{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T03:28:35Z","timestamp":1772594915811,"version":"3.50.1"},"reference-count":67,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T00:00:00Z","timestamp":1602633600000},"content-version":"vor","delay-in-days":8263,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1998,3]]},"DOI":"10.1074\/jbc.273.11.6030","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:56:47Z","timestamp":1027695407000},"page":"6030-6040","source":"Crossref","is-referenced-by-count":103,"title":["3-Amino-5-hydroxybenzoic Acid Synthase, the Terminal Enzyme in the Formation of the Precursor of mC7N Units in Rifamycin and Related Antibiotics"],"prefix":"10.1016","volume":"273","author":[{"given":"Chun-Gyu","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tin-Wein","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig B.","family":"Fryhle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Handa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz G.","family":"Floss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.273.11.6030_bib1","first-page":"79","volume":"39","author":"Ghisalba","year":"1985","journal-title":"Chimia"},{"key":"10.1074\/jbc.273.11.6030_bib2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ange.19891010205","volume":"101","author":"Floss","year":"1989","journal-title":"Angew. Chem."},{"key":"10.1074\/jbc.273.11.6030_bib3","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1039\/c39800000768","author":"Kibby","year":"1980","journal-title":"J. Chem. Soc. Chem. Commun."},{"key":"10.1074\/jbc.273.11.6030_bib4","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1039\/c39800001277","author":"Anderson","year":"1980","journal-title":"J. Chem. Soc. Chem. Commun."},{"key":"10.1074\/jbc.273.11.6030_bib5","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.7164\/antibiotics.35.1415","volume":"35","author":"Hatano","year":"1982","journal-title":"J. Antibiot."},{"key":"10.1074\/jbc.273.11.6030_bib6","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1039\/c39890000311","author":"Anderson","year":"1989","journal-title":"J. Chem. Soc. Chem. Commun."},{"key":"10.1074\/jbc.273.11.6030_bib7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.7164\/antibiotics.34.64","volume":"34","author":"Ghisalba","year":"1981","journal-title":"J. Antibiot."},{"key":"10.1074\/jbc.273.11.6030_bib8","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1021\/ja00038a090","volume":"114","author":"Kim","year":"1992","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.273.11.6030_bib9","doi-asserted-by":"crossref","first-page":"7486","DOI":"10.1021\/ja9601292","volume":"118","author":"Kim","year":"1996","journal-title":"J. Am Chem. Soc."},{"key":"10.1074\/jbc.273.11.6030_bib10","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/nar\/12.1Part1.387","volume":"12","author":"Devereux","year":"1984","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.273.11.6030_bib11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0378-1119(85)90001-0","volume":"35","author":"Lydiate","year":"1985","journal-title":"Gene (Amst.)"},{"key":"10.1074\/jbc.273.11.6030_bib12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1574-6968.1997.tb12561.x","volume":"151","author":"Mazy-Servais","year":"1997","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1074\/jbc.273.11.6030_bib13","first-page":"431","volume":"4","author":"Lancini","year":"1986"},{"key":"10.1074\/jbc.273.11.6030_bib14","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/rcm.1290061115","volume":"6","author":"Ferrige","year":"1992","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1074\/jbc.273.11.6030_bib15","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/rcm.1290061211","volume":"6","author":"Ferrige","year":"1992","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1074\/jbc.273.11.6030_bib16","first-page":"169","volume":"15","author":"Gygax","year":"1982","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1074\/jbc.273.11.6030_bib17","doi-asserted-by":"crossref","first-page":"10035","DOI":"10.1016\/S0021-9258(18)61070-1","volume":"262","author":"Matsudaira","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.11.6030_bib18","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0003-2697(82)90056-2","volume":"124","author":"Gershoni","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.273.11.6030_bib19","first-page":"787","volume":"8","author":"Simpson","year":"1984","journal-title":"Biochem. Int."},{"key":"10.1074\/jbc.273.11.6030_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0021-9673(01)93856-7","volume":"476","author":"Choli","year":"1989","journal-title":"J. Chromatog."