{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:41:42Z","timestamp":1789915302902,"version":"4.0.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"33","license":[{"start":{"date-parts":[[1999,8,1]],"date-time":"1999-08-01T00:00:00Z","timestamp":933465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T00:00:00Z","timestamp":1601683200000},"content-version":"vor","delay-in-days":7734,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1999,8]]},"DOI":"10.1074\/jbc.274.33.23647","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:59:58Z","timestamp":1027695598000},"page":"23647-23658","source":"Crossref","is-referenced-by-count":50,"title":["Membrane Topology of Alzheimer's Disease-related Presenilin 1"],"prefix":"10.1016","volume":"274","author":[{"given":"Toshiki","family":"Nakai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kosaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Mihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Amaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Miura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.274.33.23647_bib1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.1074\/jbc.274.33.23647_bib2","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1126\/science.7638621","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.1074\/jbc.274.33.23647_bib3","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/376775a0","volume":"376","author":"Rogaev","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.274.33.23647_bib4","doi-asserted-by":"crossref","first-page":"12180","DOI":"10.1073\/pnas.92.26.12180","volume":"92","author":"Li","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.33.23647_bib5","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.274.33.23647_bib6","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/(SICI)1097-4547(19970915)49:6<719::AID-JNR6>3.0.CO;2-A","volume":"49","author":"Culvenor","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"10.1074\/jbc.274.33.23647_bib7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nm0296-224","volume":"2","author":"Kovacs","year":"1996","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.274.33.23647_bib8","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1523\/JNEUROSCI.17-06-01971.1997","volume":"17","author":"Lah","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1074\/jbc.274.33.23647_bib9","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1006\/bbrc.1996.1523","volume":"227","author":"Takashima","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.274.33.23647_bib10","doi-asserted-by":"crossref","first-page":"9926","DOI":"10.1073\/pnas.94.18.9926","volume":"94","author":"Dewji","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.33.23647_bib11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/377351a0","volume":"377","author":"Levitan","year":"1995","journal-title":"Nature"},{"key":"10.1074\/jbc.274.33.23647_bib12","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0092-8674(00)80244-5","volume":"89","author":"Shen","year":"1997","journal-title":"Cell"},{"key":"10.1074\/jbc.274.33.23647_bib13","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/387288a0","volume":"387","author":"Wong","year":"1997","journal-title":"Nature"},{"key":"10.1074\/jbc.274.33.23647_bib14","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0896-6273(00)80230-5","volume":"17","author":"Borchelt","year":"1996","journal-title":"Neuron"},{"key":"10.1074\/jbc.274.33.23647_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nm0197-67","volume":"3","author":"Citron","year":"1997","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.274.33.23647_bib16","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nm0896-864","volume":"2","author":"Scheuner","year":"1996","journal-title":"Nat. Med."},{"key":"10.1074\/jbc.274.33.23647_bib17","doi-asserted-by":"crossref","first-page":"7977","DOI":"10.1074\/jbc.272.12.7977","volume":"272","author":"Xia","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.33.23647_bib18","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/34910","volume":"391","author":"De Strooper","year":"1998","journal-title":"Nature"},{"key":"10.1074\/jbc.274.33.23647_bib19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00001756-199612200-00074","volume":"8","author":"Guo","year":"1996","journal-title":"Neuroreport"},{"key":"10.1074\/jbc.274.33.23647_bib20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1083\/jcb.139.2.485","volume":"139","author":"Janicki","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.274.33.23647_bib21","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1126\/science.271.5248.521","volume":"271","author":"Vito","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.274.33.23647_bib22","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1126\/science.274.5293.1710","volume":"274","author":"Wolozin","year":"1996","journal-title":"Science"},{"key":"10.1074\/jbc.274.33.23647_bib23","doi-asserted-by":"crossref","first-page":"14025","DOI":"10.1073\/pnas.94.25.14025","volume":"94","author":"Dewji","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.33.23647_bib24","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0896-6273(00)80232-9","volume":"17","author":"Doan","year":"1996","journal-title":"Neuron"},{"key":"10.1074\/jbc.274.33.23647_bib25","doi-asserted-by":"crossref","first-page":"12047","DOI":"10.1074\/jbc.272.18.12047","volume":"272","author":"Lehmann","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.33.23647_bib26","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0896-6273(00)80231-7","volume":"17","author":"Li","year":"1996","journal-title":"Neuron"},{"key":"10.1074\/jbc.274.33.23647_bib27","doi-asserted-by":"crossref","first-page":"7109","DOI":"10.1073\/pnas.95.12.7109","volume":"95","author":"Li","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.33.23647_bib28","doi-asserted-by":"crossref","first-page":"15925","DOI":"10.1016\/S0021-9258(17)36347-0","volume":"260","author":"Dalbey","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.33.23647_bib29","first-page":"921","volume":"2","author":"Yamamoto","year":"1997","journal-title":"Adv. Comp. Endocrinol."