{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:38:16Z","timestamp":1788975496165,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","issue":"14","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T00:00:00Z","timestamp":1602374400000},"content-version":"vor","delay-in-days":8229,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1998,4]]},"DOI":"10.1074\/jbc.273.14.8217","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:04:43Z","timestamp":1027695883000},"page":"8217-8224","source":"Crossref","is-referenced-by-count":107,"title":["Prevention of Mitochondrial Injury by Manganese Superoxide Dismutase Reveals a Primary Mechanism for Alkaline-induced Cell Death"],"prefix":"10.1016","volume":"273","author":[{"given":"Hideyuki J.","family":"Majima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry D.","family":"Oberley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutoshi","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Mattson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu-Chuan","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke I.","family":"Szweda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daret K.St.","family":"Clair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.273.14.8217_bib1","series-title":"Clinical Physiology of Acid-Base and Electrolyte Disorders","first-page":"550","author":"Rose","year":"1994"},{"key":"10.1074\/jbc.273.14.8217_bib2","first-page":"543","volume":"2","author":"Halliwell","year":"1989","journal-title":"Free Radicals Biol. Med."},{"key":"10.1074\/jbc.273.14.8217_bib3","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1042\/bst0210330","volume":"21","author":"Beckman","year":"1993","journal-title":"Biochem. Soc. Trans."},{"key":"10.1074\/jbc.273.14.8217_bib4","series-title":"Superoxide Dismutase","author":"Oberley","year":"1982"},{"key":"10.1074\/jbc.273.14.8217_bib5","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1152\/physrev.1979.59.3.527","volume":"59","author":"Chance","year":"1979","journal-title":"Physiol Rev."},{"key":"10.1074\/jbc.273.14.8217_bib6","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1006\/abbi.1995.1122","volume":"316","author":"Giulivi","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.273.14.8217_bib7","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1016\/S0021-9258(18)49961-9","volume":"266","author":"Pettepher","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.14.8217_bib8","doi-asserted-by":"crossref","first-page":"12248","DOI":"10.1073\/pnas.91.25.12248","volume":"91","author":"Gardner","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.273.14.8217_bib9","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/371346a0","volume":"371","author":"Lazebnik","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.273.14.8217_bib10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/0092-8674(95)90422-0","volume":"82","author":"Martin","year":"1995","journal-title":"Cell"},{"key":"10.1074\/jbc.273.14.8217_bib11","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1126\/science.275.5303.1129","volume":"275","author":"Yang","year":"1997","journal-title":"Science"},{"key":"10.1074\/jbc.273.14.8217_bib12","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1172\/JCI119339","volume":"99","author":"Higuchi","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.273.14.8217_bib13","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1084\/jem.183.4.1533","volume":"183","author":"Zamzami","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.273.14.8217_bib14","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1016\/S0021-9258(19)43735-6","volume":"248","author":"Weisiger","year":"1973","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.14.8217_bib15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/j.1460-2075.1986.tb04256.x","volume":"5","author":"Carlioz","year":"1986","journal-title":"EMBO J."},{"key":"10.1074\/jbc.273.14.8217_bib16","doi-asserted-by":"crossref","first-page":"8268","DOI":"10.1073\/pnas.83.21.8268","volume":"83","author":"Farr","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.273.14.8217_bib17","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1073\/pnas.83.11.3820","volume":"83","author":"van Loon","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.273.14.8217_bib18","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ng1295-376","volume":"11","author":"Li","year":"1995","journal-title":"Nature Genet."},{"key":"10.1074\/jbc.273.14.8217_bib19","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1126\/science.3263703","volume":"242","author":"Wong","year":"1988","journal-title":"Science"},{"key":"10.1074\/jbc.273.14.8217_bib20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0014-5793(91)81186-C","volume":"293","author":"St. Clair","year":"1991","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.273.14.8217_bib21","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0092-8674(89)90944-6","volume":"58","author":"Wong","year":"1989","journal-title":"Cell"},{"key":"10.1074\/jbc.273.14.8217_bib22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1096\/fasebj.7.2.8440412","volume":"7","author":"Hirose","year":"1993","journal-title":"FASEB J."},{"key":"10.1074\/jbc.273.14.8217_bib23","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/mc.2940060404","volume":"6","author":"St. Clair","year":"1992","journal-title":"Mol. Carcinog."},{"key":"10.1074\/jbc.273.14.8217_bib24","doi-asserted-by":"crossref","first-page":"23937","DOI":"10.1016\/S0021-9258(18)35927-1","volume":"267","author":"Wispe","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.14.8217_bib25","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1172\/JCI118909","volume":"98","author":"Yen","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.273.14.8217_bib26","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/0360-3016(92)90802-O","volume":"22","author":"Majima","year":"1992","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1074\/jbc.273.14.8217_bib27","first-page":"4261","volume":"54","author":"Safford","year":"1994","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.273.14.8217_bib28","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0003-2697(71)90370-8","volume":"44","author":"Beauchamp","year":"1971","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.273.14.8217_bib29","first-page":"32","volume":"41","author":"Darzynkiewicz","year":"1994","journal-title":"Methods Cell Biol."