},{"key":"10.1074\/jbc.273.11.6030_bib21","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0076-6879(83)91032-7","volume":"91","author":"Hermodson","year":"1983","journal-title":"Methods Enzymol."},{"key":"10.1074\/jbc.273.11.6030_bib22","doi-asserted-by":"crossref","first-page":"E357","DOI":"10.1016\/0378-1119(86)90122-8","volume":"41","author":"Bibb","year":"1985","journal-title":"Gene (Amst.)"},{"key":"10.1074\/jbc.273.11.6030_bib23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0378-1119(92)90627-2","volume":"116","author":"Bierman","year":"1992","journal-title":"Gene (Amst.)"},{"key":"10.1074\/jbc.273.11.6030_bib24","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/nar\/12.1Part2.539","volume":"12","author":"Gribskov","year":"1984","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.273.11.6030_bib25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF00331128","volume":"187","author":"Bibb","year":"1982","journal-title":"Mol. Gen. Genet."},{"key":"10.1074\/jbc.273.11.6030_bib26","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1093\/nar\/12.10.4411","volume":"12","author":"Brendel","year":"1984","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.273.11.6030_bib27","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/nar\/12.1Part1.387","volume":"12","author":"Devereux","year":"1984","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.273.11.6030_bib28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"10.1074\/jbc.273.11.6030_bib29","doi-asserted-by":"crossref","first-page":"6993","DOI":"10.1021\/ja00068a075","volume":"115","author":"Thorson","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.273.11.6030_bib30","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s002030050475","volume":"168","author":"Ahlert","year":"1997","journal-title":"Arch. Microbiol."},{"key":"10.1074\/jbc.273.11.6030_bib31","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1365-2958.1996.354877.x","volume":"19","author":"Allen","year":"1996","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.273.11.6030_bib32","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1128\/jb.172.1.411-418.1990","volume":"172","author":"Tagaki","year":"1990","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.273.11.6030_bib33","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1111\/j.1365-2958.1989.tb00123.x","volume":"3","author":"Dhillon","year":"1989","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.273.11.6030_bib34","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1365-2958.1994.tb00428.x","volume":"13","author":"Merson-Davies","year":"1994","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.273.11.6030_bib35","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1128\/jb.174.1.144-154.1992","volume":"174","author":"Stutzman-Engwall","year":"1992","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.273.11.6030_bib36","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1074\/jbc.271.3.1579","volume":"271","author":"Tercero","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.11.6030_bib37","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1128\/jb.179.8.2740-2747.1997","volume":"179","author":"Stroeher","year":"1997","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.273.11.6030_bib38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0378-1119(95)00459-J","volume":"164","author":"Bastin","year":"1995","journal-title":"Gene (Amst.)"},{"key":"10.1074\/jbc.273.11.6030_bib39","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1128\/jb.176.17.5483-5493.1994","volume":"176","author":"Thorson","year":"1994","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.273.11.6030_bib40","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1128\/jb.175.5.1412-1422.1993","volume":"175","author":"Kessler","year":"1993","journal-title":"J. Bacteriol."},{"key":"10.1074\/jbc.273.11.6030_bib41","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1365-2958.1991.tb00741.x","volume":"5","author":"Jiang","year":"1991","journal-title":"Mol. Microbiol."},{"key":"10.1074\/jbc.273.11.6030_bib42","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/pro.5560030418","volume":"3","author":"Pascarella","year":"1994","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.273.11.6030_bib43","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.mi.48.100194.001255","volume":"48","author":"Liu","year":"1994","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1074\/jbc.273.11.6030_bib44","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/07388554409079835","volume":"14","author":"Piepersberg","year":"1994","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1074\/jbc.273.11.6030_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BFb0119234","volume":"188","author":"Kirschning","year":"1997","journal-title":"Top. Curr. Chem."