{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:02:19Z","timestamp":1773658939557,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"22","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":7824,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1999,5]]},"DOI":"10.1074\/jbc.274.22.15466","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:01:01Z","timestamp":1027695661000},"page":"15466-15472","source":"Crossref","is-referenced-by-count":45,"title":["The p75NTR-induced Apoptotic Program Develops through a Ceramide-Caspase Pathway Negatively Regulated by Nitric Oxide"],"prefix":"10.1016","volume":"274","author":[{"given":"Jean-Philippe","family":"Li\u00e8vremont","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Sciorati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Morandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Paolucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Bunone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliano","family":"Della Valle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"Meldolesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Clementi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.274.22.15466_bib1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1126\/science.8235590","volume":"262","author":"Raff","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.274.22.15466_bib2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0301-0082(95)00041-0","volume":"48","author":"Henderson","year":"1996","journal-title":"Prog. Neurobiol. (Oxf.)"},{"key":"10.1074\/jbc.274.22.15466_bib3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00019052-199708000-00004","volume":"10","author":"Stefanis","year":"1997","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1074\/jbc.274.22.15466_bib4","first-page":"668","volume":"4","author":"Heumann","year":"1994","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.274.22.15466_bib5","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0166-2236(95)93922-K","volume":"18","author":"Chao","year":"1995","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.274.22.15466_bib6","first-page":"579","volume":"5","author":"Greene","year":"1995","journal-title":"Curr. Biol."},{"key":"10.1074\/jbc.274.22.15466_bib7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0092-8674(00)81874-7","volume":"88","author":"Nagata","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.274.22.15466_bib8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0092-8674(00)80430-4","volume":"91","author":"Salvesen","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.274.22.15466_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0166-2236(96)01049-1","volume":"20","author":"Bredesen","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1074\/jbc.274.22.15466_bib10","doi-asserted-by":"crossref","first-page":"6988","DOI":"10.1523\/JNEUROSCI.17-18-06988.1997","volume":"17","author":"Majdan","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.274.22.15466_bib11","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/sj.cdd.4400385","volume":"5","author":"Miller","year":"1998","journal-title":"Cell Death Differ."},{"key":"10.1074\/jbc.274.22.15466_bib12","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/383716a0","volume":"383","author":"Casaccia-Bonnefil","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.274.22.15466_bib13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/383166a0","volume":"383","author":"Frade","year":"1996","journal-title":"Nature"},{"key":"10.1074\/jbc.274.22.15466_bib14","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1083\/jcb.143.6.1691","volume":"143","author":"Aloyz","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.274.22.15466_bib15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0165-6147(97)90619-2","volume":"18","author":"Nicotera","year":"1997","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1074\/jbc.274.22.15466_bib16","doi-asserted-by":"crossref","first-page":"23211","DOI":"10.1074\/jbc.272.37.23211","volume":"272","author":"Sciorati","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.22.15466_bib17","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1084\/jem.187.3.415","volume":"187","author":"Hebestreit","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.274.22.15466_bib18","doi-asserted-by":"crossref","first-page":"24125","DOI":"10.1074\/jbc.272.39.24125","volume":"272","author":"Mannick","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.22.15466_bib19","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.185.4.601","volume":"4","author":"Dimmeler","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.274.22.15466_bib20","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/sj.onc.1200972","volume":"14","author":"Bunone","year":"1997","journal-title":"Oncogene"},{"key":"10.1074\/jbc.274.22.15466_bib21","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.4049\/jimmunol.154.8.3704","volume":"154","author":"Ferrarini","year":"1995","journal-title":"J. Immunol."