{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T17:21:23Z","timestamp":1786296083496,"version":"build-2736575974"},"reference-count":61,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":7950,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[1999,1]]},"DOI":"10.1074\/jbc.274.4.2446","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:01:01Z","timestamp":1027695661000},"page":"2446-2455","source":"Crossref","is-referenced-by-count":230,"title":["Induction of Collagenase-3 (MMP-13) Expression in Human Skin Fibroblasts by Three-dimensional Collagen Is Mediated by p38 Mitogen-activated Protein Kinase"],"prefix":"10.1016","volume":"274","author":[{"given":"Laura","family":"Ravanti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyrki","family":"Heino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"L\u00f3pez-Ot\u0131\u0301n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veli-Matti","family":"K\u00e4h\u00e4ri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1074\/jbc.274.4.2446_bib1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/10454411930040020401","volume":"4","author":"Birkedal-Hansen","year":"1993","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"10.1074\/jbc.274.4.2446_bib2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1600-0625.1997.tb00164.x","volume":"6","author":"K\u00e4h\u00e4ri","year":"1997","journal-title":"Exp. Dermatol."},{"key":"10.1074\/jbc.274.4.2446_bib3","doi-asserted-by":"crossref","first-page":"28509","DOI":"10.1074\/jbc.271.45.28509","volume":"271","author":"Krane","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib4","doi-asserted-by":"crossref","first-page":"16766","DOI":"10.1016\/S0021-9258(19)89457-7","volume":"269","author":"Freije","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib5","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1074\/jbc.271.3.1544","volume":"271","author":"Kn\u00e4uper","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib6","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1172\/JCI118475","volume":"97","author":"Mitchell","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.274.4.2446_bib7","doi-asserted-by":"crossref","first-page":"7608","DOI":"10.1074\/jbc.272.12.7608","volume":"272","author":"Kn\u00e4uper","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/(SICI)1097-0177(199703)208:3<387::AID-AJA9>3.0.CO;2-E","volume":"208","author":"Johansson","year":"1997","journal-title":"Dev. Dyn."},{"key":"10.1074\/jbc.274.4.2446_bib9","first-page":"717","volume":"76","author":"St\u00e5hle-B\u00e4ckdahl","year":"1997","journal-title":"Lab. Invest."},{"key":"10.1074\/jbc.274.4.2446_bib10","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1172\/JCI118636","volume":"97","author":"Reboul","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.274.4.2446_bib11","first-page":"590","volume":"23","author":"Wernicke","year":"1996","journal-title":"J. Rheumatol."},{"key":"10.1074\/jbc.274.4.2446_bib12","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/art.1780400806","volume":"40","author":"Lindy","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1074\/jbc.274.4.2446_bib13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/1523-1747.ep12276722","volume":"109","author":"Vaalamo","year":"1997","journal-title":"J. Invest. Dermatol."},{"key":"10.1074\/jbc.274.4.2446_bib14","first-page":"1005","volume":"152","author":"Vaalamo","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.274.4.2446_bib15","first-page":"1489","volume":"152","author":"Uitto","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.274.4.2446_bib16","first-page":"273","volume":"149","author":"Heppner","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.274.4.2446_bib17","first-page":"4882","volume":"57","author":"Ur\u0131\u0301a","year":"1997","journal-title":"Cancer Res."},{"key":"10.1074\/jbc.274.4.2446_bib18","first-page":"499","volume":"151","author":"Johansson","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.274.4.2446_bib19","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/1523-1747.ep12319441","volume":"109","author":"Airola","year":"1997","journal-title":"J. Invest. Dermatol."},{"key":"10.1074\/jbc.274.4.2446_bib20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0002-9440(10)65549-6","volume":"153","author":"Ur\u0131\u0301a","year":"1998","journal-title":"Am. J. Pathol."},{"key":"10.1074\/jbc.274.4.2446_bib21","first-page":"243","volume":"8","author":"Johansson","year":"1997","journal-title":"Cell Growth Differ."},{"key":"10.1074\/jbc.274.4.2446_bib22","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0945-053X(98)90019-1","volume":"16","author":"Giambernardi","year":"1997","journal-title":"Matrix Biol."},{"key":"10.1074\/jbc.274.4.2446_bib23","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1172\/JCI116073","volume":"90","author":"Saarialho-Kere","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.274.4.2446_bib24","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1172\/JCI116906","volume":"92","author":"Saarialho-Kere","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1074\/jbc.274.4.2446_bib25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1365-2133.1996.tb03607.x","volume":"135","author":"Vaalamo","year":"1996","journal-title":"Br. J. Dermatol."},{"key":"10.1074\/jbc.274.4.2446_bib26","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1083\/jcb.109.2.863","volume":"109","author":"Akiyama","year":"1989","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.274.4.2446_bib27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/bbrc.1995.1490","volume":"209","author":"Riikonen","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1074\/jbc.274.4.2446_bib28","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1074\/jbc.274.4.2446_bib29","doi-asserted-by":"crossref","first-page":"6600","DOI":"10.1016\/S0021-9258(19)84605-7","volume":"261","author":"Goldberg","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib30","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.1016\/S0021-9258(18)68705-8","volume":"263","author":"Saus","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib31","doi-asserted-by":"crossref","first-page":"6579","DOI":"10.1016\/S0021-9258(18)68680-6","volume":"263","author":"Collier","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib32","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1432-1033.1996.0239u.x","volume":"239","author":"Lohi","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1074\/jbc.274.4.2446_bib33","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/nar\/16.1.349","volume":"16","author":"M\u00e4kel\u00e4","year":"1988","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.274.4.2446_bib34","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/nar\/13.5.1431","volume":"13","author":"Fort","year":"1985","journal-title":"Nucleic Acids Res."