},{"key":"10.1074\/jbc.273.14.8217_bib30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1083\/jcb.95.1.189","volume":"95","author":"Rink","year":"1982","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.273.14.8217_bib31","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/cyto.990110509","volume":"11","author":"Wang","year":"1990","journal-title":"Cytometry"},{"key":"10.1074\/jbc.273.14.8217_bib32","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1113\/jphysiol.1988.sp017211","volume":"402","author":"Aalkjaer","year":"1988","journal-title":"J. Physiol."},{"key":"10.1074\/jbc.273.14.8217_bib33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0091-679X(08)61930-5","volume":"46","author":"Mattson","year":"1995","journal-title":"Methods Cell Biol."},{"key":"10.1074\/jbc.273.14.8217_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/exnr.1994.1107","volume":"128","author":"Goodman","year":"1994","journal-title":"Exp. Neurol."},{"key":"10.1074\/jbc.273.14.8217_bib35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/abbi.1995.0036","volume":"324","author":"Uchida","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.273.14.8217_bib36","doi-asserted-by":"crossref","first-page":"8742","DOI":"10.1073\/pnas.90.18.8742","volume":"90","author":"Uchida","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.273.14.8217_bib37","series-title":"Statistical Principles of Research Design and Analysis","first-page":"686","author":"Kuhl","year":"1994"},{"key":"10.1074\/jbc.273.14.8217_bib38","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1042\/bj2670453","volume":"267","author":"Spitz","year":"1990","journal-title":"Biochem. J."},{"key":"10.1074\/jbc.273.14.8217_bib39","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1523\/JNEUROSCI.17-13-05089.1997","volume":"17","author":"Kruman","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.273.14.8217_bib40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0891-5849(91)90192-6","volume":"11","author":"Esterbauer","year":"1991","journal-title":"Free Radical Biol. & Med."},{"key":"10.1074\/jbc.273.14.8217_bib41","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1084\/jem.182.2.367","volume":"182","author":"Zamzami","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.273.14.8217_bib42","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3109\/10715769509065273","volume":"23","author":"Bolwell","year":"1994","journal-title":"Free Radical Res."},{"key":"10.1074\/jbc.273.14.8217_bib43","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1152\/jappl.1970.28.1.4","volume":"28","author":"Cain","year":"1970","journal-title":"J. Appl. Physiol."},{"key":"10.1074\/jbc.273.14.8217_bib44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1152\/jappl.1970.28.1.8","volume":"28","author":"Karetzky","year":"1970","journal-title":"J. Appl. Physiol."},{"key":"10.1074\/jbc.273.14.8217_bib45","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00000542-197301000-00014","volume":"38","author":"Khambatta","year":"1973","journal-title":"Anesthesiology"},{"key":"10.1074\/jbc.273.14.8217_bib46","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/0952-8180(92)90219-Q","volume":"4","author":"Slater","year":"1992","journal-title":"J. Clin. Anesth."},{"key":"10.1074\/jbc.273.14.8217_bib47","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1126\/science.210504","volume":"201","author":"Fridovich","year":"1978","journal-title":"Science"},{"key":"10.1074\/jbc.273.14.8217_bib48","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1172\/JCI118100","volume":"96","author":"Guidot","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.273.14.8217_bib49","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1083\/jcb.136.4.833","volume":"136","author":"Babcock","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.273.14.8217_bib50","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1146\/annurev.pa.32.040192.002313","volume":"32","author":"Nicotera","year":"1992","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1074\/jbc.273.14.8217_bib51","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1096\/fasebj.3.13.2806779","volume":"3","author":"Friedl","year":"1989","journal-title":"FASEB J."},{"key":"10.1074\/jbc.273.14.8217_bib52","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/374814a0","volume":"374","author":"Jacobson","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.273.14.8217_bib53","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0003-9861(87)90082-8","volume":"254","author":"Oberley","year":"1987","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1074\/jbc.273.14.8217_bib54","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1016\/S0021-9258(19)77964-2","volume":"263","author":"Krall","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.273.14.8217_bib55","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0891-5849(90)90155-C","volume":"8","author":"Sinha","year":"1990","journal-title":"Free Radical Biol. Med."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818525485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925818525485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.273.14.8217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T18:04:12Z","timestamp":1639677852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925818525485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4]]},"references-count":55,"journal-issue":{"issue":"14","published-print":{"date-parts":[[1998,4]]}},"alternative-id":["S0021925818525485"],"URL":"https:\/\/doi.org\/10.1074\/jbc.273.14.8217","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1998,4]]}}}