},{"key":"10.1074\/jbc.274.33.23647_bib30","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1074\/jbc.274.33.23647_bib31","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/oxfordjournals.jbchem.a133158","volume":"88","author":"Mori","year":"1980","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1074\/jbc.274.33.23647_bib32","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1083\/jcb.91.2.545","volume":"91","author":"Walter","year":"1981","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.274.33.23647_bib33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0092-8674(88)90009-8","volume":"55","author":"Wessels","year":"1988","journal-title":"Cell"},{"key":"10.1074\/jbc.274.33.23647_bib34","doi-asserted-by":"crossref","first-page":"8806","DOI":"10.1016\/S0021-9258(18)47486-8","volume":"262","author":"Moore","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.33.23647_bib35","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF00281625","volume":"239","author":"Johansson","year":"1993","journal-title":"Mol. Gen. Genet."},{"key":"10.1074\/jbc.274.33.23647_bib36","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0014-5793(96)00608-4","volume":"389","author":"Mercken","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.274.33.23647_bib37","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0896-6273(00)80291-3","volume":"17","author":"Thinakaran","year":"1996","journal-title":"Neuron"},{"key":"10.1074\/jbc.274.33.23647_bib38","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1006\/nbdi.1997.0129","volume":"3","author":"Podlisny","year":"1997","journal-title":"Neurobiol. Dis."},{"key":"10.1074\/jbc.274.33.23647_bib39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1083\/jcb.93.1.97","volume":"93","author":"Fujiki","year":"1982","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.274.33.23647_bib40","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1074\/jbc.272.6.3590","volume":"272","author":"De Strooper","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.33.23647_bib41","doi-asserted-by":"crossref","first-page":"5349","DOI":"10.1073\/pnas.94.10.5349","volume":"94","author":"Walter","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.33.23647_bib42","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1002\/j.1460-2075.1995.tb00030.x","volume":"14","author":"Dunlop","year":"1995","journal-title":"EMBO J."},{"key":"10.1074\/jbc.274.33.23647_bib43","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1242\/jcs.107.7.1817","volume":"107","author":"Finbow","year":"1994","journal-title":"J. Cell Sci."},{"key":"10.1074\/jbc.274.33.23647_bib44","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1126\/science.1970195","volume":"248","author":"Lopez","year":"1990","journal-title":"Science"},{"key":"10.1074\/jbc.274.33.23647_bib45","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/343669a0","volume":"343","author":"Yost","year":"1990","journal-title":"Nature"},{"key":"10.1074\/jbc.274.33.23647_bib46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0092-8674(00)81083-1","volume":"85","author":"Nishiyama","year":"1996","journal-title":"Cell"},{"key":"10.1074\/jbc.274.33.23647_bib47","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/0896-6273(95)90327-5","volume":"14","author":"MacKinnon","year":"1995","journal-title":"Neuron"},{"key":"10.1074\/jbc.274.33.23647_bib48","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/0896-6273(94)90419-7","volume":"13","author":"Hallmann","year":"1994","journal-title":"Neuron"},{"key":"10.1074\/jbc.274.33.23647_bib49","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0896-6273(95)90293-7","volume":"14","author":"Bennett","year":"1995","journal-title":"Neuron"},{"key":"10.1074\/jbc.274.33.23647_bib50","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1002\/bip.1968.360061006","volume":"6","author":"Venkatachalam","year":"1968","journal-title":"Biopolymers"},{"key":"10.1074\/jbc.274.33.23647_bib51","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0022-2836(82)90515-0","volume":"157","author":"Kyte","year":"1982","journal-title":"J. Mol. Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819653287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819653287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.274.33.23647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T06:14:24Z","timestamp":1641190464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819653287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,8]]},"references-count":51,"journal-issue":{"issue":"33","published-print":{"date-parts":[[1999,8]]}},"alternative-id":["S0021925819653287"],"URL":"https:\/\/doi.org\/10.1074\/jbc.274.33.23647","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1999,8]]}}}