},{"key":"10.1074\/jbc.273.11.6030_bib46","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1021\/bi00122a034","volume":"31","author":"Weigel","year":"1992","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.273.11.6030_bib47","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1021\/bi00122a035","volume":"31","author":"Weigel","year":"1992","journal-title":"Biochemistry"},{"key":"10.1074\/jbc.273.11.6030_bib48","doi-asserted-by":"crossref","first-page":"12177","DOI":"10.1021\/ja00078a071","volume":"115","author":"Thorson","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.273.11.6030_bib49","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1432-1033.1993.tb17953.x","volume":"214","author":"Mehta","year":"1993","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.273.11.6030_bib50","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/j.1432-1033.1994.tb18577.x","volume":"219","author":"Alexander","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.273.11.6030_bib51","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/pro.5560040705","volume":"4","author":"Grishin","year":"1995","journal-title":"Protein Sci."},{"key":"10.1074\/jbc.273.11.6030_bib52","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1098\/rspb.1988.0067","volume":"235","author":"Hopwood","year":"1988","journal-title":"Proc. R. Soc. London B"},{"key":"10.1074\/jbc.273.11.6030_bib53","year":"1986"},{"key":"10.1074\/jbc.273.11.6030_bib54","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1016\/S0021-9258(19)73791-0","volume":"237","author":"Schirch","year":"1962","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.11.6030_bib55","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1432-1033.1986.tb09653.x","volume":"157","author":"Perkins","year":"1986","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.273.11.6030_bib56","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0040-4039(00)77904-4","author":"Kobayashi","year":"1976","journal-title":"Tetrahedron Lett."},{"key":"10.1074\/jbc.273.11.6030_bib57","series-title":"Transaminases","first-page":"266","author":"Soper","year":"1985"},{"key":"10.1074\/jbc.273.11.6030_bib58","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1021\/ja00373a059","volume":"104","author":"Rinehart","year":"1982","journal-title":"J. Am. Chem. Soc."},{"key":"10.1074\/jbc.273.11.6030_bib59","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1016\/0040-4020(78)80222-1","volume":"34","author":"Ganem","year":"1978","journal-title":"Tetrahedron"},{"key":"10.1074\/jbc.273.11.6030_bib60","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1039\/a607122h","author":"Handa","year":"1997","journal-title":"J. Chem. Soc. Chem. Commun."},{"key":"10.1074\/jbc.273.11.6030_bib61","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1002\/cber.19560890908","volume":"89","author":"Grewe","year":"1956","journal-title":"Chem. Ber."},{"key":"10.1074\/jbc.273.11.6030_bib62","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1039\/c29710000765","author":"Scharf","year":"1971","journal-title":"J. Chem. Soc. Chem. Commun."},{"key":"10.1074\/jbc.273.11.6030_bib63","unstructured":"Kim, C.-G., Biosynthesis of 3-Amino-5-hydroxybenzoic Acid, the Precursor of the MGN-unit in Ansamycin Antibiotics, Ph.D. dissertation, 1994, University of Washington, Seattle."},{"key":"10.1074\/jbc.273.11.6030_bib64","first-page":"33","volume":"7","author":"Davis","year":"1972"},{"key":"10.1074\/jbc.273.11.6030_bib65","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1021\/ar50156a004","volume":"13","author":"Vederas","year":"1980","journal-title":"Acc. Chem. Res."},{"key":"10.1074\/jbc.273.11.6030_bib66","series-title":"Stereochemistry","first-page":"161","author":"Floss","year":"1982"},{"key":"10.1074\/jbc.273.11.6030_bib67","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.1365-2958.1996.1351503.x","volume":"22","author":"Burrows","year":"1996","journal-title":"Mol. Microbiol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818677063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818677063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.273.11.6030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T23:45:08Z","timestamp":1641080708000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818677063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":67,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["S0021925818677063"],"URL":"https:\/\/doi.org\/10.1074\/jbc.273.11.6030","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}