},{"key":"10.1074\/jbc.274.4.2446_bib35","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1074\/jbc.273.9.5137","volume":"273","author":"Reunanen","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib36","doi-asserted-by":"crossref","first-page":"13548","DOI":"10.1074\/jbc.270.22.13548","volume":"270","author":"Riikonen","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib37","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1083\/jcb.131.6.1903","volume":"131","author":"Langholz","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.274.4.2446_bib38","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1083\/jcb.137.6.1445","volume":"137","author":"Pilcher","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.274.4.2446_bib39","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/1523-1747.ep12364810","volume":"101","author":"Ivarsson","year":"1993","journal-title":"J. Invest. Dermatol."},{"key":"10.1074\/jbc.274.4.2446_bib40","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/jcp.1041570125","volume":"157","author":"Larjava","year":"1993","journal-title":"J. Cell. Physiol."},{"key":"10.1074\/jbc.274.4.2446_bib41","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1146\/annurev.cb.11.110195.003001","volume":"11","author":"Schwartz","year":"1995","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1074\/jbc.274.4.2446_bib42","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0955-0674(98)80144-0","volume":"10","author":"Howe","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.274.4.2446_bib43","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/excr.1994.1056","volume":"211","author":"Roeckel","year":"1994","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.274.4.2446_bib44","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/excr.1996.0295","volume":"228","author":"Broberg","year":"1996","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.274.4.2446_bib45","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0955-0674(97)80061-0","volume":"9","author":"Robinson","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1074\/jbc.274.4.2446_bib46","doi-asserted-by":"crossref","first-page":"7686","DOI":"10.1073\/pnas.92.17.7686","volume":"92","author":"Dudley","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1074\/jbc.274.4.2446_bib47","doi-asserted-by":"crossref","first-page":"27489","DOI":"10.1074\/jbc.270.46.27489","volume":"270","author":"Alessi","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib48","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0014-5793(95)00357-F","volume":"364","author":"Cuenda","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1074\/jbc.274.4.2446_bib49","doi-asserted-by":"crossref","first-page":"30864","DOI":"10.1074\/jbc.271.48.30864","volume":"271","author":"Kumar","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib50","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/369156a0","volume":"369","author":"Kyriakis","year":"1994","journal-title":"Nature"},{"key":"10.1074\/jbc.274.4.2446_bib51","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1083\/jcb.124.4.401","volume":"124","author":"Grinnel","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.274.4.2446_bib52","doi-asserted-by":"crossref","first-page":"26006","DOI":"10.1016\/S0021-9258(18)47151-7","volume":"269","author":"Kamata","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib53","doi-asserted-by":"crossref","first-page":"22811","DOI":"10.1016\/S0021-9258(17)31717-9","volume":"269","author":"Kern","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib54","doi-asserted-by":"crossref","first-page":"29309","DOI":"10.1074\/jbc.272.46.29309","volume":"272","author":"Takeuchi","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib55","doi-asserted-by":"crossref","first-page":"30022","DOI":"10.1016\/S0021-9258(18)43983-X","volume":"269","author":"Sudbeck","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib56","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.136.2.473","volume":"136","author":"Xu","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1074\/jbc.274.4.2446_bib57","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1006\/excr.1997.3640","volume":"235","author":"Langholz","year":"1997","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.274.4.2446_bib58","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1074\/jbc.273.6.3604","volume":"273","author":"Haas","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib59","doi-asserted-by":"crossref","first-page":"9769","DOI":"10.1074\/jbc.273.16.9769","volume":"273","author":"Ur\u0131\u0301a","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1074\/jbc.274.4.2446_bib60","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1006\/excr.1997.3676","volume":"235","author":"Atula","year":"1997","journal-title":"Exp. Cell Res."},{"key":"10.1074\/jbc.274.4.2446_bib61","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1242\/jcs.111.8.1127","volume":"111","author":"Messent","year":"1998","journal-title":"J. Cell Sci."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819881978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925819881978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1074\/jbc.274.4.2446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T03:03:37Z","timestamp":1641265417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925819881978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["S0021925819881978"],"URL":"https:\/\/doi.org\/10.1074\/jbc.274.4.2446","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[1999,1]]}}}