256_bib16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0006-2952(96)00175-X","volume":"52","author":"Herrmann-Frank","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1074\/jbc.272.8.5256_bib17","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.8.5256_bib18","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/0076-6879(88)57093-3","volume":"157","author":"Fabiato","year":"1988","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.272.8.5256_bib19","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1093\/hmg\/3.10.1855","volume":"3","author":"Keating","year":"1994","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.272.8.5256_bib20","first-page":"232","volume":"31","author":"Pessah","year":"1986","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.272.8.5256_bib21","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0005-2736(88)90106-X","volume":"939","author":"Michalak","year":"1988","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.272.8.5256_bib22","first-page":"735","volume":"37","author":"Chu","year":"1990","journal-title":"Mol. Pharmacol."},{"key":"10.1074\/jbc.272.8.5256_bib23","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1152\/physrev.1996.76.2.537","volume":"76","author":"Mickelson","year":"1996","journal-title":"Physiol. Rev."},{"key":"10.1074\/jbc.272.8.5256_bib24","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1021\/bi00349a034","volume":"25","author":"Meissner","year":"1986","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.272.8.5256_bib25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0005-2736(88)90124-1","volume":"938","author":"Plank","year":"1988","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.272.8.5256_bib26","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1161\/01.RES.64.2.352","volume":"64","author":"Smith","year":"1989","journal-title":"Circ. Res."},{"key":"10.1074\/jbc.272.8.5256_bib27","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0143-4160(94)90070-1","volume":"15","author":"Fuentes","year":"1994","journal-title":"Cell Calcium"},{"key":"10.1074\/jbc.272.8.5256_bib28","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1006\/bbrc.1995.2238","volume":"213","author":"Buratti","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.272.8.5256_bib29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0006-3495(95)79880-0","volume":"69","author":"Tripathy","year":"1995","journal-title":"Biophys. J."},{"key":"10.1074\/jbc.272.8.5256_bib30","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1042\/bj3190421","volume":"319","author":"O'Driscoll","year":"1996","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.272.8.5256_bib31","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1042\/bj3010661","volume":"301","author":"Treves","year":"1994","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.272.8.5256_bib32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0304-4165(95)00131-X","volume":"1289","author":"Herrmann-Frank","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1074\/jbc.272.8.5256_bib33","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1097\/00000542-199606000-00014","volume":"84","author":"Tegazzin","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1074\/jbc.272.8.5256_bib34","doi-asserted-by":"crossref","first-page":"C1485","DOI":"10.1152\/ajpcell.1994.266.6.C1485","volume":"266","author":"Coronado","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.272.8.5256_bib35","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.ph.56.030194.002413","volume":"56","author":"Meissner","year":"1994","journal-title":"Annu. Rev. Physiol."},{"key":"10.1074\/jbc.272.8.5256_bib36","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/339439a0","volume":"339","author":"Takeshima","year":"1989","journal-title":"Nature"},{"key":"10.1074\/jbc.272.8.5256_bib37","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1016\/S0021-9258(19)39968-5","volume":"265","author":"Zorzato","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.8.5256_bib38","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/ng0993-46","volume":"5","author":"Zhang","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.272.8.5256_bib39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/ng0993-51","volume":"5","author":"Quane","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1074\/jbc.272.8.5256_bib40","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/geno.1994.1483","volume":"23","author":"Quane","year":"1994","journal-title":"Genomics"},{"key":"10.1074\/jbc.272.8.5256_bib41","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1093\/hmg\/3.12.2181","volume":"3","author":"Phillips","year":"1994","journal-title":"Hum. Mol. Genet."},{"key":"10.1074\/jbc.272.8.5256_bib42","doi-asserted-by":"crossref","first-page":"C125","DOI":"10.1152\/ajpcell.1993.264.1.C125","volume":"264","author":"Shomer","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1074\/jbc.272.8.5256_bib43","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1002\/mus.880181013","volume":"18","author":"Shomer","year":"1995","journal-title":"Muscle & Nerve"},{"key":"10.1074\/jbc.272.8.5256_bib44","doi-asserted-by":"crossref","first-page":"22698","DOI":"10.1016\/S0021-9258(17)31702-7","volume":"269","author":"Chen","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.272.8.5256_bib45","doi-asserted-by":"crossref","first-page":"9078","DOI":"10.1021\/bi00197a008","volume":"33","author":"Menegazzi","year":"1994","journal-title":"Biochemistry"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819793685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819793685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.272.8.5256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T22:58:38Z","timestamp":1641250718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819793685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,2]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1997,2]]}},"alternative-id":["S0021925819793685"],"URL":"https:\/\/doi.org\/10.1074\/jbc.272.8.5256","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1997,2]]}}}