},{"key":"10.1074\/jbc.274.22.15466_bib22","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1084\/jem.182.5.1545","volume":"182","author":"Martin","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1074\/jbc.274.22.15466_bib23","doi-asserted-by":"crossref","first-page":"29304","DOI":"10.1074\/jbc.271.46.29304","volume":"271","author":"Rooney","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.22.15466_bib24","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1073\/pnas.87.2.682","volume":"87","author":"Bredt","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.22.15466_bib25","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1523\/JNEUROSCI.16-18-05654.1996","volume":"16","author":"Srinivasan","year":"1996","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.274.22.15466_bib26","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1083\/jcb.137.5.1117","volume":"137","author":"Farschon","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.274.22.15466_bib27","doi-asserted-by":"crossref","first-page":"5916","DOI":"10.1074\/jbc.273.10.5916","volume":"273","author":"Schwandner","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.22.15466_bib28","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/0896-6273(94)90327-1","volume":"12","author":"Verdi","year":"1994","journal-title":"Neuron"},{"key":"10.1074\/jbc.274.22.15466_bib29","doi-asserted-by":"crossref","first-page":"23547","DOI":"10.1074\/jbc.272.38.23547","volume":"272","author":"MacPhee","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.22.15466_bib30","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.1523\/JNEUROSCI.17-16-06031.1997","volume":"17","author":"Maliartchouk","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.274.22.15466_bib31","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1523\/JNEUROSCI.18-04-01297.1998","volume":"18","author":"Ladiwala","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.274.22.15466_bib32","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/0092-8674(94)90275-5","volume":"78","author":"Wiegmann","year":"1994","journal-title":"Cell"},{"key":"10.1074\/jbc.274.22.15466_bib33","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1002\/j.1460-2075.1995.tb00274.x","volume":"14","author":"Cifone","year":"1995","journal-title":"EMBO J."},{"key":"10.1074\/jbc.274.22.15466_bib34","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1126\/science.8332899","volume":"261","author":"Rabizadeh","year":"1993","journal-title":"Science"},{"key":"10.1074\/jbc.274.22.15466_bib35","doi-asserted-by":"crossref","first-page":"6501","DOI":"10.1073\/pnas.91.14.6501","volume":"91","author":"Barrett","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.22.15466_bib36","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1126\/science.281.5383.1680","volume":"281","author":"Wang","year":"1998","journal-title":"Science"},{"key":"10.1074\/jbc.274.22.15466_bib37","doi-asserted-by":"crossref","first-page":"18117","DOI":"10.1074\/jbc.273.29.18117","volume":"273","author":"Hehner","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.22.15466_bib38","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1146\/annurev.pa.35.040195.001241","volume":"35","author":"Zhang","year":"1995","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1074\/jbc.274.22.15466_bib39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1615\/CritRevNeurobiol.v10.i3-4.20","volume":"10","author":"Yun","year":"1996","journal-title":"Crit. Rev. Neurobiol."},{"key":"10.1074\/jbc.274.22.15466_bib40","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1523\/JNEUROSCI.17-12-04633.1997","volume":"17","author":"Samdani","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.274.22.15466_bib41","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/364577a0","volume":"364","author":"Lipton","year":"1993","journal-title":"Nature"},{"key":"10.1074\/jbc.274.22.15466_bib42","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0304-3940(97)00780-5","volume":"236","author":"Tenneti","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1074\/jbc.274.22.15466_bib43","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1523\/JNEUROSCI.14-03-01746.1994","volume":"14","author":"Williams","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.274.22.15466_bib44","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1126\/science.7521541","volume":"265","author":"Wu","year":"1994","journal-title":"Science"},{"key":"10.1074\/jbc.274.22.15466_bib45","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0896-6273(94)90347-6","volume":"13","author":"Roskams","year":"1994","journal-title":"Neuron"},{"key":"10.1074\/jbc.274.22.15466_bib46","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/0092-8674(92)90286-L","volume":"69","author":"Lee","year":"1992","journal-title":"Cell"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819730464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819730464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.274.22.15466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T13:09:16Z","timestamp":1682168956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819730464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5]]},"references-count":46,"journal-issue":{"issue":"22","published-print":{"date-parts":[[1999,5]]}},"alternative-id":["S0021925819730464"],"URL":"https:\/\/doi.org\/10.1074\/jbc.274.22.15466","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1999,5]]}}}